Tuesday, April 01, 2008

Rosacea News March 2008

1. Pyratine-6 Now Available from physicians

The Anti-Aging product Pyratine-6 is now available to buy from some physicians. Pyratine-6 is a new product that is a derivative of Kinetin. Their new web site has launched at pyratine-6.com. You can find a stockist on their web site.

2. angiogenesis: lymphatic and mast cell involvement

The pathogenesis (how a disease progresses from mild to severe forms) of rosacea is a complicated and poorly understood process. Likewise the growth of new blood vessels, thought to be important in the development of rosacea, is also a complicated and mysterious process. The NRS has updated their blog with an Update on Angiogenesis.

3. Sansrosa Phase 3 Delayed until END of 2008

According to the just published earnings call, Collagenex have been asked to undertake a additional Phase 2 study before commencing Phase 3. These additional studies will take several months, delaying the start of Phase 3. Collagenex are still hopeful of commencing Phase 3 studies some time before the end of 2008. These additional studies are to confirm that the diseased rosacea skin does not allow …

4. Prosacea User Reviews

Prosacea is a topical gel, available over the counter at stores like Walgreens. Prosacea is only briefly mentioned in the online support groups. Below is a hopefully balanced selection of user comments from rosacea sufferers who have tried Prosacea.

5. moderate exercise may help your rosacea

Some rosacea sufferers report good results if they exercise moderately but regularly. It is well known that regular exercise is good for stress relief and of course your general well being. But what about improving your skin ? Is that possible ? This paper is suggesting that exercise can reduce the amount of cytokines generated as part of the inflammatory response that is believed to …

6. The Warm Room Flush: what you wished you always knew

You may have noticed that your face flushes when you enter a warm room, but have you ever thought about how that process actually works ? Well, a nicely written article just released on the web goes into detail about how your body responds when you go from a cold room to a warm room. Colin Dahl, rosacea sufferer himself, from Australian Sciences has created this article to help rosacea sufferers understand the thermoregulatory roots of facial flushing in a simple, easy to read manner. The following couple of paragraphs from Chapter 1 give an accurate description of the contents of the booklet.

Monday, March 10, 2008

Rosacea News February 2008

1. News anchor gets burned by photo facial

From: Lucy Noland offers tip for others to avoid the same pain. 11 News anchor Lucy Noland wanted to share her personal experience so that others can avoid getting burned. A few weeks ago, I went in to get some freckles removed. The result? I was left burned so badly that I couldn’t work for a week. From the bright …
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2. Galderma buys CollaGenex for $420m

Collagenex is set to become a subsidiary of the much bigger Galderma, after CollaGenex agreed to a merger. So 2 of the biggest pharmaceutical companies involved with make rosacea treatments are to become the same company. Galderma has long been associated with rosacea treatment, and is best known for the metronidazole based topicals metrogel, metrocream and metrolotion. CollaGenex has become known in recent years …

3. finacea is good for acne and hyper pigmentation as well

This poster session is seeking to expand the appeal of Finacea (which contains Azelaic acid 15%) beyond rosacea. The result is that the authors are suggesting that finacea is also possibly good for acne vulgaris and hyperpigmentation as well as rosacea. If you are …

4. NRS updates their FAQ

The National Rosacea Society has updated their Frequently Asked Questions page, as reviewed and edited by Dr. Mark Dahl (who is on the Medical Advisory Board of the NRS). They have included 44 questions ranging from `What causes rosacea’ to `Do steroids induce rosacea’. Publications from the NRS are carefully written to be neutral and to be of good general interest. For those …

5. Collagenex CEO says rebound not yet seen in Sansrosa

February 21st, 2008, by Ben

Regarding another investor conference today, CEO Colin Stewart presented and most of the information was familiar. However, during the question period, an audience member asked about rebound flushing/redness during the Sansrosa / COL-118 trials. The following is what was said:

Man: “I realize that it’s an in-class, COL-118, it’s kind of difficult to work out the economics of the opportunity. Now, the fact …

6. Clarisonic user reviews

With the recent push by Clarisonic to promote their sonic brush as treatment for rosacea, I thought it might be interesting to see some reviews of users of the Clarisonic Skin Care System by rosacea sufferers. Although it is expensive, it does seem to be working quite well and so far no-one is reporting that it has irritated their …
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7. using a sonic brush to treat rosacea and seb derm

Here are 2 more recent Poster Sessions promoting the usage of the Clarisonic Skin Care System. Previous publications addressed treating seborrheic dermatitis with the Clarisonic brush. The manufacturers are now targeting their sonic brush as a treatment for rosacea itself. These papers are readying Clarisonic’s push into treating rosacea. It is an interesting idea to approach cleansing from …

8. LED helps recovery after IPL, reduces redness

This paper is good news for both those undergoing IPL treatments and those interested in Light Emitting Diode (LED) therapy as a anti-redness treatment. Patients treated immediately after IPL with a LED device showed that their post-treatment redness subsided faster compared to not also being treated with LED. Use of light-emitting diode photomodulation to reduce erythema and discomfort …

9. Malassezia Globosa causes seborrhea, Pyrithione Zinc is effective

Interesting threads on the Rosacea Support Forum started by Artist. Apparently it is well known but it was a surprise to me that seborrheic dermatitis is not caused by Pityrosporum ovale, but in fact Malassezia Globosa. The second bit of information that was surprising to me was not only that ketoconazole is effective against M. Globosa, but so is Pyrithione Zinc (PTZ). Some great links …

10. rosacure helps redness after 1 month

This paper looks to be suggesting that the silymarin/msm containing topical, rosacure/synchrorose was well tolerated and helps with the redness of rosacea. Silibinin (INN) (silybin, Legalon®) is the major active constituent of silymarin, the mixture of flavonolignans extracted from plant Milk thistle. Methylsulfonylmethane (MSM, or dimethylsulfone) is an organic sulfur compound belonging to a class of chemicals known as …

11. oral repeat prescriptions more popular than topicals

This paper comes up with the seemingly simple and innocuous result that rosacea sufferers are more likely to fill prescription repeats for oral treatments compared to topicals. This lead to the suggestion by Collagenex that sufferers are generally more satisfied with the effects of oral treatments. In recent press release they further suggested that this was a reason that the market for Oracea was large …

12. aveeno ultra calming with feverfew well tolerated

This paper was sponsored by Johnson & Johnson, who make the Aveeno Active Naturals Ultra Calming range. J&J are attempting to target rosacea sufferers with their aveeno range that contains feverfew. Rosacea sufferers are difficult to target with cosmetics so it is encouraging to see large companies doing background research to create suitable products. Poster Abstracts, American Academy of Dermatology 66th Annual Meeting, February … 

13. oxymetazoline good for 6 hours and safe for 3 months

This poster abstract is an update to the paper that was published in Archives of Dermatology in 2007 and was covered by Rosacea News as Sansrosa’s sister to enter redness race. This now expanded abstract suggests that oxymetazoline is effective for up to 6 hours after application and no side effects have been seen after 3 months usage. …

Sunday, March 02, 2008

The Warm Room Flush: what you wished you always knew

You may have noticed that your face flushes when you enter a warm room, but have you ever thought about how that process actually works ? Well, a nicely written article just released on the web goes into detail about how your body responds when you go from a cold room to a warm room. Colin Dahl, rosacea sufferer himself, from Australian Sciences has created this article to help rosacea sufferers understand the thermoregulatory roots of facial flushing in a simple, easy to read manner. The following couple of paragraphs from Chapter 1 give an accurate description of the contents of the booklet.

A Practical Understanding of Rosacea, Part 1: Heat Regulation and the Warm Room Flush Phenomenon, By Colin Dahl, Chief Scientist, Australian Sciences.

The simplified biological mechanics of rosacea have been explained in the booklet. Minimal medical terms have been used and may be further referenced online. I believe that a basic understanding of how the body deals with heat regulation and dilation of blood vessels is needed if you want to begin reversing this and other forms of facial flushing associated with rosacea.

It is not the intention of this booklet to name or deal with specific chemicals. The reason for this is simple, once you have excessive blood vessels and nerves in your skin, you will have an excess of numerous inflammatory chemicals. It is the intention of this booklet to highlight the systems involved, so that these systems can be used in your favor.

Often we see terms like nerve-mediated vasodilation, cutaneous nerves, angiogenesis (and a new one axonogenesis), sympathetic nerves, neurotransmitters, neuropeptides, nerve growth factors etc. thrown around. Finally here is a document that puts them together in context. Whatsmore, it is a pleasure to read.

I like that the document doesn't suggest that IPL is the end-game for treating flushing. See the document for Mr. Dahl's thoughts on how to enhance the effectiveness of IPL therapy.

If you go to the Products section of the web site you will also see that Australian Sciences have products related to rosacea in the development pipeline. From the PDF;

Australian Sciences is developing a range of effective products aimed at assisting in the reduction of excessive skin cell activity due to environmental factors such as sun exposure. Australian Sciences has conducted extensive research into the normalization of inflammatory skin cells with natural compounds such as silymarin, egcg, vitamin B12 and many others. Independent research has also showed these compounds to be effective for other inflammatory skin disorders such as atopic dermatitis and psoriasis. We believe these products can help normalize skin cells and assist in the long-term reversal of excessive skin infrastructure.

Further benefits can be achieved through reducing the exposure of skin cells to environmental factors. A major contributor to excessive skin cell activity is sunlight. Not only is the ultraviolet radiation a major contributor, but the excessive heat energy delivered to skin cells is enough on its own to cause problems for those with rosacea.

Stay tuned for further information.

Read the document here: Australian Sciences Rosacea Page.

What do you think about this document ? Leave a comment below or discuss it online at the Blushing and Flushing Forum at the Rosacea Support Forum.

Related Articles

Tuesday, February 05, 2008

Rosacea News January 2008

Rosacea News January 2008

1. most popular blog posts in 2007

January 2nd, 2008, by Digital Davo, in the news

Looking through my web site statistics I can see that the following Rosacea News items received the most visits during the year. I’m looking forward to 2008 to see what makes the Rosacea News. 1. eucerin redness relief product reviews In 2005 a new range of skin care products from Eucerin (Beiersdorf Inc) called Eucerin Redness Relief was released. ...

2. not on your face, it is possible

January 8th, 2008, by Digital Davo, accutane, macrolides, papules & pustules, steroids

One often asked question by newly diagnosed sufferers is `can you get rosacea on areas other than your face’. The usual answer is no; you normally only see rosacea symptoms on the flushing zone areas in the central areas of your face. This paper slightly dispels this idea with a case report about one patient who had rosacea lesions on his arm, and upper chest …

3. AAD Poster Sessions: oxymetazoline

January 16th, 2008, by Digital Davo, in the news, research

The 66th Annual Meeting of the American Academy of Dermatology is due to take place in San Antonio, TX, from Feb 1-5. Of most interest to rosacea sufferers is the poster sessions where recently published research and related products are promoted to dermatologists. Based on the proposed poster sessions, the following look interesting. P400: Successful treatment of the erythema and flushing of rosacea using a …

4. NRS announces 2008 research grants

January 17th, 2008, by Digital Davo, research foundation

The NRS has announced four new grants for ongoing research into the knowledge, cause and treatment of rosacea. Dr. Gallo, Dr. Granstein and Dr. Steinhoff have been awarded grants to continue their existing NRS-funded research while Dr. Helfrich has been awarded a grant for new areas of funding. Briefly, (for full details, see the NRS Blog): Dr. Richard Gallo, …

5. 100mg doxycycline no better than oracea

January 18th, 2008, by Digital Davo, doxycycline, oracea

Collagenex is reporting today that Oracea is equally effective as 100mg of doxycycline. This latest press release is a culmination of a trial that we have reported previously - oracea plus metrogel, better than 100mg doxycycline plus metrogel ? and also a 2007 SkinMed paper; maximum effective dose of doxycycline is 40mg a day. The main point of the trial was …

6. Clinique Redness Solutions: user reviews

January 22nd, 2008, by Digital Davo, cleansers, moisturizers, topicals

A new range of products for problem red skin called Clinique Redness Solutions has recently been launched.

The range consists of ; Redness Solutions Urgent Relief Cream is said “rushes soothing relief to upset skin. Quickly calms flare-ups of visible redness, irritation.” Redness Solutions Daily Protective Base SPF 15 is claimed “Protects …

7. Clinique Redness Solutions Ingredients

January 24th, 2008, by Digital Davo, steroids, topicals

A recent Rosacea News post listing the some preliminary user reviews for Clinique Redness Solutions was unclear on whether the Urgent Relief Cream contains cortisone. Well the answer is yes, it does. This would suggest that this product is not suitable for long term use for rosacea sufferers. It is not a surprise that a product that claims up soothe upset skin would …

8. otophyma: rosacea swelling and growth of the ears

January 27th, 2008, by Digital Davo, rhinophyma

Hot on the tails of the recent paper about getting rosacea on areas other than your face comes this paper about rosacea related swelling and growth of the ear. This case report covers a patient who had an enlarged ear which was found to be caused by the same sort of rosacea growth seen in rhinophyma - called lymphedema. An additional suggestion is that …

9. granulomatous variant not a rosacea subtype

January 29th, 2008, by Digital Davo, research

This just published paper is confirm that belief that the granulomatous forms of rosacea are not genuine subtypes in the same ways as the 4 well-know subtypes: ER, PP, PHY and OC (my abbreviations). A one-line summary of this paper is that a group of patients who had tests to show that they had granulomatous rosacea did not have any …

Tuesday, January 01, 2008

Rosacea News December 2007

1. Senetek Trialling Pyratine 6 / PRK124

December 30th, 2007, by Digital Davo | clinical trials, papules & pustules

A new trial has just been posted that will be looking at how Pyratine 6 (a variant of Kinetin) treats the papules & pustules, redness and visible blood vessels of rosacea. From Clinical Trial NCT00580723: Effects of PRK 124 Lotion in Acne Rosacea The purpose of this open-label study is to determine the tolerance and efficacy of twice-daily application …

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2. Nerve Growth Factor inhibitor - acerola seed extract

December 27th, 2007, by Digital Davo | patents, seborrheic dermatitis

Trawling patent applications is challenging but also interesting. There is a huge mine of information available for us to scavenge information that might lead to future treatments. I thought this patent was interesting because it deals with something that I hadn’t heard of before, but seems like it might have some potential. This patent application makes me wonder if we will see anything else …

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3. acne lotion good for cleaning pen from toys

December 21st, 2007, by Digital Davo | acne treatments, in the news

OK a semi-serious post for this time of year. An interesting blog posting over at Baby Toolkit suggests that 10% benzyl peroxide cream and sunlight is perfect for removing pen marks from a plastic doll. From Clear Unsightly Blemishes: the Case of the Ballpoint Baby Doll Here is before ;   and here is after …

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4. Patents abound for treating rosacea with alpha agonists

December 19th, 2007, by Ben | patents

Their has been much talk lately about using alpha adrenoceptor agonists as rosacea treatments because they show vasoconstrictor actions. Some examples are brimonidine, oxymetazoline, naphazoline, and others.

There are quite a few patents out there discussing these, and even testing some of them. Some of these patents have been mentioned before on the site.

Here are links to some of these patents.

US20040242588
Compounds, …

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5. kinetin & niacinamide for anti-aging

December 14th, 2007, by Digital Davo | moisturizers, topicals 

This study shows that kinetin and niacinamide work together well to provide anti-aging effects for asian skin. Previous studies that have been highlighted by Rosacea News have also shown that topical kinetin is a good anti-aging moisturizer for rosacea sufferers and may even show some benefit for rosacea symptoms. The clinical anti-aging effects of topical kinetin …

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6. get ready for ocular oracea

December 12th, 2007, by Digital Davo | doxycycline, ocular rosacea, oracea

Thanks for the tip from Ben. A clinical trial listed for treating both facial and ocular rosacea with Oracea suggests that Oracea might soon be marketed directly as an ocular rosacea treatment. This phase 2 trial’s purpose is to determine the safety and efficacy of sub-antimicrobial dose doxycycline in the treatment of patients who have both blepharitis and facial rosacea. The trial …

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7. FDA approves Lyrica for Fibromyalgia

December 10th, 2007, by Digital Davo | in the news

Whilst this was announced back in June this year, I thought it was worthwhile highlighting it here in case it is of interest to rosacea sufferers who also suffer from chronic pain. From the FDA Consumer Update: Living with Fibromyalgia, First Drug Approved People with fibromyalgia have typically turned to pain medicines, antidepressants, muscle relaxants, and sleep medicines. On …

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8. how Collagenex are Promoting Oracea

December 6th, 2007, by Digital Davo | oracea, tetracyclines

A recent investor presentation from Collagenex shows some interesting insights into how Collagenex are promoting Oracea. Oracea is promoted as safe and effective for long term use. It was reported that the average duration of Oracea therapy is 4 months, compared to an average of 2.5 months for other rosacea prescriptions. 52% of Oracea prescriptions are refills - the presentation suggests that …

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9. treating ocular rosacea with amniotic membrane transplant

December 4th, 2007, by Digital Davo | ocular rosacea

This case report of one patient shows a remarkable treatment possibility for severe ocular rosacea. The patient also suffered from papulopustular rosacea and rhinophyma and did not respond to full dose doxycycline. Three attempts to glue his perforated cornea failed. The paper suggests that corneal perforation is quite rare in ocular rosacea.

The amniotic membrane transplant was a success, both sealing the perforation, and restoring good …

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10. genetic links for psoriasis, lupus

December 3rd, 2007, by Digital Davo | research

A quick news bite about some new links found for a genetic root for psoriasis and lupus. I like that the reporter doesn’t try to dress up this announcement as anything other than a small advance in our knowledge of these 2 diseases. The research into a provable genetic link for rosacea symptoms is still at a very early stage. Maybe one day …

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most popular blog posts in 2007

Looking through my web site statistics I can see that the following Rosacea News items received the most visits during the year.

I'm looking forward to 2008 to see what makes the Rosacea News.

1. eucerin redness relief product reviews

In 2005 a new range of skin care products from Eucerin (Beiersdorf Inc) called Eucerin Redness Relief was released. They are claimed as “Safe for sensitive skin and appropriate for Rosacea”.

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2. how to cure a red face

Many rosacea sufferers are looking for help to reduce the redness of their face. This is one of the first rosacea symptoms that people might notice. What treatments have fellow rosacea sufferers used to hide the ruddiness and angry face that sometimes accompanies rosacea ? I’ll go through what I see as your current best options.

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3. choosing a moisturizer

An excellent consumer report about how to choose a moisturizer. The article gives some background on how moisturizers are formulated, how they work, and the operation of common active ingredients. A table at the end of this document compares about 75 available moisturizers, classifying them under Face, Hands and Feet. Highly valuable for anyone searching for a moisturizer as part of their daily routine.

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4. treating rosacea with herbs

There is a lot of interest from rosacea sufferers in treating their rosacea with natural or herbal therapies and remedies. Many are keen to avoid treatments like antibiotics and metrogel. This paper is by far the best collection of information about natural products I’ve found.

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5. red face: when flushing isn't rosacea

This paper explores the different problems that may be causing flushing. The list of possible reasons other than rosacea is extensive. The author was kind enough provide a full copy of this paper, so contact me if you’d like to read it.

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6. focus on finacea

Finacea is a topical rosacea treatment made by Intendis. Its main active ingredient is azelaic acid 15%. Officially, finacea “is a topical treatment for the inflammatory bumps and lesions of mild to moderate rosacea”.

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7. periostat goes generic, get ready for oracea:

Periostat (20 mgs doxycycline hyclate) has been helpful to some rosacea sufferers. Originally developed to combat periodontal disease (gum disease), periostat was approved by the FDA in 1998. Recently the FDA approved the introduction of generic periostat equivalents.

Oracea contains doxycycline, the same active ingredient as CollaGenex’s gum disease treatment Periostat. CollaGenex is shifting its focus to the dermatology market following the approval of generic competition for Periostat.

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8. ocular demodex - tea tree oil as a treatment:

This recently published paper suggests that a variety of ocular symptoms might be caused by demodex infestation. Six patients all having demodex present, and suffering with recalcitrant symptoms (including 4 diagnosed with rosacea) were given tea tree oil for a weekly eyelid scrub and tea tree shampoo for a daily scrub.

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9. focus on metronidazole

Metronidazole is a prescription drug that is available in several formulations. As an oral treatment it is known as flagyl. Topical metronidazole is available as noritate, metrogel, rozex, metrogel 1%, metrolotion and metrocream.

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10. focus on low dose accutane:

The mechanism by which low dose accutane (isotretinoin) i.e. around 10mg a day, is effective in treating rosacea is not clearly understood. Just the name accutane is enough to strike fear into many doctors and patients.

Hopefully the following articles will provide some pointers to useful information when researching whether accutane/roaccutane is a suitable treatment for your rosacea.

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Thursday, December 06, 2007

Rosacea News November 2007

1. COL-118/Sansrosa $150+ a month ?

A recent investor presentation from Collagenex gives some hints as to how Collagenex will price COL-118. Collagenex believe that their anti erythema product used for  2-4 months of treatment at $150 a month leads to a $330-660 million market. $150 a month for COL-118 treatment sounds like a lot. One wonders how much the suggested $150 a month will translate to at the pharmacy counter.

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2. Sansrosa’s sister to enter redness race

PubMed pushed out an interesting abstract in the last couple of days. A bit of digging reveals what looks to be a running mate for COL-118/Sansrosa. COL-118 and Oxymetazoline appear to be promoted by separate groups of researchers. This is good news for rosacea sufferers as it means there may well be a choice between 2 topicals that can help address the redness and flushing of rosacea.

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3. aspirin for flushing says Dr. Bikowski

Alluding to a link between rosacea and migraines, Dr. Joseph Bikowski says that aspirin should be the first line of defense against rosacea flushing. A recent article in Dermatology Times highlights the potential benefits (and risks) of taking low doses of aspirin long term for rosacea swelling and flushing.

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4. Clinuvel trialling CUV1647 (melanotan) for skin cancer for transplantees

Getting some press in Australia currently is a story about a trial starting today in Melbourne. The trial will assess the efficacy of CUV1647 (also known as melanotan) to protect against skin cancer in patients who have had organ transplants. Patients who have received organ transplants are at a much higher risk of contracting skin cancer because of the immune suppressive drugs that they must take.

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Tuesday, November 06, 2007

Rosacea News October 2007

Rosacea News October 2007

1. the best moisturisers with sunscreen

I love CHOICE Magazine in Australia. They do great reviews, always concentrating on practical outcomes. A recent report dealt with moisturisers (yes we spell them with an "s") on the Australian market that also contain sunscreen. For those that want both the protection offered by a sunscreen and a good moisturizer, this report is for you.

2. ivermectin clears untreatable rosacea

In this case report of one patient, the papules and pustules of rosacea were difficult to treat until oral ivermectin was included in the treatment regime. This 2007 paper is similar to a 2002 paper, Treatment of rosacea-like demodicidosis with oral ivermectin and topical permethrin cream. The 2002 paper is also a case report of a single patient with recalcitrant symptoms

3. spotlight on rosacure (synchrorose) silymarin + MSM, user reviews

Rosacure has been around for a while and is easily available, but it seems that only a few rosacea-support members rave about it. The products genesis and marketing are  good, so lets look at some of the available background information and product reviews.

4. measuring ocular rosacea severity

The National Rosacea Society has today posted a blog item about some new research into wanting to quantify the severity of ocular rosacea symptoms. From Scoring Aids Eye Research The new questionnaire, called the Severity Criteria of Ocular Rosacea (SCOR), includes more than 25 signs and symptoms of ocular rosacea observed by both physician and patient, including eye dryness, tearing and burning; history ...

5. tinted moisturizers, ever tried them ?

A great thread has been started at the Rosacea Support Forum on tinted moisturizers. The poster mimicocolulu has been writing some great posts lately. Here, in the new Makeup and Cover Up forum, she gives us the low down on how tinted moisturizers can work well for rosacea sufferers.

Wednesday, October 03, 2007

Rosacea News September 2007

1. how metrogel works II - free oxygen radicals

Another recently published paper that seeks to understand the role of Reactive Oxygen Species in the development of rosacea. The inflammatory pathway that leads to rosacea symptoms is slowing gaining more and more attention. All rosacea sufferers should do themselves a favor and do some reading on the role of inflammation in rosacea.

http://rosacea-support.org/how-metrogel-works-ii-free-oxygen-radicals.html

2. Melanocorp gets warning from FDA for melanotan II

Looks like the FDA has finally caught up with Melanocorp for selling Melanotan II over the internet. Their web site currently down. "FDA Issues Warning Letter to Melanocorp, Inc. For Illegal Sale of Melanotan II Melanocorp, Inc. advertises the product Melanotan II on its Web site as an injectable tanning product, with additional claims that it is effective in protecting against skin cancer and rosacea."

http://rosacea-support.org/melanocorp-gets-warning-from-fda-for-melanotan-ii.html

3. an interview with Ann-Marie Lindstrom, The Rosacea Handbook

Here is the first in what I hope will be a series of interviews with a few rosacea writers that are mostly unknown to the online rosacea community.

Thanks to Ann-Marie Lindstrom for agreeing to answer some questions from Rosacea News.

http://rosacea-support.org/an-interview-with-ann-marie-lindstrom-the-rosacea-handbook.html

4. maximum effective dose of doxycycline is 40mg a day

There has been a lot of copy written about so-called low dose or anti-inflammatory dose doxycycline. This form of antibiotic therapy is one of the more promising recent therapeutic developments ; it will likely become a widely known and available treatment.

http://rosacea-support.org/maximum-effective-dose-of-doxycycline-is-40mg-a-day.html

5. Rosa Relief Face Cream offering free samples

Gary Hammerstrom from Bio-Application Technologies is offering a free sample of a new product his company has developed. His offer has been posted to the RSG as Free sample offer of a new product named Rosa Relief Face Cream.

http://rosacea-support.org/rosa-relief-face-cream-offering-free-samples.html

6. Long Pulse Dye Laser and Nd:YAG (Cynergy Multiplex) used together

This just published paper is a case report of one 60 year-old patient who was unresponsive to the usual first line rosacea treatments. Additionally 2 treatments with Lumens One IPL were unable to offer clearance.

http://rosacea-support.org/long-pulse-dye-laser-and-ndyag-cynergy-multiplex-used-together.html

7. new rosacea support forum: how to post

The new Rosacea Support Forum is up and running. This forum is one the companion forum to the email based Rosacea Support Yahoo!Group.

The new forum is fast, friendly and fun !

http://rosacea-support.org/new-rosacea-support-forum-how-to-post.html

8. an interview with Arlen Brownstein, Rosacea, Your Self-Help Guide

Thanks to Arlen Brownstein  for answering some questions from Rosacea News.

http://rosacea-support.org/an-interview-with-arlen-brownstein-rosacea-your-self-help-guide.html

9. arnica montana for swelling and bruising

In a recent Rosacea News article the highlighted LPDL treatment regime used Arnica pre- and post- treatment to reduce the bruising and swelling associated with pulse dye laser.

http://rosacea-support.org/arnica-montana-for-swelling-and-bruising.html

10. an interview with Georgie Holbrook, Joy-Full Holistic Remedies

Thanks to Georgie Holbrook for answering some questions for Rosacea News

http://rosacea-support.org/an-interview-with-georgie-holbrook-joy-full-holistic-remedies.html

11. topical kinetin (kinerase) moisturizer for anti-aging

This article was first highlighted by Rosacea News in March 2006 as result of the 2006 Annual Meeting of the AAD, Poster Session in San Francisco. The paper was called Tolerability and efficacy of a moisturizing lotion containing 0.1% kinetin for improving the signs of acne rosacea in facial and neck skin

http://rosacea-support.org/topical-kinetin-kinerase-moisturizer-for-anti-aging.html

12. incyclinide fails for rosacea, acne still possible

Despite promising looking Phase 1 and initial Phase 2 dose finding studies, Incyclinide will no longer be developed as a treatment for rosacea.

http://rosacea-support.org/incyclinide-fails-for-rosacea-acne-still-possible.html

Monday, September 03, 2007

Rosacea News August 2007

Rosacea News August 2007 - http://rosacea-support.org/2007/08

1. Cathelicidins make the news

Lots of buzz at the moment about the publicity raised by a nature.com article about Cathelicidins.

This article is a result of a few years of research by Dr. Gallo. We’ve been reading about this research, some of it sponsored by the NRS, since at least the Fall of 2002

2. sanrosa (COL-118) phase 2 looking promising

As was mentioned in January this year, COL-118 (product code used for the sansrosa product) is expected to move from Phase 1 to Phase 2 in 2007. Collagenex has published results from their Phase 2 trials that were conducted in order to test some dosage levels to assess how they effective they are and also any side effects.

3. Rosacea News is changing

As I approach 300 articles for Rosacea News, it is time for a bit of a change. I started writing items in July 2005, and back then I wasn’t really sure what I’d find. Since then I’ve learnt heaps as I trolled the internet looking for fresh and interesting developments in the world of rosacea. Surprisingly, there is a lot of good information out there.

4. Most popular Resource & Supplements Items

Dan has done a great job in creating and maintaining the Rosacea Supplements & Resources Pages. I’ve just checked the server stats and here are links to the most popular pages.

5. how to cure a red face (facial erythema or redness)

Many rosacea sufferers are looking for help to reduce the redness of their face. This is one of the first rosacea symptoms that people might notice. What treatments have fellow rosacea sufferers used to hide the ruddiness and angry face that sometimes accompanies rosacea ?

6. RR: Summer 2007 Roundup, demodex bacteria

The NRS have published their Summer 2007 edition of Rosacea Review. They highlight a paper presented at this year’s AAD Meeting in Washington DC.

Thursday, August 30, 2007

Rosacea News July 2007

Rosacea News July 2007

view all the July News Items online: http://rosacea-support.org/2007/07

1. oracea plus metrogel, better than 100mg doxycycline plus metrogel ?

A clinical trial, sponsored by CollaGenex, is recruiting patients to see how Oracea compares to doxycycline (100mg once a day) when combined with metrogel 1%.

We can see from a Collagenex annual report that COL-101 was the name for Periostat MR, which then became Oracea.

oracea plus metrogel, better than 100mg doxycycline plus metrogel ?

2. organic tomatoes higher in quercetin and kaempferol

In a 10 year study highlighted by the BBC, organic tomatoes were found to contain twice the levels of flavonoids compared with commonly grown tomatoes.

organic tomatoes higher in quercetin and kaempferol

3. Melanotan causing vision problems ?

An interesting thread over at the Rosacea Forum to do with the safety of taking melanotan. Steve, who is using Melanotan himself, points to a thread on a Melanotan message board where Robert is reporting some issues with gradual onset vision problems ;

Melanotan causing vision problems ?

4. VEGF and macular degeneration any link to rosacea ?

It is not only rosacea that is interested in how VEGF affects blood vessels and thus how a disease that is related to blood vessels progresses. The `wet` type of macular degeneration is associated with the growth of abnormal blood vessels. Thus there may well be some common areas of research between rosacea and macular degeneration

VEGF and macular degeneration any link to rosacea ?

5. Daily Telegraph: seeing red, how to combat rosacea

It is nice to see that slowly newspaper articles on rosacea are becoming more informed. One might even think that they are surfing the net to see what new information is out there.

Daily Telegraph: seeing red, how to combat rosacea
_________________

Thursday, July 12, 2007

Rosacea Support and News Pages on the move

The Rosacea Support Group and Rosacea News pages are moving to a new site. Yes that's right, after quite a few years at rosacea.ii.net they are on the move to a new wordpress inspired site at rosacea-support.org ;

Now with the ability to leave a comment on every page and a great search feature and posts all nicely categorised.

Coming soon a new forum as well.

If you are an internet wizard and use a feed reader, you can just click here ;

Enjoy !

Friday, July 06, 2007

Rosacea News June 2007

1. Trial recruiting for Pulse Dye Laser with Photodynamic Therapy

TRIAL: The Bispebjerg Hospital in Copenhagen is currently recruiting patients for a study comparing  the "efficacy and adverse effect from long-pulsed dye laser versus long-pulsed dye laser-mediated photodynamic therapy for acne vulgaris and rosacea." The study is titled Laser-Mediated Photodynamic Therapy of Acne Vulgaris and Rosacea

http://rosacea.ii.net/news/2007/06/trial-recruiting-for-pulse-dye-laser.html

2. cetaphil moisturizing cream helps rosacea dry skin

PAPER: This study is saying that a gentle moisturizer is an important part of a rosacea beating regime. This was one of the gems that took me years to realize. In order to best treat rosacea, you will need to find a good gentle skin care routine. This routine should include a cleanser, moisturizer and sunscreen. Any prescription or over the counter topicals can then be added to your gentle care regime.

Beneficial use of Cetaphil(R) Moisturizing Cream as part of a daily skin care regimen for individuals with rosacea. J Dermatolog Treat.  2007;18(3):158-62., Laquieze S, Czernielewski J, Baltas E. , PERITESCO. Paris. France.

http://rosacea.ii.net/news/2007/06/cetaphil-moisturizing-cream-helps.html

3. anxiety, depression and being obsessed with your skin

NEWSPAPER: From: This is London, from the Evening Standard: Train suicide of woman depressed by her wrinkles

What a terribly sad story. Rosacea can be an all consuming disease and there is definitely a danger in becoming obsessed with your skin. The struggle to look normal can be too much for some, sadly. Please everyone realize that other people really aren't as interested or worried about your skin as you are. If you feel you aren't coping with your anxiety or feelings about yourself then please be brave enough to see a doctor and ask for some help.

http://rosacea.ii.net/news/2007/06/anxiety-depression-and-being-obsessed.html

4. WP: Fashion & Beauty Article: Seeing Red

NEWSPAPER: It is not very often than an online newspaper or news site features a half decent article about rosacea. This article from the Fashion & Beauty section of the Washington Post is reasonable for a mass audience paper. Rosacea is still a mystery to the population at large, so it is encouraging to see this sort of article. 

http://rosacea.ii.net/news/2007/06/wp-fashion-beauty-article-seeing-red.html

5. metrogel: how it gets into your skin

PAPER: Two recently published papers look at the processes involved when you apply metrogel topically. The first abstract just tells us that they undertook some new ways of measuring metronidazole absorption, but doesn't reveal their results.

The second abstract suggests that a cream based metronidazole formulation (presumably metrocream, but could also include Noritate) had the greatest absorption when tested with human skin. They suggest that future research is needed to determine if indeed this makes any difference to rosacea symptoms.

http://rosacea.ii.net/news/2007/06/metrogel-how-it-gets-into-your-skin.html

6. demodex mite bacteria causes the inflammation ?

PAPER: This paper is proposing that a particular type of bacteria taken from a demodex mite, called Bacillus oleronius is capable of producing an inflammatory response. As the mite was isolated from a patient with papulopustular rosacea the tempting conclusion is that this bacteria has caused these rosacea symptoms. This part is of course not confirmed, just the fact that it is possible to isolate a bacteria that causes an inflammatory response in humans.

http://rosacea.ii.net/news/2007/06/demodex-mite-bacteria-causes.html

Monday, June 04, 2007

Rosacea News May 2007

1. RRF funded study: cathelicidins and VEGF reduced by IPL/PDL

The NRS has published on their blog some results from a recently
concluded study. The study was titled `Structural and biologic changes in the rosacea skin induced by pulse dye laser and intense pulsed light', and was part funded by the now defunct Rosacea Research Foundation.

http://rosacea.ii.net/news/2007/05/rrf-funded-study-cathelicidins-and-vegf.html

2. wearing contact lenses and ocular rosacea

Many rosacea sufferers, especially those who suffer from ocular rosacea wonder if they will ever be able to regularly and comfortably wear contact lenses. When your eyes are sore, gritty and blurry would one want to consider trying to apply a contact lens ? I don't have any
ocular symptoms but I do know that I take it as right to be able to
wear contacts instead of the hassle of glasses.

PAPER: In this article, Contact Lens Wear in The Rosacea Patient (which was mentioned in a recent edition of Rosacea Review), Dr. Mannis lists the factors involved with the successful wearing of contact lenses when you suffer from ocular symptoms.

http://rosacea.ii.net/news/2007/05/wearing-contact-lenses-and-ocular.html

3. melanotan: could it cause skin cancer ?

This article from the DailyMail is offering some warnings about being
too quick to jump on the Melanotan II bandwagon. It is worth
remembering on top of all of the warnings below, that Melanotan
specifically as a rosacea treatment is also something we know very
little about. I think that the combination of rosacea sufferers
desperate for relief, the relative ease of obtaining Melanotan, and the fact that so little is known about its effects, is a recipe for
dangerous outcomes.

NEWS PAPER: Pretty pills: The dark side of the latest underground
beauty trend

http://rosacea.ii.net/news/2007/05/melanotan-could-it-cause-skin-cancer.html

4. elidel vs. protopic, does it work for rosacea bumps ?

This recently published blind study suggests that elidel (pimecrolimus)
is no better for rosacea papules and pustules than the vehicle it uses.

A previous study in 2005, Pimecrolimus for treatment of acne rosacea
suggested that elidel could indeed be useful for rosacea, but this
study was not a double blind study - it was not compared to another
inactive topical.

PAPER: Pimecrolimus cream 1% for papulopustular rosacea: a randomized vehicle-controlled double-blind trial.

http://rosacea.ii.net/news/2007/05/elidel-vs-protopic-does-it-work-for.html

5. incyclinide dosage trials: 40mg too much

Collagenex has announced that their ongoing trials to find the best
dosage for Incyclinide have discovered that 40mg can cause
photo-toxicity.

PRESS RELEASE: CollaGenex Pharmaceuticals Discontinues 40 mg Cohort of Phase II Dose-Finding Study of Incyclinide for the Treatment of Acne

http://rosacea.ii.net/news/2007/05/incyclinide-dosage-trials-40mg-too-much.html

Wednesday, May 02, 2007

Rosacea News April 2007

1. Chlamydia pneumoniae (Cpn) and azithromycin
PAPER: The role of Chlamydia pneumoniae in the etiology of acne rosacea: response to the use of oral azithromycin.

As a followup to the recent note pathogen infection (Chlamydia pneumoniae) cause theory, comes a recently published paper, the first to address Cpn and Rosacea. This paper is very preliminary, but at least now Cpn is on the map.

http://rosacea.ii.net/news/2007/04/chlamydia-pneumoniae-cpn-and.html

2. Pyratine 6 (vs. Kinetin) reduces redness and acne lesions

WEB Site: The internet Press Release sites are full of an announcemet from Senetek about a product called Pyratine 6 and its possible use in treating rosacea. The announcement is based on a comparison of Pyratine 6 with another of Senetek's products - Kinetin.

http://rosacea.ii.net/news/2007/04/pyratine-6-vs-kinetin-reduces-redness.html

3. IPL excellent for treating red face and broken blood vessels

This 2007 paper confirms another study which was published in the same journal in 2003.

PAPER: Objective Evaluation of the Effect of Intense Pulsed Light on Rosacea and Solar Lentigines by Spectrophotometric Analysis of Skin Color.

http://rosacea.ii.net/news/2007/04/ipl-excellent-for-treating-red-face-and.html

4. anti-flammatory actions of tetracyclines

This article, just published is adding to body of research of the anti-inflammatory actions of the tetracycline family.

PAPER: Anti-Inflammatory Activity of Tetracyclines

http://rosacea.ii.net/news/2007/04/anti-flammatory-actions-of.html

5. oxytetracycline (Terramycin) joins low dose antibiotics

This paper (sadly only available in Polish) highlights the fact that one more tetracycline - oxytetracycline is joining the ranks of proven low dose antibiotics. A normal dose of oxytetracycline is 250-500mg four times a day.

PAPER: Oxytetracycline--mechanism of action and application in skin diseases

http://rosacea.ii.net/news/2007/04/oxytetracycline-terramycin-joins-low.html

6. cutanix goes offline, gets letter from FDA

A few people have noticed that Cutanix seems to have vanished off the face of the internet. Their web sites at cutanix.com, tvdepot.com are offline, and their corporate web site at bioformmedical.com no longer even mentions Cutanix.

http://rosacea.ii.net/news/2007/04/cutanix-goes-offline-gets-letter-from.html

7. flavay anthogenol hydrates and reduces skin stress

I thought this product sounded interesting, especially as it is professionally promoted, readily available, but little is known about how well it works for rosacea stressed skin. Anything that has been proven to reduce oxidative stress and help hydration could also help in rosacea.

http://rosacea.ii.net/news/2007/04/flavay-anthogenol-hydrates-and-reduces.html

Monday, April 30, 2007

flavay anthogenol hydrates and reduces skin stress

I thought this product sounded interesting, especially as it is professionally promoted, readily available, but little is known about how well it works for rosacea stressed skin. Anything that has been proven to reduce oxidative stress and help hydration could also help in rosacea. Some of the other claims like ;

"In addition to being a potent antioxidant, ANTHOGENOL is best known for the nutritional support it gives to the vascular system, especially to the thin and delicate capillaries where all the system’s essential functions culminate."

[Proven Health Benefits for Circulatory System]

also sound interesting.

Only time and user feedback will tell how well this supplement works. If you do try Anthogenol please post over at rosacea-support and let us know how you get on.

Anthogenol is made from pine bark and grape seed extract ;

Dr. Masquelier received several patents for the commercial extraction and isolation of OPCs from pine bark and grape seeds. It is these highly defined complexes that have been subject to intensive biological, toxicological, pharmacological and analytical research; and approved in Europe as over-the-counter medicines.

[Masquelier on OPCs and grape seed extracts and pine bark extracts]

The web sites are professional looking so the company is investing in the promotion of this product.

One relevant looking study is below ;

Anti-Inflammatory and Skin-Hydrating Properties of a Dietary Supplement and Topical Formulations Containing Oligomeric Proanthocyanidins, B. Hughes-Formella, O. Wunderlich, R. Williams, Bioskin GmbH, Hamburg, Germany. Skin Pharmacology and Physiology 2007;20:43-49

Background: Anti-inflammatory and skin hydration properties of a dietary supplement and 2 topical formulations (Anthogenol) with oligomeric proanthocyanidins were investigated.

Methods: Forty-two subjects were randomized into 2 groups: one taking the dietary supplement (100 mg/day) and the other without supplement. After 4 weeks, erythema was induced using UV radiation followed by treatment with topical cream or lotion. Erythema was measured for up to 72 h after irradiation. Skin hydration after 1 and 2 weeks of application of the cream and lotion was also measured in separate test fields.

Results: Both topical formulations led to a significant suppression of erythema formation and the dietary supplement led to an additional slightly stronger suppression. Thus 72 h after UV exposure and compared to the control fields of patients that had not taken a dietary supplement, erythema was slightly (13.2%) lower in the subjects that had taken a dietary supplement. The cream resulted in a maximal reduction of erythema of 45.9% (p = 0.0015), while the lotion resulted in a maximal reduction of 53.1% (p = 0.0002). Both topical formulations also increased skin hydration (by nearly 20%; p < 0.002 for all combinations of dietary supplementation and topical treatment) and the hydration was higher in the group taking the dietary supplement.

Conclusion: The regular use of Anthogenol products may help to protect from free-radical-mediated skin inflammation and to increase skin hydration.

Further Reading ;

Monday, April 09, 2007

ocular demodex, tea tree oil as a treatment

ocular demodex, tea tree oil as a treatment

This recently published paper suggests that a variety of ocular symptoms might be caused by demodex infestation. Six patients all having demodex present, and suffering with recalcitrant symptoms (including 4 diagnosed with rosacea) were given tea tree oil for a weekly eyelid scrub and tea tree shampoo for a daily scrub. All patients showed a large decrease in demodex counts and relief from their symptoms. Other recently published studies are showing that tea tree oil kills demodex.

Eucerin Redness Relief: product reviews

Eucerin Redness Relief: product reviews In 2005 a new range of skin care products from Eucerin (Beiersdorf Inc) called Eucerin Redness Relief was released. They are claimed as "Safe for sensitive skin and appropriate for Rosacea".

aveeno ultra calming with feverfew: product reviews

aveeno ultra calming with feverfew: product reviews There is a lot of interest from rosacea sufferers in treating their rosacea with natural or herbal therapies and remedies. Many shy away from treatments like antibiotics and metrogel. So far the best collection of information about natural products I've found is a paper called Treatment of Rosacea with Herbal Ingredients. One of the herbs mentioned in that paper was Feverfew.

Sunday, April 01, 2007

Rosacea News March 2007

Rosacea News March 2007

1. Xolegel for treating seborrheic dermatitis (seb derm)

PAPER: Anti-inflammatory effects of ketoconazole: Clinical benefits in
the treatment of seborrheic dermatitis

http://rosacea.ii.net/news/2007/03/xolegel-for-treating-seborrheic.html

2. wanted: 11-18 year olds for survey about online support

SURVEY: Fiona Fox, who is a PhD student at The Centre for Appearance
Research, University of the West of England, Bristol, UK, is looking
for young people with a skin condition to take part in some research
online.

http://rosacea.ii.net/news/2007/03/wanted-11-18-year-olds-for-survey-about.html

3. ocular rosacea difficult to cope with

PAPER: Quality of life impact of ocular rosacea,

http://rosacea.ii.net/news/2007/03/ocular-rosacea-difficult-to-cope-with.html

4. aveeno ultra calming with feverfew: product reviews

REVIEWS: Aveeno has released 3 products from their `Active Naturals
Feverfew' range ; Ultra-Calming Daily Moisturizer with SPF 15,
Ultra-Calming Moisturizing Cream and Ultra-Calming Foaming Cleanser.

http://rosacea.ii.net/news/2007/03/aveeno-ultra-calming-with-feverfew.html

5. lavender, arnica, aloe vera, tea tree oil, and calendula ; do they work ?

MAGAZINE: Natural first aid: Are natural first-aid remedies effective?'

http://rosacea.ii.net/news/2007/03/lavender-arnica-aloe-vera-tea-tree-oil.html

6. pathogen infection (Chlamydia pneumoniae) cause theory

COMMENTS: A really interesting thread is going on in the
rosacea-support group. Dan is airing some of his thoughts on how a
pathogen might lead to the chronic inflammation we see in rosacea.

http://rosacea.ii.net/news/2007/03/pathogen-infection-chlamydia-pneumoniae.html

7. so just how does metrogel work ?

COMMENTS: Actually the way that metronidazole works is well known. How
the effect of metrogel leads to a benefit in rosacea, well, that is
something worth exploring some more later on.

http://rosacea.ii.net/news/2007/03/so-just-how-does-metrogel-work.html

8. exotic and expensive cosmetics, do they work ?
WEB SITE: Golf for Women: First Annual Skin Care Awards.

http://rosacea.ii.net/news/2007/03/exotic-and-expensive-cosmetics-do-they.html

9. ocular demodex, tea tree oil as a treatment

PAPER: Corneal Manifestations of Ocular Demodex Infestation
PAPER: Clinical treatment of ocular demodecosis by lid scrub with tea
tree oil
PAPER: In vitro and in vivo killing of ocular Demodex by tea tree oil.

http://rosacea.ii.net/news/2007/03/ocular-demodex-tea-tree-oil-as.html