Tuesday, November 28, 2006

[rosacea] Re: RE:: Experimental Topical Forskolin

Interesting, the other thing about forskolin is that, by mixing it
with another substance, it has been used to successfully create
schwann cells that continued to proliferate. This was done in skin
precursor cells:
http://www.medicalnewstoday.com/medicalnews.php?newsid=45177

also(if I recall correctly), when forskolin was mixed with a substance
from cranberries it regenerated the eyesight in lab mice.

This have been useful discoveries, another article the other day are
seeing it may be a breakthru to use on cancer as well. We have seen so
many medical breakthrus in the last year its amazing.

so, it may have another action of repairing skin cells (vis-a-vis the
small fiber nerves which modulate the capillaries) beyond increasing
melatonin. So I will keep my eyes out for any developments...if I
don't give into the temptation to get myself a tan!!! lol
Jon
--- In rosacea-support@yahoogroups.com, Matthew I <mtthw_i@...> wrote:
>
> It¢s definitely interesting, I¢ve been waiting for news on the
melanotan as well. It would be great for people here in Australia.
Unfortunately we have the highest skin cancer rate in the world here,
with over 380,000 people diagnosed every year.
>
> It¢s every young girls dream to be brown and tanned for the summer.
It is an image preconception that is starting to be seen in a lot of
guys my age as well. From around 12-18 I rarely used sunscreen, even
after I had a mole removed (a suspicious one). I thought I was
invincible and never thought anything of it. There needs to be more
Shocking Graphic evidence about what can happen. There is a good add
on Aus TV at the moment showing the removal of an extremely large
melanoma. If an alternative was provided to produce a nice brown tan
without UV exposure then it would be warmly welcomed in Australia.
>
> With Regards to Rosacea though, would it provide more than just a
cover? Less visible capillaries surrounded by the background of a
darker colour?
>
> I think there would still be problems from a lot of flush triggers
i.e. Food, Stress, Exercise, Heat. And with heat, although you would
have a stronger pigment which would help prevent damage to the
underlying cells, the absorbed heat could still possibly provoke a flush.
>
> You¢re definitely right about predisposed genetic factors resulting
in a higher occurrence of Rosacea. Individuals with fair skin,
particularly those of Scottish, Irish or Celtic descent statistically
have the highest incidence rate.
>
> However, I am fairly olive skinned, I¢m not as brown as I use to be
(being crammed in the office from 9-5 now) but put me in the sun for a
solid week and I¢ll go a dark shade of chocolate brown. I think Rikki
said he had olive skin. And there is a couple of posters from India on
here (excuse my bad memory not recalling your names) that I would
assume to be heavily pigmented. Maybe there is some other genetic
factor common among fair skinned people that makes them more
susceptible to Rosacea?. I¢m just speculating here though.
>
> Thanks for the Info Jon, Keep us all posted if you find out anything
else on Pigment enhancers without UV exposure. Australia has its ears
open!
>
> Matt.
>
----------------------------------------------------------
>
> I'm really interested in this topical forsklin. I'm almost ready to
> volunteer myself as a guinea pig to test it. lol...Its a cyclic AMP
> agonist (Camp). It prevents UV skin damage...I'm just wondering if any
> studies were done to show that roscea causes "UV type skin damage".
> Suppos this stuff, according to these researchers will give you a tan
> without sunlight. They just claim that its such a new discovery they
> don't know what else it will do on the skin. However, my second biopsy
> did come up with a pre cancerous type of skin damage...I wonder if
> that was due to the roscea???? because it was on a place I normally
> don't tan on. Anyways, I'm soooo tempted to try this out I have the
> forsklin pills here. Maybe I'll wait just a little bit longer and see
> if they get some results out. But the theory just seems to good on so
> many different levels. If you make yourself become dark sinned maybe
> you protect yourself from the reperfusion injury...how many rosceans
> do you know that are dark pigmented?
>
> Topical drug rescue strategy and skin protection based on the role
> of Mc1r in UV-induced tanning.
>
> * D'Orazio JA,
> * Nobuhisa T,
> * Cui R,
> * Arya M,
> * Spry M,
> * Wakamatsu K,
> * Igras V,
> * Kunisada T,
> * Granter SR,
> * Nishimura EK,
> * Ito S,
> * Fisher DE.
>
> Melanoma Program, Dana-Farber Cancer Institute & Children's
> Hospital, 44 Binney Street, Boston, Massachusetts 02115, USA.
>
> Ultraviolet- light (UV)-induced tanning is defective in numerous
> 'fair-skinned' individuals, many of whom contain functional disruption
> of the melanocortin 1 receptor (MC1R). Although this suggested a
> critical role for the MC1R ligand melanocyte stimulating hormone (MSH)
> in this response, a genetically controlled system has been lacking in
> which to determine the precise role of MSH-MC1R. Here we show that
> ultraviolet light potently induces expression of MSH in keratinocytes,
> but fails to stimulate pigmentation in the absence of functional MC1R
> in red/blonde-haired Mc1r(e/e) mice. However, pigmentation could be
> rescued by topical application of the cyclic AMP agonist forskolin,
> without the need for ultraviolet light, demonstrating that the
> pigmentation machinery is available despite the absence of functional
> MC1R. This chemically induced pigmentation was protective against
> ultraviolet- light-induced cutaneous DNA damage and tumorigenesis when
> tested in the cancer-prone,
> xeroderma-pigmentos um-complementati on-group- C-deficient genetic
> background. These data emphasize the essential role of intercellular
> MSH signalling in the tanning response, and suggest a clinical
> strategy for topical small-molecule manipulation of pigmentation.
>
> PMID: 16988713 [PubMed - indexed for MED
>
> Send instant messages to your online friends
http://au.messenger.yahoo.com
>
> [Non-text portions of this message have been removed]
>

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