Acne Rosacea: [rosacea] Grape seed extract/ antioxidant prooxidant effects

I ran into problems when I was taking about 20 different blood
thinners, french pine etc...this abstract doesn't tell us how much is
safe...right now I'm doing "stacking" trying to get as many
antioxidants as possible. but it's something to think about:

Grape seed proanthocyanidins induce pro-oxidant toxicity in
cardiomyocytes.

* Shao ZH,
* Vanden Hoek TL,
* Xie J,
* Wojcik K,
* Chan KC,
* Li CQ,
* Hamann K,
* Qin Y,
* Schumacker PT,
* Becker LB,
* Yuan CS.

Tang Center for Herbal Medicine Research, Emergency Resuscitation
Research Center, and Department of Medicine, Pritzker School of
Medicine, University of Chicago, Chicago, IL, USA.

Grape seed proanthocyanidin extract (GSPE), a polyphenolic
compound with antioxidant properties, may protect against cardiac
ischemia and reperfusion injury. However, its potential toxicity at
higher doses is unknown. The authors tested the effects of GSPE on
reactive oxygen species (ROS) generation, cell survival, lactate
dehydrogenase (LDH) release, and caspase- 3 activity using chick
cardiomyocytes incubated with GSPE at 5, 10, 50, 100, or 500
micrograms/mL in medium for 8 h. Exposure to increasing concentrations
of GSPE (100 or 500 micrograms/mL) resulted in an increase in ROS
generation and cell death as measured by propidium iodide uptake and
LDH release. Caspase-3 activity was significantly increased fourfold
in cells exposed to GSPE 500 micrograms/ mL compared to controls; this
was abolished by the selective caspase-3 inhibitor
Ac-Asp-Gln-Thr-Asp-H (50 microM), which also significantly reduced the
cell death resulting from GSPE (500 micrograms/mL). The antioxidant
N-acetylcysteine (NAC, 100 microM) reduced cell death induced by GSPE
(500 micrograms/mL) but failed to attenuate caspase-3 activation.
Collectively, the authors conclude that higher doses of GSPE could
cause apoptotic cell injury via effector caspase-3 activation and
subsequent induction of ROS generation. Consumers may take higher
doses of dietary supplements in the belief that natural herbs have no
major side effects. This study demonstrates that dosages of GSPE
should be optimized to avoid potential harmful pro-oxidant effects.

PMID: 14734830 [PubMed - indexed for MEDLINE]

--- In rosacea-support@yahoogroups.com, <kemx@...> wrote:
>
> and man....those grapeseed extracts give me some annoying
gas......not sbd's, but freight train going thru town type.hahaha
> i'm taking them before bed now so i don't have to honk the horn at
work all night.....hahhahahaha
> emily
> ----- Original Message -----
> From: Ricky Butler
> To: rosacea-support@yahoogroups.com
> Sent: Tuesday, November 28, 2006 10:18 AM
> Subject: Re: [rosacea] supplements
>
>
> I have noticed we all seem to take alot of supplements!
> its a good thing, but I have noticed as some of you probably
have too
> doesn't it get kinda costly?? haha
> I know it does for me! but I keep popping 'em!
>
> Ricky
>
> steve95301 <phaedrus128@...> wrote:
> Here's my supplement schedule, which I feel has worked well for me:
>
> Morning:
> --------
>
> -Multivitamin
> -B-complex vitamin
> -1000mg Fish oil
> -1000mg Vit. C
> -400 I.U. Vit. E
> -(3x)175mg Milk Thistle
> -200mg Alpha-lipoic acid
> -25mg Zinc gluconate
>
> Afternoon:
> ----------
>
> -(2x)1000mg Fish oil
> -(2x)200mg Alpha-lipoic acid
> -500mg Vit. C
> -(2x)175mg Milk Thistle
>
> Evening:
> --------
>
> -3mg Melatonin
>
> As-needed:
> ----------
>
> -Ginger root
> -Valerian root (anxiety)
> -Kava (anxiety)
> -Kratom (anxiety)
>
> Thinking of adding:
> -------------------
>
> -Turmeric
> -Oregano oil (topical + oral)
> -Pycnogenol/grape seed
> -Horse chestnut
>
> Tried and didn't like:
> ----------------------
>
> -DHEA
>
> Hope that gives you some ideas...
>
> -Steve
>
> --- In rosacea-support@yahoogroups.com, Ricky Butler
> wrote:
> >
> > I take a multi vitamin and a lysine (im prone to cold sores) and 400
> I.U. mixed tocopherol
> > vitamin E capsule along with 500 mg Ester-C every day and a combo
> pill of green tea/grapeseed/red wine capsule along with another lysine
> pill and alpha lipoic acid in the evening. I do it mainly for the
> antioxidant protection, im not sure if it prevents breakouts where im
> prone to them, but I do feel it helps my skins texture, helping to
> fend off free radical damage and all. the niacin in the multi doesn't
> bother me at all either.
> >
> > Ricky
> >
> > Kemx wrote:
> > i missed the zinc sulphate thread.
> > i take lysine, grapeseed extract,milk thistle, vit D3, alpha liopic,
> and recently added glutamine.--the niacin in my multi doesn't bother
> me. [i also take bilberry for my eyes, flax seed in a capsule,
> magnesium, 200mg. vit E, and potassium sometimes since my diet is so
> peculiar due to the rosacea and IBS].
> > i can't remember where i read about these hahaha......but my skin is
> clearing from a bad flare [which was probably caused by something that
> i'm not doing now...LOL].
> > but these sups are also good for my body too.
> > emily
> >
> > star52star52 wrote:
> > I have been trying to read the old posts, and feel a bit
overwhelmed!
> > I am going to buy some supplements to try to help-I have
flushing and
> > broken capillaries, and am surprised that some, such as evening
> > primrose oil, that I thought would be helpful seem to cause
problems
> > for people.
> >
> > What supplements should I try? I am considering grape seed extract,
> > salmon oil, pycnogenol, zinc sulphate-after reading that study
where
> > it seemed to really help heal rosacea recently, vitamin c, and
> > digestive enzymes. Do probiotics help? And I will avoid regular
> > multivitamins due to the niacin.
> >
> > Thanks!
> >
> >
> >
> > --
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> >
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> >
> >
> >
> >
> >
> >
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> >
> >
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> >
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> >
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>
>
> --
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>
> Yahoo! Groups Links
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> New ! Rosacea Support Resource Pages: http://rosacea-research.org/wiki
>
> Yahoo! Groups Links
>
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