Rosacea News January 2012

1. IPL Burns from Perth Home Operator

An article in this Weekend’s West Australian highlighting the dangers of IPL Treatments from untrained operators. This article is a reminder of the dangers of IPL in the wrong hands. Other warnings are, sadly, easy to find. Finding the right practitioner to treat you with IPL is not an easy task. This is a real dilemma for rosacea sufferers as we …

2. Taro Readying for Generic Metrogel 1%

A recently posted clinical trial suggests that Taro Pharmaceuticals is readying to gain approval to market Generic Metrogel 1%. Currently Generic Metrogel is only available in 0.75% strength. Taro Pharmaceuticals in fact already markets a generic form of Metrogel – Metronidazole Gel USP, 0.75% When the patent covering Metrogel 0.75% expired, Galderma changed the formulation, increased the concentration of metronidazole to 1% …

3. Patents Expire for Liptor and Zyprexa, Oracea Small Fry

While us in the rosacea world might consider products that are expensive while they are covered by exclusive patents, we are small fry in the drug market at large.

Patents are due to shortly expire for Pfizer’s Liptor and Lilly’s Zyprexa. Lilly can expect a $3bn drop in revenue just from generic forms  of Zyprexa becoming available. Pfizer is thought to have earned around $7.8bn from …

4. Metrogel 1% Pump; for those who don’t like a Tube?

Galderma have announced that Metrogel 1% will now be available in a 55gm Pump. Galderma are citing the benefits of a better looking dispenser, minimizing waste, easier compliance with prescribing instructions and “facilitating product handling”. Galderma received FDA …

5. 2011, The Year in Review

Happy New Year to everyone who reads Rosacea Support ! As we start 2012 lets look briefly at what was popular in the last year. …

Rosacea News February 2012

1. Treating Neurogenic Rosacea with ETS

Now that the collection of symptoms called Neurogenic Rosacea has become more widely known, new discussions can take place as, for example how to best treat it.

This recently published abstract details a patient who suffered debilitating facial redness and burning. The patient was treated with the invasive and possibly irreversible procedure Endoscopic Thoracic Sympathectomy. The patient had a good response to ETS.

2. Cyclosporin better than Artificial Tears for Ocular Rosacea

Skin and Allergy News has an article today highlighting the recent positive research into the usage of Cyclosporin as a treatment for Ocular Rosacea.

Dr. Harper mentions that she likes to include Oracea as an oral treatment for the worst of her ocular rosacea patients, but …

3. Get ready for Tinted Finacea

A recently surfaced patent assigned to Intendis suggests that we might soon see a Tinted Finacea reach the market.

According to the patent application, a tinted formulation of Finacea had improved anti-inflammatory effects compared to regular Finacea – “Surprisingly, it was found that there was a further marked reduction in cytokine release in the cultures treated with azelaic acid and titanium dioxide-coated potassium aluminium silicate 3%”.

4. Doxycycline can deactivate Cathelicidins

A recently published abstract from the house of Gallo suggests a clue as to how doxycycline might work in treating rosacea. The suggestion from this research is that doxycycline has a newly discovered mechanism of action whereby it is able to prevent the activation of cathelicidin.

Cathelicidin has been in the rosacea news since around 2002, gaining publicity because of the discoveries like the fact …

5. Maruho Acquires Cutanea Life Sciences

News this week that the Japanese company Maruho is to acquire Pennsylvania based Cutanea Life Sciences. Cutanea Life Sciences is developing Omiganan as a treatment for rosacea.
Maruho Co., Ltd. Acquires Cutanea Life Sciences, Inc.

6. Massive Rosacea Study (CD5024) Recruiting Underway

A large study looking at a treatment for the papules and pustules of rosacea is looking to recruit participants right across the US and Canada.

A web site just for this study has been created at www.pprstudy.com (Papulo – Pustular – Rosacea Study). On the site you can use your ZIP code to see if there is a study location close to you.

Rosacea News March 2012

1. Uriage Thermal Water for a Red Face (2012 AAD San Diego)

I have to admit that I had never heard of Uriage Thermal Water before reading this poster abstract. Best I can tell, Uriage Thermal Water is a mineral water sourced from the French Alps.  It “possesses an exceptionally high content of mineral salts and trace elements in comparison with thermal waters used in dermatology (i.e. 11,000 mg/l). These mineral salts and trace elements have …

2. La Roche-Posay and L’Oreal Sensitive Skin Research

Thought that the following Poster Session from the recent 2012 AAD Annual Meeting in San Diego was encouraging because we really do want to see new products being developed specifically for people with sensitive skin. La Roche Posay is one of the skincare brands owned by L’Oreal. La Roche Posay may be known to rosacea sufferers through the actually little-known Rosaliac UV …

3. Sansrosa Phase II Results at 2012 AAD San Diego

Some Phase II Trial results for Sansrosa were presented at the recent 2012 AAD Annual Meeting in San Diego. Joseph F. Fowler, M.D., Clinical Professor of Dermatology at the University of Louisville was the principal study investigator. A summary of these results was mentioned in October 2011 via a press release covered here: Sansrosa not Susceptible to Tolerance or Rebound Whilst …

4. Sulphur Still a Classic Treatment for Rosacea (2012 AAD San Diego)

The following Poster Session from the 2012 AAD meeting in San Diego aimed to raise the profile of the use of sulphur as a treatment in rosacea. Did you …

5. Frank C. Powell at 2012 AAD San Diego

If you were able to attend the 2012 annual meeting of the AAD in San Diego you would have been able to attend the following discussion group on Rosacea.  The director of the session, Prof. Powell is known to rosacea sufferers because of his excellent book Rosacea Diagnosis and Management. Powell has been a consultant dermatologist at the Mater Private Hospital in Dublin, …

6. Zinc Sulfate Doesn’t Work for Rosacea

Despite a 2006 study in a prestigious journal that showed some modest benefit from taking 100mg a day of Zinc Sufate, a more recent study with a …

7. Mysterious L’Oreal Lotion Good for Redness (2012 AAD San Diego)

At the recent AAD 2012 Annual Meeting in San Diego, a poster session sponsored by L’Oreal looked quite interesting. The session detailed some research on an un-named facial lotion. The research claimed a statistically significant improvement in redness after 4 weeks of use. No searching could find a product from L’Oreal that contained the following ingredients; palmitoyl tripeptide-8 …

8. Foamix Minocycline Foam works for Bacterial Infections

A recent press release teases rosacea sufferers that a topical foaming form of minocycline might become a new treatment. The trial results promoted in the press release are for a condition called Impetigo, …

9. Sansrosa Completes Phase III Trials

A short press release today from Galderma to say that the 2 Phase III trials for Sansrosa have completed successfully. These latest large scale trials were able to confirm the positive findings resulting from the Phase II trials. This must be a great relief to Galderma who had to return to Phase II trials after previously commencing Phase III trials. …

10. What about Acne in Children?

The following video from the American Acne & Rosacea Society will be interesting to those who are looking for more information about how to treat acne in children. Children require special attention when presenting with acne as some of the adult treatments may be unsuitable for children. The guidelines offer advice for adolescent acne, preadolescent acne, infantile and neonatal acne. …

11. Ziana Almost Works for Rosacea

In January 2009 we learnt that Medicis was interested in trialing Ziana as a treatment for rosacea. Medicis may be known to rosacea sufferers because they also make Plexion and Solodyn. Sadly the rigorous nature …

12. Avermectin Milbemycin Eyewash for Ocular Rosacea

This recently published patent is interesting for a couple of reasons. Firstly there is renewed interest in Ivermectin because of Galderma’s large trial of Topical Ivermectin 1% Cream (CD5024) for facial rosacea. Secondly there are few official treatments for ocular rosacea, so a provable treatment such as outlined in this patent could show promise. A word of caution is needed here of course. …

13. Azeloglicina (Azelaic Acid + Glycine) for the Redness of Rosacea

A newly published article introduces us to a new formulation of Azelaic Acid known as Azeloglicina. Azeloglicina (chemical name  Potassium Azeloyl Diglycinate) is described as a “condensation product between one mole of Azelaic Acid and two moles of Glycine” and is touted as an improvement over the individual properties of both. A company called Singerga holds the patent on Azeloglicina. …

Rosacea News April 2012

1. Demodex Bacteria Inhibits Corneal Wound Recovery

This just published abstract takes the demodex bacteria based irritation line of research a step further. Researchers in Ireland were able to show that demodex bacteria Bacillus oleronius proteins induced an “aberrant wound healing response” in  the cells irritated by scratch in a cornea. The aberration appeared as an elevated immune response and an chagnes in cells’ inability to move like normally …

2. Cetaphil DermaControl Oil Control Foam Wash and Moisturizer for Oily Skin

Cetaphil has launched 2 new products that are targeted at oily or acne-prone skin. The products are called, take a breath; Cetaphil DermaControl Oil Control Moisturiser SPF 30 and Cetaphil DermaControl Oil Control Foam Wash. The Oil Control Moisturizer is promoted as a lightweight 3-in-1 moisturizer for acne-prone skin. It is said to provide broad spectrum sun protection, control shine without over-drying. The SPF …

3. `My Naked Secret’ looking for Rosacea Sufferers

Live in the UK? Interesting in being a part in the My Naked Secret 2 series? The producers of this Channel 4 programme, who are based in London are looking …

4. Miranda from Sex and The City tells of her Rosacea

In a series of 6 videos, Cynthia Nixon who played Miranda in Sex and The City, talks about her battle with rosacea. The professionally produced videos point viewers to the …

5. Allergan Trialing Oxymetazoline for Facial Redness

A just-posted trial notification shows very early clinical trials by Allergan, for their product they have named AGN-199201. The double blind trial will compare 3 different formulations of AGN-199201 with with the vehicle. The decrease in redness …

6. Oracea Sales “Excellent”, Gaining Market Share

How much does Galderma earn each year from Oracea sales ? Well the actual amount is not published, but in September 2011 court proceedings we learnt that Mylan Pharmaceuticals projected sales of $260m in 2011 for Oracea. The parent company of Galderma, L’Oreal does not publish Oracea sales figures, so this press release is as close as you can find to something that …

7. “Medical Crowdsourcing” via CureTogether – the new cheap data collection method

A recent article in the Dermatology Online Journal introduced me to a new online support group site. Apparently curetogether.com is a major medical crowdsourcing site. What is crowdsourcing? Well crowdsourcing is a new buzzword which basically means to get your information from the “crowd” or as many people as you can. Online this term generally means something like “just asking everyone …

8. Oracea is Not an Antibiotic, Apparently

This claim from the Oracea web site caught my eye. Oracea is NOT an antibiotic. A bit of poetic marketing license perhaps?

Oracea is a 40mg dose of the antibiotic doxycycline, which is a member of the tetracycline family. 30mg of the dose of doxycycline is immediate release, and 10 mg is locked inside a coating that …

9. Theory: Ivermectin is Metrogel’s Cousin, Help Needed

OK, bear with me. I don’t often just waffle here as a Rosacea News item. Maybe I should. Anyway this post is just me exploring an idea. From my high school organic chemistry it seems to me that Ivermectin and Metrondizole are in fact chemically akin to cousins. I started to think about this because of the huge investment being undertaken by …

10. More Proof that CD5024 is Ivermectin

The mysterious CD5024 1% Cream for which Galderma is conducting a large Phase III trial, has further been confirmed as the anti-parasitic Ivermectin.

This latest confirmation comes from the World Heath Organisation’s International Clinical Trials Registry Platform Search Portal. The search for CD5024 reveals trials that have completed in the Czech Republic, Germany and Hungary. The register was created in 2006, the same year as when …

11. It would be hard to invent a more embarrassing disease than Rosacea

Thought this was a great line from a recent NRS Blog Posting: It would be hard to invent a more embarrassing disease than rosacea.  Nice. I’m sure many many rosacea sufferers would agree.

Cure and Banish Rosacea with junk ebooks

If you ever wanted to read Banish Rosacea by Robert Campbell then you don’t have to hand over any money just go to this link Rosacea Cure eBooks: All Just SPAM?. By the way, you won’t be surprised to learn that this spammy ebook wasn’t actually written by someone called Robert Campbell, it is just a made up name.

Also, there, you will find reviews of

• Rosacea, The Cure is in your kitchen by Ron Tramontano

• Cure Your Rosacea

• Autoimmune The Cause and Cure (Nature Had it First)

• Rosacea No More

• Rosacea Free Forever by Laura Taylor.

and a link to actually the book you should be buying.