Acne Rosacea: [rosacea] Experimental Topical Forskolin

Tuesday, November 28, 2006

[rosacea] Experimental Topical Forskolin

I'm really interested in this topical forsklin. I'm almost ready to
volunteer myself as a guinea pig to test it. lol...Its a cyclic AMP
agonist (Camp). It prevents UV skin damage...I'm just wondering if any
studies were done to show that roscea causes "UV type skin damage".
Suppos this stuff, according to these researchers will give you a tan
without sunlight. They just claim that its such a new discovery they
don't know what else it will do on the skin. However, my second biopsy
did come up with a pre cancerous type of skin damage...I wonder if
that was due to the roscea???? because it was on a place I normally
don't tan on. Anyways, I'm soooo tempted to try this out I have the
forsklin pills here. Maybe I'll wait just a little bit longer and see
if they get some results out. But the theory just seems to good on so
many different levels. If you make yourself become dark sinned maybe
you protect yourself from the reperfusion injury...how many rosceans
do you know that are dark pigmented?

Topical drug rescue strategy and skin protection based on the role
of Mc1r in UV-induced tanning.

* D'Orazio JA,
* Nobuhisa T,
* Cui R,
* Arya M,
* Spry M,
* Wakamatsu K,
* Igras V,
* Kunisada T,
* Granter SR,
* Nishimura EK,
* Ito S,
* Fisher DE.

Melanoma Program, Dana-Farber Cancer Institute & Children's
Hospital, 44 Binney Street, Boston, Massachusetts 02115, USA.

Ultraviolet-light (UV)-induced tanning is defective in numerous
'fair-skinned' individuals, many of whom contain functional disruption
of the melanocortin 1 receptor (MC1R). Although this suggested a
critical role for the MC1R ligand melanocyte stimulating hormone (MSH)
in this response, a genetically controlled system has been lacking in
which to determine the precise role of MSH-MC1R. Here we show that
ultraviolet light potently induces expression of MSH in keratinocytes,
but fails to stimulate pigmentation in the absence of functional MC1R
in red/blonde-haired Mc1r(e/e) mice. However, pigmentation could be
rescued by topical application of the cyclic AMP agonist forskolin,
without the need for ultraviolet light, demonstrating that the
pigmentation machinery is available despite the absence of functional
MC1R. This chemically induced pigmentation was protective against
ultraviolet-light-induced cutaneous DNA damage and tumorigenesis when
tested in the cancer-prone,
xeroderma-pigmentosum-complementation-group-C-deficient genetic
background. These data emphasize the essential role of intercellular
MSH signalling in the tanning response, and suggest a clinical
strategy for topical small-molecule manipulation of pigmentation.

PMID: 16988713 [PubMed - indexed for MED