Hi Matt,
You're absolutely welcome. And you're right in that we do owe Dr.
Goldberg a big thanks for taking the time to answer some of our
questions to the best of his ability. I personally was very happy he
took the time to answer our questions as you'd be surprised how few
researchers and doctors are willing to do so. And of course I always
want to know more, but still, his answers reconfirmed some of my own
opinions on LLLT.
As for some of your questions though, I've found in my admittedly
limited interactions with medical researchers and doctors that they
are a very cautious group. They rarely seem to speculate, and they
nearly always use terms like "evidence seems to suggest" when
answering questions about mechanisms of action, etc.
I certainly cannot put words in any of these researcher's and doctor's
mouths, but I personally use terms like this when answering questions
about studies I've read, etc as I'd absolutely hate to give a
definitive answer to someone and then find another study later on that
suggests yet some other answer. This seems to particularly possible
when the science or technology is in its early stages of use and research.
To answer some of your questions though, based on my own readings of
the studies in pubmed related to LLLT devices, studies do seem to
suggest that, particularly red/near infrared LLLT devices are
antiinflammatory and antioxidant in nature, affecting TNF-a levels and
thus other cytokines and enzymes that are involved in inflammation as
well as superoxide dismutase levels which is key in clearing the
reactive oxygen species (ROS) that are responsible for cleaning up the
oxidants products of inflammation. See the RSRP for more info on this:
http://rosacea-
As for the quality of light output, the following study also on the
RSRP page above mentions that reduction of TNF-a is LLLT dose
dependent, and a 650-nm Ga-Al-As laser "LLLT dose of 0.11 Joules
administered with a power density of 31.3 mW/cm(2) in 42 sec
significantly reduced TNFalpha level to 50.2 (95% CI, 49.4-51.0), p <
0.01 units/mL versus control.":
http://www.ncbi.
How this compares to the home units, I unfortunately don't know.
Hopefully additional studies will shed more light on these questions
in the future...
I hope this helps some. Hang in there...
Dan
--- In rosacea-support@
>
> Hi Dan,
>
> Thanks for getting these questions off Dr Goldberg and a
big thanks to Dr Goldberg for answering them.
>
> I understand he would be an extremely busy man, However I feel like
he did not answer the questions thoroughly. He didn't provide any
evidence besides what he had seen. He only used statements such as
"appears to be" and "seems to suggest" which I don't think is the
proof that the Rosacean community needs.
>
> Once again, I understand he would be an extremely busy man, and I am
very grateful that he has already taken the time to answer these
questions, but is there any chance that he can explain the WHY behind
all the claims?
>
> For example, WHY did the Yellow LED treatment shrink the blood
vessels and what exactly did it do to them that caused a reduction in
visible size? Can you show us the studies? How many people was this
conducted on? By what factor were they made smaller?
>
> He answered a little more thoroughly to the question about RED /
N.I.R LED's when he said "Red and near-infrared LED have a major
impact on many cells that cause inflammation"
> But what is this major impact on many cells?
>
> Goldberg says "Home units generally are not powerful enough to lead
to same results as medical quality units"
>
> Can he elaborate on this? Regardless of the power source, The lighy
output of an LED will approach a limit. If you analyse the Light
Output Vs Drive current curve, the light output will flatten and
approach a maximum regardless of the drive current.
>
> Is this a scheme to make it seem essential that we go to a clinic
for treatments?
> Or is there some special high light output LED that is not available
for purchase by the general public? Can he supply his treatment levels
in Joules per square cm?
>
> I don't mean to sound unnappreciateive here. I am very thankful that
he answered some of our questions. But can he please provide the
evidence we need?
>
>
> Were you satisfied with his answers Dan?
>
> Matt.
>
>
>
------------
> Hi All,
>
> Dr David J. Goldberg, MD, director of Skin Laser & Surgery Specialists
> of New York and New Jersey and a clinical professor of dermatology and
> director of laser research at Mount Sinai School of Medicine in New
> York, has kindly answered a few questions for us on his Dermatology
> Times article, "Combining light-based treatments, topicals for
> rosacea". A compilation of these questions and answers has been
> added to Experts' Comments section of the Rosacea Support Resource
Pages:
>
> http://rosacea- research- foundation. org/wiki/ index.php/
Combining_ Light-Based_ Treatments_ and_Topicals_ for_Rosacea:
_Dr._David_ J._Goldberg% 2C_MD
>
> We'd like to thank Dr. Goldberg again for taking the time to help
> answer some of our questions.
>
> The full Rosacea Support Resource Page list can also be browsed from
> the following link (or by clicking on the link at the top right of the
> Rosacea Support home page):
>
> http://rosacea- research. org/wiki/ index.php/ Main_Page
>
> Hopefully this new page will provide information that you will find
> helpful. Please be sure to discuss the information contained within
> the Resource Pages with a qualified physician in order to determine
> the best form of treatment for you.
>
> And again, please feel free to send any feedback on the Resource
> Pages, including suggestions for modifications, additions, etc to
> wiki-feedback@ rosacea-research .org
>
> Dan
>
> Send instant messages to your online friends
http://au.messenger
>
> [Non-text portions of this message have been removed]
>
Please read the list highlights and FAQ: http://rosacea.ii.net
New ! Rosacea Support Resource Pages: http://rosacea-research.org/wiki
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