Rosacea News July 2012

Metronidazole Gel 2% Good for Acne

Acne seems to have a lot of available treatments. Certainly compared to rosacea, acne has a bigger array of possible treatments that have been proven to be viable treatments. One of the interesting things about rosacea is that even though it can look like acne for some, generally it cannot be treated by otherwise helpful acne treatments. Rosacea sufferers with sensitive skin may well …

Just Diagnosed: JAMA Rosacea Patient Page

The Journal of the American Medical Association have released a free Rosacea Patient Page in their June 2012 edition. The JAMA have made this page available for free. This may prove useful for those who are wondering if they have rosacea and those looking for a confirmation of their symptoms. The illustration shows the full gamut of rosacea symptoms: dry, red, irritated eyes, …

Ocular Rosacea Diagnostic Test One Step Closer

In the last couple of years research has emerged that could lead to a diagnostic test for ocular rosacea. There is currently no physical test that can definitively …

More Demodex Dreaming: Mites are the Chicken?

The NRS recently highlighted a paper speculating that demodex mites are the missing link in papulopustular rosacea, or as they characterised the mites are the “chicken coming first …

Aczone Fails to Impress for Rosacea

We don’t often get to see the actual results from clinical trials. Companies are happy to receive publicity for their research and development programs, especially if a new product looks promising. If things don’t go we during clinical trials, though, it …

Using a Hair Dryer to Pre-Flush before Pulse Dye Laser Treatment

This paper is promoting the use of a pre-flush to improve the outcome of Pulse Dye Laser (PDL)Rosacea Treatments. The authors suggest that by increasing the number of …

Novartis Must Drop Fougera’s Generic Metrogel

In May this year we learnt that Novartis would be buying Fougera Pharmaceuticals . One of the products that would come over to Novartis through this deal would be …

Does Finacea improve ND: YAG Laser Treatments?

Intendis, the makers of Finacea are to trial the combination of ND:Yag laser treatment with and without the addition of Finacea during treatment. As the study will be a spilt face trial, researchers will be able to show that the addition of Finacea does, or does not make a difference to the outcome of the laser treatment. The study wills assess acneiform lesions, …

Combine Brimonidine and Oxymetazoline, Why Not?

There is plenty of interest in two molecules that are in development to treat the redness and flushing of rosacea. Both Brimonidine and Oxymetazoline have been the subject of a lot of research and development efforts in the last 3-4 years. One of the ways that rosacea sufferers learn about progress in the state of the art of rosacea research such as new …

Topical Ivermectin

Rosacea and Sklice

Sklice is a new topical ivermectin 0.5% that is approved for the use of the scalp and hair for head lice.

Rosacea Support Links

 

• Tips for Getting Started
• Why, Oh Why Did I Get Rosacea?
• Frequently Asked Questions
• Just Diagnosed with Rosacea
• Top 5 Cheapest Rosacea Treatments
• The one thing I wish I was told about Treating Rosacea
• The BEST Treatment for Rosacea
• Treating Ocular Rosacea
• Official Rosacea Treatments
• Rosacea Treatments for Each Symptom

Rosacea News June 2012

1. Treating Rosacea with Collagen (Matricol)

Martricol, which is freeze dried sheets of collagen, is another example of a hopeful rosacea treatment emerging in a patent application. This time a health care company in …

2. “MetroFoam” is Better than Metrogel

OK the title is a bit of a stretch as currently there is no such product as Metrofoam, but keep reading to see where I’m coming from. Last year a patent surfaced, owned by Galderma, claiming rights to a “stable, metronidazole-based oil-in-water emulsion expandable into a topically applicable foam having a firm, creamy and light consistency” and is claimed to have improved release-penetration …

3. Demodex Bacteria Protein Response Isolated

Hot on the heels of a paper detailing the fact that demodex bacteria-based proteins inhibit corneal wound recovery, is this paper consolidating a direct relationship between an immune response and facial and ocular rosacea.

Recent research from 2007 has isolated 2 proteins from the bacteria from Bacillus oleronius, that …

4. Counting Demodex Mites with a Confocal Laser Microscope

This paper describes a new way of counting facial demodex mites. A type of microscope called a Confocal Laser Scanning Microscope was used to look for `roundish or lengthy cone-shaped structures’ on the skin, and these were …

5. Tanda Luxe (Red LEDs) for Facial Wrinkles and Cheek Rosacea

A clinical trial has been listed for the Tanda Luxe, a Red LED device that is to be used as a treatment for wrinkles and facial rosacea, especially on …

6. Wanted SF: Daily SPF15 Green Tint Corrector Trialists

I have been contacted by Yvonne Law from Biometrix, who are looking for volunteers in San Francisco who are interesting in trialing a new product from a well known cosmetic company. The product is a “facial SPF with green tint corrector to reduce facial redness”. The company says that this product is “now being researched for efficacy, safety in use, and advertising claim support." …

7. Allergan Developing Oxymetazoline (AGN-199201/V-101) Cream Formulations

A recently surfaced patent application shows that Allergan are continuing to protect their intellectual property around their proposed Oxymetazoline based facial redness treatment.

This patent application relates to the technology and inventions used to create a suitable cream formulation of oxymetazoline. It covers how …

8. Xeomin (Botulinum Toxin Type A) being Trialled as a Rosacea Treatment

The BOTOX relative Xeomin is to be trialled as a treatment on the cheeks of rosacea sufferers. We are not told in the trial description if the rosacea …

9. Elevated Proteins in The Skin of Ocular Rosacea Sufferers

The following abstract details some research that was undertake to characterise what is happening in ocular rosacea. There is currently no accepted diagnostic test for rosacea. Some History Rosacea News first highlighted a possible diagnostic test for ocular rosacea in late 2005. The article from the Journal of Proteome Research concluded that “The high abundance of oligosaccharides in the tear fluid of …

Rosacea News May 2012

1. Why Has No One Found a Cure for Rosacea?

Why has no one found something even remotely close to a cure for rosacea ? Why do researchers admit that they can barely even describe the disease ? Well a clue emerges from a recent series of in depth, state of the art papers from the Journal of Investigative Dermatology Symposium Proceedings. In the introductory item title  “Pathophysiology of Rosacea: Introduction”, Dr. Martin Steinhoff …

2. Scenesse Starts Phase III Trials for EPP in the US

News today that Scenesse has progressed another step towards wider approval with the commencement of Phase III Trials. About 100 people with the condition Erythropoietic Protoporphyria (EPP) will be double blinded to receive the Scenesse implant or placebo. …

3. Smokers Much Less Likely to get Rosacea

Yes you read correctly, some recent research conducted in the UK has found that smoking is associated with a substantially reduced risk of developing rosacea. The study …

4. How Much Would You Pay to Cure Your Rosacea?

Most published abstracts are a pretty dry read. This one is about as dry as they come. How about titling it “Rosacea Sufferers Willing To Pay Less than Vitiligo, …

5. Coblation with Saline and Radio Frequency Induced Plasma: Rhinophyma Miracle

The Daily Mail continues to show itself as the premier newspaper for rosacea related news stories. This last weekend the paper has a great …

6. Rosaliac AR Intense from La Roche-Posay

In 2010 La Roche Posay  took the opportunity of the rosacea awareness month and their support of the National Rosacea Society to promote their product – Rosaliac UV Fortifying Anti-Redness Moisturizer with SPF 15.

7. Novartis Buys Fougera for $1.5B, gets Generic Metrogel

News today that the giant pharmaceutical company Novartis International is buying Fougera Pharmaceuticals.

Fougera is known to rosacea sufferers through the availability of generic metronidazole 0.75%. Fougera will brings its specialty in generics to Sandoz, the generics division of Novartis.

Rosacea News January 2012

1. IPL Burns from Perth Home Operator

An article in this Weekend’s West Australian highlighting the dangers of IPL Treatments from untrained operators. This article is a reminder of the dangers of IPL in the wrong hands. Other warnings are, sadly, easy to find. Finding the right practitioner to treat you with IPL is not an easy task. This is a real dilemma for rosacea sufferers as we …

2. Taro Readying for Generic Metrogel 1%

A recently posted clinical trial suggests that Taro Pharmaceuticals is readying to gain approval to market Generic Metrogel 1%. Currently Generic Metrogel is only available in 0.75% strength. Taro Pharmaceuticals in fact already markets a generic form of Metrogel – Metronidazole Gel USP, 0.75% When the patent covering Metrogel 0.75% expired, Galderma changed the formulation, increased the concentration of metronidazole to 1% …

3. Patents Expire for Liptor and Zyprexa, Oracea Small Fry

While us in the rosacea world might consider products that are expensive while they are covered by exclusive patents, we are small fry in the drug market at large.

Patents are due to shortly expire for Pfizer’s Liptor and Lilly’s Zyprexa. Lilly can expect a $3bn drop in revenue just from generic forms  of Zyprexa becoming available. Pfizer is thought to have earned around $7.8bn from …

4. Metrogel 1% Pump; for those who don’t like a Tube?

Galderma have announced that Metrogel 1% will now be available in a 55gm Pump. Galderma are citing the benefits of a better looking dispenser, minimizing waste, easier compliance with prescribing instructions and “facilitating product handling”. Galderma received FDA …

5. 2011, The Year in Review

Happy New Year to everyone who reads Rosacea Support ! As we start 2012 lets look briefly at what was popular in the last year. …

Rosacea News February 2012

1. Treating Neurogenic Rosacea with ETS

Now that the collection of symptoms called Neurogenic Rosacea has become more widely known, new discussions can take place as, for example how to best treat it.

This recently published abstract details a patient who suffered debilitating facial redness and burning. The patient was treated with the invasive and possibly irreversible procedure Endoscopic Thoracic Sympathectomy. The patient had a good response to ETS.

2. Cyclosporin better than Artificial Tears for Ocular Rosacea

Skin and Allergy News has an article today highlighting the recent positive research into the usage of Cyclosporin as a treatment for Ocular Rosacea.

Dr. Harper mentions that she likes to include Oracea as an oral treatment for the worst of her ocular rosacea patients, but …

3. Get ready for Tinted Finacea

A recently surfaced patent assigned to Intendis suggests that we might soon see a Tinted Finacea reach the market.

According to the patent application, a tinted formulation of Finacea had improved anti-inflammatory effects compared to regular Finacea – “Surprisingly, it was found that there was a further marked reduction in cytokine release in the cultures treated with azelaic acid and titanium dioxide-coated potassium aluminium silicate 3%”.

4. Doxycycline can deactivate Cathelicidins

A recently published abstract from the house of Gallo suggests a clue as to how doxycycline might work in treating rosacea. The suggestion from this research is that doxycycline has a newly discovered mechanism of action whereby it is able to prevent the activation of cathelicidin.

Cathelicidin has been in the rosacea news since around 2002, gaining publicity because of the discoveries like the fact …

5. Maruho Acquires Cutanea Life Sciences

News this week that the Japanese company Maruho is to acquire Pennsylvania based Cutanea Life Sciences. Cutanea Life Sciences is developing Omiganan as a treatment for rosacea.
Maruho Co., Ltd. Acquires Cutanea Life Sciences, Inc.

6. Massive Rosacea Study (CD5024) Recruiting Underway

A large study looking at a treatment for the papules and pustules of rosacea is looking to recruit participants right across the US and Canada.

A web site just for this study has been created at www.pprstudy.com (Papulo – Pustular – Rosacea Study). On the site you can use your ZIP code to see if there is a study location close to you.

Rosacea News March 2012

1. Uriage Thermal Water for a Red Face (2012 AAD San Diego)

I have to admit that I had never heard of Uriage Thermal Water before reading this poster abstract. Best I can tell, Uriage Thermal Water is a mineral water sourced from the French Alps.  It “possesses an exceptionally high content of mineral salts and trace elements in comparison with thermal waters used in dermatology (i.e. 11,000 mg/l). These mineral salts and trace elements have …

2. La Roche-Posay and L’Oreal Sensitive Skin Research

Thought that the following Poster Session from the recent 2012 AAD Annual Meeting in San Diego was encouraging because we really do want to see new products being developed specifically for people with sensitive skin. La Roche Posay is one of the skincare brands owned by L’Oreal. La Roche Posay may be known to rosacea sufferers through the actually little-known Rosaliac UV …

3. Sansrosa Phase II Results at 2012 AAD San Diego

Some Phase II Trial results for Sansrosa were presented at the recent 2012 AAD Annual Meeting in San Diego. Joseph F. Fowler, M.D., Clinical Professor of Dermatology at the University of Louisville was the principal study investigator. A summary of these results was mentioned in October 2011 via a press release covered here: Sansrosa not Susceptible to Tolerance or Rebound Whilst …

4. Sulphur Still a Classic Treatment for Rosacea (2012 AAD San Diego)

The following Poster Session from the 2012 AAD meeting in San Diego aimed to raise the profile of the use of sulphur as a treatment in rosacea. Did you …

5. Frank C. Powell at 2012 AAD San Diego

If you were able to attend the 2012 annual meeting of the AAD in San Diego you would have been able to attend the following discussion group on Rosacea.  The director of the session, Prof. Powell is known to rosacea sufferers because of his excellent book Rosacea Diagnosis and Management. Powell has been a consultant dermatologist at the Mater Private Hospital in Dublin, …

6. Zinc Sulfate Doesn’t Work for Rosacea

Despite a 2006 study in a prestigious journal that showed some modest benefit from taking 100mg a day of Zinc Sufate, a more recent study with a …

7. Mysterious L’Oreal Lotion Good for Redness (2012 AAD San Diego)

At the recent AAD 2012 Annual Meeting in San Diego, a poster session sponsored by L’Oreal looked quite interesting. The session detailed some research on an un-named facial lotion. The research claimed a statistically significant improvement in redness after 4 weeks of use. No searching could find a product from L’Oreal that contained the following ingredients; palmitoyl tripeptide-8 …

8. Foamix Minocycline Foam works for Bacterial Infections

A recent press release teases rosacea sufferers that a topical foaming form of minocycline might become a new treatment. The trial results promoted in the press release are for a condition called Impetigo, …

9. Sansrosa Completes Phase III Trials

A short press release today from Galderma to say that the 2 Phase III trials for Sansrosa have completed successfully. These latest large scale trials were able to confirm the positive findings resulting from the Phase II trials. This must be a great relief to Galderma who had to return to Phase II trials after previously commencing Phase III trials. …

10. What about Acne in Children?

The following video from the American Acne & Rosacea Society will be interesting to those who are looking for more information about how to treat acne in children. Children require special attention when presenting with acne as some of the adult treatments may be unsuitable for children. The guidelines offer advice for adolescent acne, preadolescent acne, infantile and neonatal acne. …

11. Ziana Almost Works for Rosacea

In January 2009 we learnt that Medicis was interested in trialing Ziana as a treatment for rosacea. Medicis may be known to rosacea sufferers because they also make Plexion and Solodyn. Sadly the rigorous nature …

12. Avermectin Milbemycin Eyewash for Ocular Rosacea

This recently published patent is interesting for a couple of reasons. Firstly there is renewed interest in Ivermectin because of Galderma’s large trial of Topical Ivermectin 1% Cream (CD5024) for facial rosacea. Secondly there are few official treatments for ocular rosacea, so a provable treatment such as outlined in this patent could show promise. A word of caution is needed here of course. …

13. Azeloglicina (Azelaic Acid + Glycine) for the Redness of Rosacea

A newly published article introduces us to a new formulation of Azelaic Acid known as Azeloglicina. Azeloglicina (chemical name  Potassium Azeloyl Diglycinate) is described as a “condensation product between one mole of Azelaic Acid and two moles of Glycine” and is touted as an improvement over the individual properties of both. A company called Singerga holds the patent on Azeloglicina. …

Rosacea News April 2012

1. Demodex Bacteria Inhibits Corneal Wound Recovery

This just published abstract takes the demodex bacteria based irritation line of research a step further. Researchers in Ireland were able to show that demodex bacteria Bacillus oleronius proteins induced an “aberrant wound healing response” in  the cells irritated by scratch in a cornea. The aberration appeared as an elevated immune response and an chagnes in cells’ inability to move like normally …

2. Cetaphil DermaControl Oil Control Foam Wash and Moisturizer for Oily Skin

Cetaphil has launched 2 new products that are targeted at oily or acne-prone skin. The products are called, take a breath; Cetaphil DermaControl Oil Control Moisturiser SPF 30 and Cetaphil DermaControl Oil Control Foam Wash. The Oil Control Moisturizer is promoted as a lightweight 3-in-1 moisturizer for acne-prone skin. It is said to provide broad spectrum sun protection, control shine without over-drying. The SPF …

3. `My Naked Secret’ looking for Rosacea Sufferers

Live in the UK? Interesting in being a part in the My Naked Secret 2 series? The producers of this Channel 4 programme, who are based in London are looking …

4. Miranda from Sex and The City tells of her Rosacea

In a series of 6 videos, Cynthia Nixon who played Miranda in Sex and The City, talks about her battle with rosacea. The professionally produced videos point viewers to the …

5. Allergan Trialing Oxymetazoline for Facial Redness

A just-posted trial notification shows very early clinical trials by Allergan, for their product they have named AGN-199201. The double blind trial will compare 3 different formulations of AGN-199201 with with the vehicle. The decrease in redness …

6. Oracea Sales “Excellent”, Gaining Market Share

How much does Galderma earn each year from Oracea sales ? Well the actual amount is not published, but in September 2011 court proceedings we learnt that Mylan Pharmaceuticals projected sales of $260m in 2011 for Oracea. The parent company of Galderma, L’Oreal does not publish Oracea sales figures, so this press release is as close as you can find to something that …

7. “Medical Crowdsourcing” via CureTogether – the new cheap data collection method

A recent article in the Dermatology Online Journal introduced me to a new online support group site. Apparently curetogether.com is a major medical crowdsourcing site. What is crowdsourcing? Well crowdsourcing is a new buzzword which basically means to get your information from the “crowd” or as many people as you can. Online this term generally means something like “just asking everyone …

8. Oracea is Not an Antibiotic, Apparently

This claim from the Oracea web site caught my eye. Oracea is NOT an antibiotic. A bit of poetic marketing license perhaps?

Oracea is a 40mg dose of the antibiotic doxycycline, which is a member of the tetracycline family. 30mg of the dose of doxycycline is immediate release, and 10 mg is locked inside a coating that …

9. Theory: Ivermectin is Metrogel’s Cousin, Help Needed

OK, bear with me. I don’t often just waffle here as a Rosacea News item. Maybe I should. Anyway this post is just me exploring an idea. From my high school organic chemistry it seems to me that Ivermectin and Metrondizole are in fact chemically akin to cousins. I started to think about this because of the huge investment being undertaken by …

10. More Proof that CD5024 is Ivermectin

The mysterious CD5024 1% Cream for which Galderma is conducting a large Phase III trial, has further been confirmed as the anti-parasitic Ivermectin.

This latest confirmation comes from the World Heath Organisation’s International Clinical Trials Registry Platform Search Portal. The search for CD5024 reveals trials that have completed in the Czech Republic, Germany and Hungary. The register was created in 2006, the same year as when …

11. It would be hard to invent a more embarrassing disease than Rosacea

Thought this was a great line from a recent NRS Blog Posting: It would be hard to invent a more embarrassing disease than rosacea.  Nice. I’m sure many many rosacea sufferers would agree.

Cure and Banish Rosacea with junk ebooks

If you ever wanted to read Banish Rosacea by Robert Campbell then you don’t have to hand over any money just go to this link Rosacea Cure eBooks: All Just SPAM?. By the way, you won’t be surprised to learn that this spammy ebook wasn’t actually written by someone called Robert Campbell, it is just a made up name.

Also, there, you will find reviews of

• Rosacea, The Cure is in your kitchen by Ron Tramontano

• Cure Your Rosacea

• Autoimmune The Cause and Cure (Nature Had it First)

• Rosacea No More

• Rosacea Free Forever by Laura Taylor.

and a link to actually the book you should be buying.

Rosacea News December 2011

1. UV Exposure leads to Oxidative Stress

As researchers try to further describe exactly what is going on in rosacea, more tiny bits of information arise. Here, this abstract is telling us that; Ferritin positive cells are much more prevalent in rosacea sufferers Severe rosacea sufferers have significantly more ferritin positive cells Blood peroxide levels are higher in rosacea sufferers …

2. CD5024 Cream in Phase 3 Trials (Metrocream 1% ?)

Galderma has another rosacea-targeted treatment, until now undisclosed, in the final stages of approval. Hey – how come no one told me?

Could it be possible that the rosacea heavyweight Galderma has kept a new product so secret?
What is this CD5024?
Just what exactly is this CD5024 1% Cream? Galderma …

3. “Glaucoma Gel” Good for Redness: Daily Mail

The Daily Mail continues its interest in rosacea treatments with an article about an unnamed glaucoma treatment that has been formulated as a gel treatment for the redness of rosacea. Of course we know this treatment as Sansrosa. Other names we have seen over the years include COL-118 and CD07805/47. The active ingredient in the glaucoma treatment of mentioned …

4. Ocular Rosacea Video Worth a Watch

Thanks to a tip from Dori, on the Rosacea Support Group Email Group, here is a link to a video of a lecture giving a good overview of ocular rosacea and treatments.
Ocular Rosacea: Curse of the Celts and Celeb…

5. Finacea matches the pH of Skin so Penetrates Well

We know that the pH of skin is around 5.4. The makers of Finacea, Intendis have formulated Finacea to be pH of 4.8, which means that Finacea is reasonably close to the same pH as skin. One of …

6. IPL London Spa Burn Victim Awarded Tens of Thousands in Damages

In 2008 we heard about Charlotte Cripps, a writer for the The Independent was badly burned by an IPL treatment at a London Spa. Today we …

7. Treating Intestinal Bacteria with Xifaxan May Improve Rosacea

Some more recent publicity from Internal Medicine News on the possible link between Small Intestinal Bacteria Overgrowth (SIBO) and Rosacea. In 2008 Rosacea News highlighted a paper that suggested that treating patients with rosacea and SIBO with Rifaximin would improve both their SIBO and rosacea symptoms. That posting has attracted a lot of interest, heading towards 100 comments. Two threads …

8. Finacea Foam Trials Results Look Good

Some recent trial results confirm that Intendis are moving forward with the development of Finacea Foam. The summary of a recent trial, quoted in Skin and Allergy News shows that Finacea Foam is more effective at reducing rosacea symptoms compared to the inactive vehicle. This trial doesn’t show whether Finacea Foam is more effective than Finacea Gel, but does suggest that Finacea Foam likely to …

Rosacea News December 2011

1. UV Exposure leads to Oxidative Stress

As researchers try to further describe exactly what is going on in rosacea, more tiny bits of information arise. Here, this abstract is telling us that; Ferritin positive cells are much more prevalent in rosacea sufferers Severe rosacea sufferers have significantly more ferritin positive cells Blood peroxide levels are higher in rosacea sufferers …

2. CD5024 Cream in Phase 3 Trials (Metrocream 1% ?)

Galderma has another rosacea-targeted treatment, until now undisclosed, in the final stages of approval. Hey – how come no one told me?

Could it be possible that the rosacea heavyweight Galderma has kept a new product so secret?
What is this CD5024?
Just what exactly is this CD5024 1% Cream? Galderma …

3. “Glaucoma Gel” Good for Redness: Daily Mail

The Daily Mail continues its interest in rosacea treatments with an article about an unnamed glaucoma treatment that has been formulated as a gel treatment for the redness of rosacea. Of course we know this treatment as Sansrosa. Other names we have seen over the years include COL-118 and CD07805/47. The active ingredient in the glaucoma treatment of mentioned …

4. Ocular Rosacea Video Worth a Watch

Thanks to a tip from Dori, on the Rosacea Support Group Email Group, here is a link to a video of a lecture giving a good overview of ocular rosacea and treatments.
Ocular Rosacea: Curse of the Celts and Celeb…

5. Finacea matches the pH of Skin so Penetrates Well

We know that the pH of skin is around 5.4. The makers of Finacea, Intendis have formulated Finacea to be pH of 4.8, which means that Finacea is reasonably close to the same pH as skin. One of …

6. IPL London Spa Burn Victim Awarded Tens of Thousands in Damages

In 2008 we heard about Charlotte Cripps, a writer for the The Independent was badly burned by an IPL treatment at a London Spa. Today we …

7. Treating Intestinal Bacteria with Xifaxan May Improve Rosacea

December 6th, 2011, by David Pascoe | diet, rosacea cause | Edit

Some more recent publicity from Internal Medicine News on the possible link between Small Intestinal Bacteria Overgrowth (SIBO) and Rosacea. In 2008 Rosacea News highlighted a paper that suggested that treating patients with rosacea and SIBO with Rifaximin would improve both their SIBO and rosacea symptoms. That posting has attracted a lot of interest, heading towards 100 comments. Two threads …

8. Finacea Foam Trials Results Look Good

Some recent trial results confirm that Intendis are moving forward with the development of Finacea Foam. The summary of a recent trial, quoted in Skin and Allergy News shows that Finacea Foam is more effective at reducing rosacea symptoms compared to the inactive vehicle. This trial doesn’t show whether Finacea Foam is more effective than Finacea Gel, but does suggest that Finacea Foam likely to …

Rosacea News October 2011

Better late than never …

1. Demodex Infestation: the Missing Link ?

Firmly in the pure speculation category is a recent paper that proposes that pityriasis folliculorum (or demodex mite infestation) is the missing link in our understanding of rosacea. Plainly put, Dr. Forton, a dermatologist from Belgium, suggests that rosacea is a …

2. NRS highlights Neurologic form of Rosacea

The NRS Blog today mentions the recent publications that raise a possible new Subset of Rosacea. Even though this is just a passing reference, it is good to see that the NRS …

3. Elorac Patenting Oral Niacinamide + Oral Azelaic Acid (Finacea)

An unusual patent has surfaced that is suggesting the oral use of azelaic acid. Azelaic Acid is better known as the active ingredient in the topical finacea. This patent suggests an oral treatment that combines niacinamide with azelaic acid. The owner of the patent, Elorac is known from their recent trials of Carbamide Peroxide as a rosacea treatment. Finacea has received some …

4. Sansrosa not Susceptible to Tolerance or Rebound

Some news today from the Phase 2B Sansrosa Trials;

Galderma is now confirming that during the 8 week trial, participants did not suffer from tachyphylaxis or rebound.

This means that if you stop and start sanrosa or continue to use it for an extended period you likely won’t suffer from a rebound effect or from a reduced effectiveness.

This is some good news as it indicates the formulation …

5. Merck Trialling Laropiprant for the Redness of Rosacea

A product from Merck designated as MK-0524, also known as Laropiprant, is to be trialled as a treatment for the redness of rosacea. This is great news for rosacea …

6. Get ready for MetroFoam

A recently updated patent application by Galderma shows that they want to reserve the right to create a Metronidazole Foam product.

Galderma has a long history with topical metronidazole products, starting with Metrogel 0.75%, then adding Metrolotion and Metrocream, and when the patent on the 0.7% Metrogel expired, Galderma created Metrogel 1%.

Past research seems to suggest that it matters little whether you use Metrogel, Metrolotion, …

7. Niacin Flushes More when we are Worried About What Others Think

Continuing his research in facial flushing and anxiety, Dr. Peter Drummond from Murdoch University has published  some new research on social anxiety and facial flushing.

The trial found that Niacin, which is known to induce a facial flush, actually causes more flushing in people that worry about what others think of them.

By blinding participants to whether they were given Niacin or placebo, and measuring facial blood …

8. Powell: Randomized Clinical Trials are not the whole story

Writing in the British Journal of Dermatology, the well known Rosacea Researcher Professor Frank Powell says that research based on randomized clinical trials are not the be-all and end-all for rosacea research. He tells us that there is still room for other sorts of innovation, especially when seeking treatments from your dermatologist. Recently a Cochrane review of 58 clinical trials told us that …

9. Obagi Rosaclear may be better than Metrogel 0.75% + Standard Skincare

Another published abstract that appears to be building the case for the Rosaclear Integrated Rosacea Treatment from Obagi. Although the article …

10. News Shorts: Internet Anxiety, Food Hospital

Some quick links to items from around the web. 1. Internet Searching leads to greater anxiety for melanoma sufferers Of course everyone is now using the internet to read up on everything health related. You may be headed for some unnecessary anxiety though, so be careful. Internet Use and Anxiety in People with Melanoma and Nonmelanoma Skin Cancer …

Rosacea News November 2011

1. FDA Approved 35 New Drugs in FY 2011

The FDA announced today that the U.S. Food and Drug Administration approved 35 new medicines in fiscal year 2011. They included “important advances for patients, including: two new treatments for hepatitis C; a drug for late-stage prostate cancer; …

2. Topical Ivermectin + Metrogel from Galderma

An update to the 2009 filing of the patent covering preparations of Ivermectin and Metronidazole has emerged at the USPTO Patent Application Site. That application was in turn a followup to the original French language application 0505918 from 2005. The patent covers many different combinations of ivermectin and metronidazole such as emulsion, cream, gel with ivermectin present in an amount of from 0.01% to …

3. Amneal Pharmaceuticals joins the Generic Oracea War

News today of yet another company in the courts fighting against Galderma for the right to make Generic Oracea. Amneal Pharmaceuticals, based in Gujarat, India, a producer of generic …

4. Pineapple + Cottage Cheese, Get Bromelain from your fridge

Are you searching for a natural therapy to quickly relieve your symptoms? Would you be willing to try freshly crushed pineapple and cottage cheese on your face? Ellen …

5. Scenesse One Step Closer for Erythropoietic Protoporphyria (EPP)

News from Clinuvel that Scenesse (their implant of afamelanotide 16mg) has shown a provable positive effect on EPP sufferers in a US Phase 2 Trial. EPP is an acute intolerance to exposure to sunlight and UV. Sufferers of …

6. Accutane Gaining More Popularity

A new paper that highlights the progress made in recent years by researchers who are seeking to prove that accutane is a viable rosacea treatment.

This growing body of proof is actually quite important because oral isotretinoin is not officially approved as a treatment for rosacea. Doctors can prescribe accutane off-label for use in rosacea, so more comprehensive trials of accutane can only be a good thing. Further, the growing difficulty in finding a doctor who will actually prescribe accutane means that rosacea sufferers need all the proof that they can get their hands on.

Rosacea News September 2011

1. Sanofi-Pasteur to make an Acne Vaccine

A vaccine for acne ? Well it appears that one may actually become a reality. A recent article in the New Scientists explains how targeting a protein called CAMP can …

2. Galderma wanting to show Oracea Maintains Rosacea Remission

A recently posted proposed Clinical Trial has me thinking that Galderma wants to be able to market Oracea as a product to Maintain Rosacea Remission. First Some History …

3. Placebos Get Better Over Time: The Weird World of Placebos

More from the weird and wonderful world of clinical trials and the mysterious Placebo Effect. We know that somehow even dummy pills can kick-start the body’s recovery engine. This latest article from WIRED tells us that drug …

4. Diet and Acne: What the Latest Research Says

September 16th, 2011, by David Pascoe | acne treatments, diet | Edit

Over at the Acne Blog, Daniel Kern has posted a few high level posts relating to recent readings he has undertaken on the topic of diet and acne. Daniel …

5. Oracea set to generate $260m in 2011

An interesting note from the detailed interim judgement in the ongoing patent dispute between Galderma and Mylan. As part of the proceedings Mylan looked at the on-going Oracea sales and projected that Galderma can expect to receive around $260 million in 2011. MYLAN PHARMACEUTICALS INC., v.  GALDERMA LABORATORIES, L.P.; et. al. …

Rosacea News August 2011

1. Melanin also Protects You from Radiation !

Startling news today from the Clinuvel Blog: Melanin also has the ability to protect from radioactive emissions like X-rays and Gamma-rays. How interesting that the chemical that …

2. Mylan Violates The Chang Patent for Oracea

Another step in the ongoing battle between Galderma and Mylan over the right to manufacture generic Oracea. A judge has declared that Mylan infringes 1 of the patents that protects Oracea from generic copies. Some History …

3. How Much Sunscreen Should I Use?

Another fabulous data visualisation from Information is Beautiful. This time David McCandless tackles the thorny issue of How Much Suncreen Should I Wear ? The Sunscreen Smokescreen July 11, 2011 It started with a question. It always does. This time, the question was simple: How much sunscreen should I wear? I’m …

4. NRS Funds New Rosacea Studies for 2011

In the Summer 2011 Rosacea Review, The National Rosacea Society announced that they are funding 3 studies in new areas of rosacea research. This is great news; not only is the NRS continuing to fund 5 existing studies, it is funding …

5. NRS Continues Leading Edge Research Funding

The National Rosacea Society recently announced that they will be continuing to fund 5 existing rosacea research streams. Confirming their faith in the on-going NRS sponsored research, the NRS has announced additional funding to the following researchers. 1. Dr. …

6. Lupin and Medicis Agree Over Generic Solodyn

In contrast to the ongoing disputes over generic Oracea, the makers of the low-dose minocycline Solodyn, Medicis have entered into a joint development and sales agreement with Lupin Pharmaceuticals.

Solodyn is a form of Minocycline, a member of the tetracycline famaily, available in 8 strengths, prescribed based primarily on your weight.

7. Low Dose Accutane from St Thomas’ Hospital in London: Daily Mail

The Daily Mail has another of its semi-regular stories on Rosacea today. This time the article highlights the use of low dose accutane to treat hyper keratinisation, slow down sebum production, and also serve as an anti-inflammatory and anti-bacterial agent.

Rosacea News July 2011

1. Visualising Evidence for Oral Supplements: Snake Oil All Round

Below is a wonderfully rich graphic that tries to help visualise the available evidence for the efficacy of dozens of oral supplements. The aim of the creators is to visualise tangible health benefits when taken orally by an adult with a healthy diet. Only human, randomised placebo-controlled trials were used to create this graphic. Information is Beautiful: Snake Oil? …

2. Gallo to trial Aminocaproic Acid as Cathelicidin Inhibitor

Just posted are some details of a new trial rising out of the work of Dr. Richard Gallo’s group at the University of California, San Diego. Gallo is well known for his work on the relationship between antimicrobial peptides such as cathelicidin, and rosacea. The trial will compare topical 25% aminocaproic acid (ACA) mixed with Vanicream vs Vanicream on its own. The …

3. Allergan buying Vicept Therapeutics to get V-101 / Oxymetazoline

News today that Allergan are buying the privately held pharmaceutical company Vicept Therapuetics. The aim of many small startup companies is to be acquired by a larger company, Vicept telling us that “We believe Allergan …

4. Rosacea Cure eBooks: All Just SPAM?

There is a seedy dark side to the internet. OK you knew that already, but perhaps there are forces at play on the internet that are more subtle than you realise. Lets turn our focus toward the emergence of the “Rosacea Cure eBook” Phenomenon. Over the last few years there are more and more web sites that exist to solely sell you …

5. Metrogel, Finacea and Oracea are Best for Rosacea

A systematic review of the available rosacea research confirms that Metrogel, Finacea and Oracea are effective for moderate to severe rosacea. One study further found cyclosporine 0.05% ophthalmic emulsion effective for ocular rosacea. This review looked at the published results of 58 trials to note bias and construct a high level summary of the results. No Surprises Here It will come as …

6. Cosmetics and Makeup work fine applied after Metrogel

This research comes up with the finding that using a foundation after applying Metrogel 1% won’t worsen rosacea symptoms. Most of the participants in the trial were happy with the appearance of foundation, when used in combination with Metrogel.

The authors tell us that there is little research into whether makeup both makes rosacea worse or whether those who suffer from rosacea can also successfully use makeup like foundation.

Rosacea News June 2011

1. 9 New Drugs in Development for Rosacea

The Pharmaceutical Research and Manufacturers of America tells us that there are currently 9 drugs in development for rosacea. I was initially curious as to how counted nine. Read on if you want to see how they get to this number. 277 Medicines in Development For Skin Diseases Washington, D.C. (June 13, 2011) — America’s biopharmaceutical …

2. Why Do New Drugs take SO LONG to be Developed?

For everyone waiting on the latest and greatest new treatment for rosacea, new drugs seem to take forever to make it to the market. Taking a step back and looking at new drug development in general, it is very sobering to read how few drugs actually make it to an approved product; THE DRUG DISCOVERY , DEVELOPMENT AND …

3. Final FDA Approval of Sansrosa, expect 15 months post Phase III

A popular topic online at the various rosacea forums is to guess when Sansrosa will become available. So far all guesses have proved way way too optimistic. Given that we believe that the process is in the later stages of Phase III, what sort of best outcome possible, educated guess might be worth offering up? Once the Phase III process completes (which itself …

4. Riversol: From idea to a Rosacea Product

I thought this article from the Vancouver Sun was quite interesting from the point of view of developing new products for rosacea sufferers. Just how do you get from something that you think might work, to a product …

5. Galderma blocking Impax making Generic Oracea

The last we heard from Impax Laboratories was in late 2009 when they had filed an Abbreviated New Drug  Application (ANDA 91-447) to produce a generic version of Oracea. …

6. Inactive Ingredients Just as Important as Active Ingredients

Rosacea sufferers get good at looking through ingredient listings. What magical ingredient has been included in this product that might help me? But you should keep reading and take notice of everything listed.

7. How do you cope with Rosacea at Work?

The NRS recently highlighted the possible negative effects of rosacea in the workplace and on their career.

As well any physical symptoms such as facial burning, blurred vision and debilitating flushing, the secondary worries about what others will think about your appearance make it tough for rosacea sufferers at work.

Rosacea News May 2011

1. Custom Cleanser and Moisturizer from acne.org

The owner of the site acne.org, Daniel Kern has created an acne treatment regime that is cheap and simple. It looks to me like any benefits to rosacea sufferers are yet to be discovered. acne.org is a large online community of acne suffers that includes a small area for rosacea sufferers. The site is run mostly by volunteers and doesn’t accept any …

2. Most Patients use Steroids for Trivial Problems

Steroid Induced Rosacea is, sadly, one hot topic.

I know this because the blog posting Treating Steroid Induced Rosacea is one of the most visited pages on this site, and is currently approaching 1000 comments. Unfortunately many …

3. Sansrosa Parallel Phase III Safety and Efficacy Trial Announced

News today of a parallel Sansrosa Phase III Trial. This just announced trial is shorter than the Long Term (52 week) Safety Trial, and seeks to confirm that Sansrosa Gel (CD07805/47) is more effective than the inactive vehicle gel and is itself a safe treatment. Trial ID: NCT01355458 (seems to be somewhat duplicated with NCT01355471) …

4. Vanicream Moisturizing Skin Cream User Reviews

I harp on about this a lot, but I think it is worth repeating. A gentle skin care regime is a good thing for your rosacea. We know …

5. Tetrapeptide-14: Now available for Eye Puffiness and Redness

Some news today promoting a product claimed to reduce the appearance of under eye puffiness. Tarte Dark Circle Defense claims the inclusion of a Helix Biomedix designed peptide sequence known as Tetrapeptide-14 is responsible for the anti-inflammatory actions of the concealer.

6. AzaClear: Moisturizer with Azelaic Acid and Niacinamide

Epikinetics Pharma has pushed out a press release today (reproduced in full on sfgate.com …

7. Why should I Cleanse and Moisturize my dry, oily, flaky SD skin?

I came across this thread in the archives and thought it was worth highlighting it and pushing it out again.

The question asked is a good one – how can cleansing and moisturizing the dry flaky and oily SD skin be a good thing? If you have ever wondered why this is so, read on.

It was interesting to read again how for severely sensitive skin, repairing …

8. FTC Gets Tough on Acai Berry Supplement Sites

Recently the Federal Trade Commission announced that it was taking legal action against businesses that operate deceptive supplement web sites, specifically sites that selling Acai Berry based products.
What does this have to do with Rosacea?
A fair question. As the internet has become a more and more popular source for health related information, the trustworthiness of web sites has become more and more important.

9. Atopiclair, Eletone, MimyX: Barrier Creams with No Active Ingredients

Thanks to Beth, here is some more information about a class of FDA Approved “Medical Device” creams. This class of creams are prescription only, contain no active molecules and are approved for sale to treat medical conditions under via the provisions of …

Rosacea News April 2011

Rosacea News April 2011

1. LA Clinic looking for Oracea Biomarkers Study Participants

The Vitligo and Pigmentation Institute of Southern California is hosting part of the trial to evaluate Rosacea-related Inflammatory Biochemical Markers in Adult Skin When Treated With Oracea  vs Placebo. This trial is looking to prove changes in inflammatory markers like the peptide LL-37 and the MMP family match the improvement seen when taking Oracea. The trial is scheduled to involve 170 participants at …

2. Why, Oh Why Did I Get Rosacea ?

I hear you.

My skin was great. I have had beautiful skin all my life, but now wham! rosacea has reared its ugly head.

Well the NRS Blog has an answer to this plea. It is all about your risk profile. If you are over 30 with fair skin, have a relative with rosacea and are of Northern European Ancestry then the statistics suggest that you are …

3. Galderma Big Profits Great for Texas

An interesting article from the Business section of the Star-Telegram about the local presence of Galderma in Fort Worth, Texas. Galderma is one of the key companies for rosacea sufferers to follow given their products such as Cetaphil, Metrogel, Oracea and the in-development Sansrosa. Swiss skin-care company thrives even during hard times, executive notes at …

4. Vicept Oxymetazoline V-101 Cream More Phase II Data, on to Phase III

A Press Release today (Vicept are happy to generate publicity at every step of their development) touting more Phase II Study results for their Oxymetazoline based V-101 product. V-101 is a topical slated to treat the redness of …

5. The BEST Treatment for Rosacea

Once you have been diagnosed with rosacea, everyone naturally wants to know What is the best treatment for rosacea? Wouldn’t it be great if there was a simple answer to this question that satisfied everyone who has rosacea! Hopefully it doesn’t come as a surprise to find out that there is no known panacea for rosacea. This high level paper …

6. Generic Oracea Legal Trial now in July 2011

I have been watching for a while to see for any developments in the legal proceedings between Mylan and Galderma. These proceedings will determine whether Mylan is allowed to sell Generic Oracea. This is of interest to many rosacea sufferers who consider that Oracea is too …

7. Medicis and Anacor to Develop Boron Treatments for Acne

Even though this press release relates to Acne, it is still interesting to see companies searching for the next killer acne treatment. Whilst only some acne treatments are successful as rosacea treatments, we can still …

8. Green Jelly Beans Linked to Acne!

OK so now I have gotten your attention. Have read of this comic. Lets talk after you finish reading it. xkcd: Significant …

9. Nailfold Capillaroscopy: If only Rosacea was that Easy to Diagnose

I thought this abstract was interesting because of its failure. The authors proposed that a passive diagnostic test known as Nailfold Cappillaroscopy could be used to test for rosacea.