It¢s every young girls dream to be brown and tanned for the summer. It is an image preconception that is starting to be seen in a lot of guys my age as well. From around 12-18 I rarely used sunscreen, even after I had a mole removed (a suspicious one). I thought I was invincible and never thought anything of it. There needs to be more Shocking Graphic evidence about what can happen. There is a good add on Aus TV at the moment showing the removal of an extremely large melanoma. If an alternative was provided to produce a nice brown tan without UV exposure then it would be warmly welcomed in Australia.
With Regards to Rosacea though, would it provide more than just a cover? Less visible capillaries surrounded by the background of a darker colour?
I think there would still be problems from a lot of flush triggers i.e. Food, Stress, Exercise, Heat. And with heat, although you would have a stronger pigment which would help prevent damage to the underlying cells, the absorbed heat could still possibly provoke a flush.
You¢re definitely right about predisposed genetic factors resulting in a higher occurrence of Rosacea. Individuals with fair skin, particularly those of Scottish, Irish or Celtic descent statistically have the highest incidence rate.
However, I am fairly olive skinned, I¢m not as brown as I use to be (being crammed in the office from 9-5 now) but put me in the sun for a solid week and I¢ll go a dark shade of chocolate brown. I think Rikki said he had olive skin. And there is a couple of posters from India on here (excuse my bad memory not recalling your names) that I would assume to be heavily pigmented. Maybe there is some other genetic factor common among fair skinned people that makes them more susceptible to Rosacea?. I¢m just speculating here though.
Thanks for the Info Jon, Keep us all posted if you find out anything else on Pigment enhancers without UV exposure. Australia has its ears open!
Matt.
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I'm really interested in this topical forsklin. I'm almost ready to
volunteer myself as a guinea pig to test it. lol...Its a cyclic AMP
agonist (Camp). It prevents UV skin damage...I'm just wondering if any
studies were done to show that roscea causes "UV type skin damage".
Suppos this stuff, according to these researchers will give you a tan
without sunlight. They just claim that its such a new discovery they
don't know what else it will do on the skin. However, my second biopsy
did come up with a pre cancerous type of skin damage...I wonder if
that was due to the roscea???? because it was on a place I normally
don't tan on. Anyways, I'm soooo tempted to try this out I have the
forsklin pills here. Maybe I'll wait just a little bit longer and see
if they get some results out. But the theory just seems to good on so
many different levels. If you make yourself become dark sinned maybe
you protect yourself from the reperfusion injury...how many rosceans
do you know that are dark pigmented?
Topical drug rescue strategy and skin protection based on the role
of Mc1r in UV-induced tanning.
* D'Orazio JA,
* Nobuhisa T,
* Cui R,
* Arya M,
* Spry M,
* Wakamatsu K,
* Igras V,
* Kunisada T,
* Granter SR,
* Nishimura EK,
* Ito S,
* Fisher DE.
Melanoma Program, Dana-Farber Cancer Institute & Children's
Hospital, 44 Binney Street, Boston, Massachusetts 02115, USA.
Ultraviolet- light (UV)-induced tanning is defective in numerous
'fair-skinned' individuals, many of whom contain functional disruption
of the melanocortin 1 receptor (MC1R). Although this suggested a
critical role for the MC1R ligand melanocyte stimulating hormone (MSH)
in this response, a genetically controlled system has been lacking in
which to determine the precise role of MSH-MC1R. Here we show that
ultraviolet light potently induces expression of MSH in keratinocytes,
but fails to stimulate pigmentation in the absence of functional MC1R
in red/blonde-haired Mc1r(e/e) mice. However, pigmentation could be
rescued by topical application of the cyclic AMP agonist forskolin,
without the need for ultraviolet light, demonstrating that the
pigmentation machinery is available despite the absence of functional
MC1R. This chemically induced pigmentation was protective against
ultraviolet- light-induced cutaneous DNA damage and tumorigenesis when
tested in the cancer-prone,
xeroderma-pigmentos um-complementati on-group- C-deficient genetic
background. These data emphasize the essential role of intercellular
MSH signalling in the tanning response, and suggest a clinical
strategy for topical small-molecule manipulation of pigmentation.
PMID: 16988713 [PubMed - indexed for MED
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