They say that there is no direct evidence that rosacea is primarily a vascular disorder. I've seen it in a few places referred to as 'Weak, Leaky capillaries'. Dan pointed out previously that Telangiectasia refers directly to permanently dilated vessels, not broken or leaky vessels, so the following quote from the article seems to make sense.
Quote
"The basic abnormality seems to be a microcirculatory disturbance of the function of the facial angular veins"
I guess if they have located a recurrent abnormality, then resolving this issue could prove beneficial.
I take an anit-histamine every day, and part of my diet restrictions include avoiding foods that are high in histamine, or would cause the body to release histamine. I am not sure if I read this correctly, but a quoted line of text says
Quote
"The response of the facial vessels to adrenaline, histamine and acetylcholine is normal, and the vessels do not seem abnormally fragile, so the main abnormality is probably in the dermis surrounding blood vessels rather than in vessel walls."
Which to my understanding suggested histamine was not an agonist to facial flushing.
And they then say this
Quote
"Among the mediators proposed to be involved in the erythematous response are substance P, histamine, serotonin, and prostaglandins but the trigger remains unknown."
Does this mean that although histamine is not directly related to facial flushing, that it is related to swelling/inflammation (erythematous response) of the surrounding skin?
And I see there is a new subtype, "Gram Negative Rosacea'. Is this any of your doing Dan?
Another couple of paragraphs that caught my attention were the reference to Demodex Folliculorum.
Quote
"As stated above, we do not think that Demodex folliculorum mites have a causal role in rosacea. However, massive infestations may aggravate the condition. A check for mites is best done with the skin-surface biopsy technique (place a drop of cyanoacrylate on a glass slide, cover with immersion oil, and examine with the 10 x or 20 x objective in the light microscope)"
"The mites are satisfactorily controlled with lindane (y-hexachlorocyclohexane), crotamiton, or benzyl benzoate once daily for two to five days."
The statement shows a satisfactory control of mites with the application of lindane, crotamiton or benzyl benzoate (toxic insecticides I am assuming) in five days. If a Rosacea patient has been checked and confirmed to be mite infested, this seems like a MUCH better treatment option (Of course recommended by a Derm or Doctor and applied with supervision) than the long and hard process Tamara has been going through.
Matt.
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