Acne Rosacea

Rosacea News December 2011

2012-01-04T05:02:00.001-08:00

1. UV Exposure leads to Oxidative Stress

As researchers try to further describe exactly what is going on in rosacea, more tiny bits of information arise. Here, this abstract is telling us that; Ferritin positive cells are much more prevalent in rosacea sufferers Severe rosacea sufferers have significantly more ferritin positive cells Blood peroxide levels are higher in rosacea sufferers …

2. CD5024 Cream in Phase 3 Trials (Metrocream 1% ?)

Galderma has another rosacea-targeted treatment, until now undisclosed, in the final stages of approval. Hey – how come no one told me?

Could it be possible that the rosacea heavyweight Galderma has kept a new product so secret?
What is this CD5024?
Just what exactly is this CD5024 1% Cream? Galderma …

3. “Glaucoma Gel” Good for Redness: Daily Mail

The Daily Mail continues its interest in rosacea treatments with an article about an unnamed glaucoma treatment that has been formulated as a gel treatment for the redness of rosacea. Of course we know this treatment as Sansrosa. Other names we have seen over the years include COL-118 and CD07805/47. The active ingredient in the glaucoma treatment of mentioned …

4. Ocular Rosacea Video Worth a Watch

Thanks to a tip from Dori, on the Rosacea Support Group Email Group, here is a link to a video of a lecture giving a good overview of ocular rosacea and treatments.
Ocular Rosacea: Curse of the Celts and Celeb…

5. Finacea matches the pH of Skin so Penetrates Well

We know that the pH of skin is around 5.4. The makers of Finacea, Intendis have formulated Finacea to be pH of 4.8, which means that Finacea is reasonably close to the same pH as skin. One of …

6. IPL London Spa Burn Victim Awarded Tens of Thousands in Damages

In 2008 we heard about Charlotte Cripps, a writer for the The Independent was badly burned by an IPL treatment at a London Spa. Today we …

7. Treating Intestinal Bacteria with Xifaxan May Improve Rosacea

Some more recent publicity from Internal Medicine News on the possible link between Small Intestinal Bacteria Overgrowth (SIBO) and Rosacea. In 2008 Rosacea News highlighted a paper that suggested that treating patients with rosacea and SIBO with Rifaximin would improve both their SIBO and rosacea symptoms. That posting has attracted a lot of interest, heading towards 100 comments. Two threads …

8. Finacea Foam Trials Results Look Good

Some recent trial results confirm that Intendis are moving forward with the development of Finacea Foam. The summary of a recent trial, quoted in Skin and Allergy News shows that Finacea Foam is more effective at reducing rosacea symptoms compared to the inactive vehicle. This trial doesn’t show whether Finacea Foam is more effective than Finacea Gel, but does suggest that Finacea Foam likely to …

Rosacea News December 2011

2012-01-04T05:00:00.001-08:00

1. UV Exposure leads to Oxidative Stress

2. CD5024 Cream in Phase 3 Trials (Metrocream 1% ?)

Galderma has another rosacea-targeted treatment, until now undisclosed, in the final stages of approval. Hey – how come no one told me?

Could it be possible that the rosacea heavyweight Galderma has kept a new product so secret?
What is this CD5024?
Just what exactly is this CD5024 1% Cream? Galderma …

3. “Glaucoma Gel” Good for Redness: Daily Mail

4. Ocular Rosacea Video Worth a Watch

5. Finacea matches the pH of Skin so Penetrates Well

We know that the pH of skin is around 5.4. The makers of Finacea, Intendis have formulated Finacea to be pH of 4.8, which means that Finacea is reasonably close to the same pH as skin. One of …

6. IPL London Spa Burn Victim Awarded Tens of Thousands in Damages

In 2008 we heard about Charlotte Cripps, a writer for the The Independent was badly burned by an IPL treatment at a London Spa. Today we …

7. Treating Intestinal Bacteria with Xifaxan May Improve Rosacea

December 6th, 2011, by David Pascoe | diet, rosacea cause | Edit

8. Finacea Foam Trials Results Look Good

Rosacea News October 2011

2012-01-02T06:51:00.001-08:00

Better late than never …

1. Demodex Infestation: the Missing Link ?

Firmly in the pure speculation category is a recent paper that proposes that pityriasis folliculorum (or demodex mite infestation) is the missing link in our understanding of rosacea. Plainly put, Dr. Forton, a dermatologist from Belgium, suggests that rosacea is a …

2. NRS highlights Neurologic form of Rosacea

The NRS Blog today mentions the recent publications that raise a possible new Subset of Rosacea. Even though this is just a passing reference, it is good to see that the NRS …

3. Elorac Patenting Oral Niacinamide + Oral Azelaic Acid (Finacea)

An unusual patent has surfaced that is suggesting the oral use of azelaic acid. Azelaic Acid is better known as the active ingredient in the topical finacea. This patent suggests an oral treatment that combines niacinamide with azelaic acid. The owner of the patent, Elorac is known from their recent trials of Carbamide Peroxide as a rosacea treatment. Finacea has received some …

4. Sansrosa not Susceptible to Tolerance or Rebound

Some news today from the Phase 2B Sansrosa Trials;

Galderma is now confirming that during the 8 week trial, participants did not suffer from tachyphylaxis or rebound.

This means that if you stop and start sanrosa or continue to use it for an extended period you likely won’t suffer from a rebound effect or from a reduced effectiveness.

This is some good news as it indicates the formulation …

5. Merck Trialling Laropiprant for the Redness of Rosacea

A product from Merck designated as MK-0524, also known as Laropiprant, is to be trialled as a treatment for the redness of rosacea. This is great news for rosacea …

6. Get ready for MetroFoam

A recently updated patent application by Galderma shows that they want to reserve the right to create a Metronidazole Foam product.

Galderma has a long history with topical metronidazole products, starting with Metrogel 0.75%, then adding Metrolotion and Metrocream, and when the patent on the 0.7% Metrogel expired, Galderma created Metrogel 1%.

Past research seems to suggest that it matters little whether you use Metrogel, Metrolotion, …

7. Niacin Flushes More when we are Worried About What Others Think

Continuing his research in facial flushing and anxiety, Dr. Peter Drummond from Murdoch University has published some new research on social anxiety and facial flushing.

The trial found that Niacin, which is known to induce a facial flush, actually causes more flushing in people that worry about what others think of them.

By blinding participants to whether they were given Niacin or placebo, and measuring facial blood …

8. Powell: Randomized Clinical Trials are not the whole story

Writing in the British Journal of Dermatology, the well known Rosacea Researcher Professor Frank Powell says that research based on randomized clinical trials are not the be-all and end-all for rosacea research. He tells us that there is still room for other sorts of innovation, especially when seeking treatments from your dermatologist. Recently a Cochrane review of 58 clinical trials told us that …

9. Obagi Rosaclear may be better than Metrogel 0.75% + Standard Skincare

Another published abstract that appears to be building the case for the Rosaclear Integrated Rosacea Treatment from Obagi. Although the article …

10. News Shorts: Internet Anxiety, Food Hospital

Some quick links to items from around the web. 1. Internet Searching leads to greater anxiety for melanoma sufferers Of course everyone is now using the internet to read up on everything health related. You may be headed for some unnecessary anxiety though, so be careful. Internet Use and Anxiety in People with Melanoma and Nonmelanoma Skin Cancer …

Rosacea News November 2011

2011-12-13T18:15:00.001-08:00

1. FDA Approved 35 New Drugs in FY 2011

The FDA announced today that the U.S. Food and Drug Administration approved 35 new medicines in fiscal year 2011. They included “important advances for patients, including: two new treatments for hepatitis C; a drug for late-stage prostate cancer; …

2. Topical Ivermectin + Metrogel from Galderma

An update to the 2009 filing of the patent covering preparations of Ivermectin and Metronidazole has emerged at the USPTO Patent Application Site. That application was in turn a followup to the original French language application 0505918 from 2005. The patent covers many different combinations of ivermectin and metronidazole such as emulsion, cream, gel with ivermectin present in an amount of from 0.01% to …

3. Amneal Pharmaceuticals joins the Generic Oracea War

News today of yet another company in the courts fighting against Galderma for the right to make Generic Oracea. Amneal Pharmaceuticals, based in Gujarat, India, a producer of generic …

4. Pineapple + Cottage Cheese, Get Bromelain from your fridge

Are you searching for a natural therapy to quickly relieve your symptoms? Would you be willing to try freshly crushed pineapple and cottage cheese on your face? Ellen …

5. Scenesse One Step Closer for Erythropoietic Protoporphyria (EPP)

News from Clinuvel that Scenesse (their implant of afamelanotide 16mg) has shown a provable positive effect on EPP sufferers in a US Phase 2 Trial. EPP is an acute intolerance to exposure to sunlight and UV. Sufferers of …

6. Accutane Gaining More Popularity

A new paper that highlights the progress made in recent years by researchers who are seeking to prove that accutane is a viable rosacea treatment.

This growing body of proof is actually quite important because oral isotretinoin is not officially approved as a treatment for rosacea. Doctors can prescribe accutane off-label for use in rosacea, so more comprehensive trials of accutane can only be a good thing. Further, the growing difficulty in finding a doctor who will actually prescribe accutane means that rosacea sufferers need all the proof that they can get their hands on.

Rosacea News September 2011

2011-10-04T22:27:00.001-07:00

1. Sanofi-Pasteur to make an Acne Vaccine

A vaccine for acne ? Well it appears that one may actually become a reality. A recent article in the New Scientists explains how targeting a protein called CAMP can …

2. Galderma wanting to show Oracea Maintains Rosacea Remission

A recently posted proposed Clinical Trial has me thinking that Galderma wants to be able to market Oracea as a product to Maintain Rosacea Remission. First Some History …

3. Placebos Get Better Over Time: The Weird World of Placebos

More from the weird and wonderful world of clinical trials and the mysterious Placebo Effect. We know that somehow even dummy pills can kick-start the body’s recovery engine. This latest article from WIRED tells us that drug …

4. Diet and Acne: What the Latest Research Says

September 16th, 2011, by David Pascoe | acne treatments, diet | Edit

Over at the Acne Blog, Daniel Kern has posted a few high level posts relating to recent readings he has undertaken on the topic of diet and acne. Daniel …

5. Oracea set to generate $260m in 2011

An interesting note from the detailed interim judgement in the ongoing patent dispute between Galderma and Mylan. As part of the proceedings Mylan looked at the on-going Oracea sales and projected that Galderma can expect to receive around $260 million in 2011. MYLAN PHARMACEUTICALS INC., v. GALDERMA LABORATORIES, L.P.; et. al. …

Rosacea News August 2011

2011-09-26T21:37:00.001-07:00

1. Melanin also Protects You from Radiation !

Startling news today from the Clinuvel Blog: Melanin also has the ability to protect from radioactive emissions like X-rays and Gamma-rays. How interesting that the chemical that …

2. Mylan Violates The Chang Patent for Oracea

Another step in the ongoing battle between Galderma and Mylan over the right to manufacture generic Oracea. A judge has declared that Mylan infringes 1 of the patents that protects Oracea from generic copies. Some History …

3. How Much Sunscreen Should I Use?

Another fabulous data visualisation from Information is Beautiful. This time David McCandless tackles the thorny issue of How Much Suncreen Should I Wear ? The Sunscreen Smokescreen July 11, 2011 It started with a question. It always does. This time, the question was simple: How much sunscreen should I wear? I’m …

4. NRS Funds New Rosacea Studies for 2011

In the Summer 2011 Rosacea Review, The National Rosacea Society announced that they are funding 3 studies in new areas of rosacea research. This is great news; not only is the NRS continuing to fund 5 existing studies, it is funding …

5. NRS Continues Leading Edge Research Funding

The National Rosacea Society recently announced that they will be continuing to fund 5 existing rosacea research streams. Confirming their faith in the on-going NRS sponsored research, the NRS has announced additional funding to the following researchers. 1. Dr. …

6. Lupin and Medicis Agree Over Generic Solodyn

In contrast to the ongoing disputes over generic Oracea, the makers of the low-dose minocycline Solodyn, Medicis have entered into a joint development and sales agreement with Lupin Pharmaceuticals.

Solodyn is a form of Minocycline, a member of the tetracycline famaily, available in 8 strengths, prescribed based primarily on your weight.

7. Low Dose Accutane from St Thomas’ Hospital in London: Daily Mail

The Daily Mail has another of its semi-regular stories on Rosacea today. This time the article highlights the use of low dose accutane to treat hyper keratinisation, slow down sebum production, and also serve as an anti-inflammatory and anti-bacterial agent.

Rosacea News July 2011

2011-09-26T21:27:00.001-07:00

1. Visualising Evidence for Oral Supplements: Snake Oil All Round

Below is a wonderfully rich graphic that tries to help visualise the available evidence for the efficacy of dozens of oral supplements. The aim of the creators is to visualise tangible health benefits when taken orally by an adult with a healthy diet. Only human, randomised placebo-controlled trials were used to create this graphic. Information is Beautiful: Snake Oil? …

2. Gallo to trial Aminocaproic Acid as Cathelicidin Inhibitor

Just posted are some details of a new trial rising out of the work of Dr. Richard Gallo’s group at the University of California, San Diego. Gallo is well known for his work on the relationship between antimicrobial peptides such as cathelicidin, and rosacea. The trial will compare topical 25% aminocaproic acid (ACA) mixed with Vanicream vs Vanicream on its own. The …

3. Allergan buying Vicept Therapeutics to get V-101 / Oxymetazoline

News today that Allergan are buying the privately held pharmaceutical company Vicept Therapuetics. The aim of many small startup companies is to be acquired by a larger company, Vicept telling us that “We believe Allergan …

4. Rosacea Cure eBooks: All Just SPAM?

There is a seedy dark side to the internet. OK you knew that already, but perhaps there are forces at play on the internet that are more subtle than you realise. Lets turn our focus toward the emergence of the “Rosacea Cure eBook” Phenomenon. Over the last few years there are more and more web sites that exist to solely sell you …

5. Metrogel, Finacea and Oracea are Best for Rosacea

A systematic review of the available rosacea research confirms that Metrogel, Finacea and Oracea are effective for moderate to severe rosacea. One study further found cyclosporine 0.05% ophthalmic emulsion effective for ocular rosacea. This review looked at the published results of 58 trials to note bias and construct a high level summary of the results. No Surprises Here It will come as …

6. Cosmetics and Makeup work fine applied after Metrogel

This research comes up with the finding that using a foundation after applying Metrogel 1% won’t worsen rosacea symptoms. Most of the participants in the trial were happy with the appearance of foundation, when used in combination with Metrogel.

The authors tell us that there is little research into whether makeup both makes rosacea worse or whether those who suffer from rosacea can also successfully use makeup like foundation.

Rosacea News June 2011

2011-08-12T01:19:00.001-07:00

1. 9 New Drugs in Development for Rosacea

The Pharmaceutical Research and Manufacturers of America tells us that there are currently 9 drugs in development for rosacea. I was initially curious as to how counted nine. Read on if you want to see how they get to this number. 277 Medicines in Development For Skin Diseases Washington, D.C. (June 13, 2011) — America’s biopharmaceutical …

2. Why Do New Drugs take SO LONG to be Developed?

For everyone waiting on the latest and greatest new treatment for rosacea, new drugs seem to take forever to make it to the market. Taking a step back and looking at new drug development in general, it is very sobering to read how few drugs actually make it to an approved product; THE DRUG DISCOVERY , DEVELOPMENT AND …

3. Final FDA Approval of Sansrosa, expect 15 months post Phase III

A popular topic online at the various rosacea forums is to guess when Sansrosa will become available. So far all guesses have proved way way too optimistic. Given that we believe that the process is in the later stages of Phase III, what sort of best outcome possible, educated guess might be worth offering up? Once the Phase III process completes (which itself …

4. Riversol: From idea to a Rosacea Product

I thought this article from the Vancouver Sun was quite interesting from the point of view of developing new products for rosacea sufferers. Just how do you get from something that you think might work, to a product …

5. Galderma blocking Impax making Generic Oracea

The last we heard from Impax Laboratories was in late 2009 when they had filed an Abbreviated New Drug Application (ANDA 91-447) to produce a generic version of Oracea. …

6. Inactive Ingredients Just as Important as Active Ingredients

Rosacea sufferers get good at looking through ingredient listings. What magical ingredient has been included in this product that might help me? But you should keep reading and take notice of everything listed.

7. How do you cope with Rosacea at Work?

The NRS recently highlighted the possible negative effects of rosacea in the workplace and on their career.

As well any physical symptoms such as facial burning, blurred vision and debilitating flushing, the secondary worries about what others will think about your appearance make it tough for rosacea sufferers at work.

Rosacea News May 2011

2011-06-16T05:19:00.001-07:00

1. Custom Cleanser and Moisturizer from acne.org

The owner of the site acne.org, Daniel Kern has created an acne treatment regime that is cheap and simple. It looks to me like any benefits to rosacea sufferers are yet to be discovered. acne.org is a large online community of acne suffers that includes a small area for rosacea sufferers. The site is run mostly by volunteers and doesn’t accept any …

2. Most Patients use Steroids for Trivial Problems

Steroid Induced Rosacea is, sadly, one hot topic.

I know this because the blog posting Treating Steroid Induced Rosacea is one of the most visited pages on this site, and is currently approaching 1000 comments. Unfortunately many …

3. Sansrosa Parallel Phase III Safety and Efficacy Trial Announced

News today of a parallel Sansrosa Phase III Trial. This just announced trial is shorter than the Long Term (52 week) Safety Trial, and seeks to confirm that Sansrosa Gel (CD07805/47) is more effective than the inactive vehicle gel and is itself a safe treatment. Trial ID: NCT01355458 (seems to be somewhat duplicated with NCT01355471) …

4. Vanicream Moisturizing Skin Cream User Reviews

I harp on about this a lot, but I think it is worth repeating. A gentle skin care regime is a good thing for your rosacea. We know …

5. Tetrapeptide-14: Now available for Eye Puffiness and Redness

Some news today promoting a product claimed to reduce the appearance of under eye puffiness. Tarte Dark Circle Defense claims the inclusion of a Helix Biomedix designed peptide sequence known as Tetrapeptide-14 is responsible for the anti-inflammatory actions of the concealer.

6. AzaClear: Moisturizer with Azelaic Acid and Niacinamide

Epikinetics Pharma has pushed out a press release today (reproduced in full on sfgate.com …

7. Why should I Cleanse and Moisturize my dry, oily, flaky SD skin?

I came across this thread in the archives and thought it was worth highlighting it and pushing it out again.

The question asked is a good one – how can cleansing and moisturizing the dry flaky and oily SD skin be a good thing? If you have ever wondered why this is so, read on.

It was interesting to read again how for severely sensitive skin, repairing …

8. FTC Gets Tough on Acai Berry Supplement Sites

Recently the Federal Trade Commission announced that it was taking legal action against businesses that operate deceptive supplement web sites, specifically sites that selling Acai Berry based products.
What does this have to do with Rosacea?
A fair question. As the internet has become a more and more popular source for health related information, the trustworthiness of web sites has become more and more important.

9. Atopiclair, Eletone, MimyX: Barrier Creams with No Active Ingredients

Thanks to Beth, here is some more information about a class of FDA Approved “Medical Device” creams. This class of creams are prescription only, contain no active molecules and are approved for sale to treat medical conditions under via the provisions of …

Rosacea News April 2011

2011-05-11T06:11:00.001-07:00

Rosacea News April 2011

1. LA Clinic looking for Oracea Biomarkers Study Participants

The Vitligo and Pigmentation Institute of Southern California is hosting part of the trial to evaluate Rosacea-related Inflammatory Biochemical Markers in Adult Skin When Treated With Oracea vs Placebo. This trial is looking to prove changes in inflammatory markers like the peptide LL-37 and the MMP family match the improvement seen when taking Oracea. The trial is scheduled to involve 170 participants at …

2. Why, Oh Why Did I Get Rosacea ?

I hear you.

My skin was great. I have had beautiful skin all my life, but now wham! rosacea has reared its ugly head.

Well the NRS Blog has an answer to this plea. It is all about your risk profile. If you are over 30 with fair skin, have a relative with rosacea and are of Northern European Ancestry then the statistics suggest that you are …

3. Galderma Big Profits Great for Texas

An interesting article from the Business section of the Star-Telegram about the local presence of Galderma in Fort Worth, Texas. Galderma is one of the key companies for rosacea sufferers to follow given their products such as Cetaphil, Metrogel, Oracea and the in-development Sansrosa. Swiss skin-care company thrives even during hard times, executive notes at …

4. Vicept Oxymetazoline V-101 Cream More Phase II Data, on to Phase III

A Press Release today (Vicept are happy to generate publicity at every step of their development) touting more Phase II Study results for their Oxymetazoline based V-101 product. V-101 is a topical slated to treat the redness of …

5. The BEST Treatment for Rosacea

Once you have been diagnosed with rosacea, everyone naturally wants to know What is the best treatment for rosacea? Wouldn’t it be great if there was a simple answer to this question that satisfied everyone who has rosacea! Hopefully it doesn’t come as a surprise to find out that there is no known panacea for rosacea. This high level paper …

6. Generic Oracea Legal Trial now in July 2011

I have been watching for a while to see for any developments in the legal proceedings between Mylan and Galderma. These proceedings will determine whether Mylan is allowed to sell Generic Oracea. This is of interest to many rosacea sufferers who consider that Oracea is too …

7. Medicis and Anacor to Develop Boron Treatments for Acne

Even though this press release relates to Acne, it is still interesting to see companies searching for the next killer acne treatment. Whilst only some acne treatments are successful as rosacea treatments, we can still …

8. Green Jelly Beans Linked to Acne!

OK so now I have gotten your attention. Have read of this comic. Lets talk after you finish reading it. xkcd: Significant …

9. Nailfold Capillaroscopy: If only Rosacea was that Easy to Diagnose

I thought this abstract was interesting because of its failure. The authors proposed that a passive diagnostic test known as Nailfold Cappillaroscopy could be used to test for rosacea.

Rosacea News March 2011

2011-04-11T19:17:00.001-07:00

1. Gallo: beta-defensins coordinate Skin Barrier Injuries

This short abstract from Dr. Richard Gallo is an introduction to an article further on in the journal edition from Dr. Ahrens et al. Gallo’s interest is piqued by the possibility of a coordinated defense effort from the permeability and antimicrobial barriers of the skin. Ahrens was able to show that certain Antimicrobial peptides (AMPs), called beta-defensins were upregulated (i.e. they …

2. Dry Eye is a common precursor to Ocular Rosacea

This abstract suggests that dry eye may be an early sign of ocular rosacea. Tear function tests could help the early diagnosis of ocular rosacea, according to the authors. Currently there is no definitive diagnostic test for ocular rosacea, it is based on clinical symptoms. One proposed diagnostic test is high abundance of oligosaccharides in the tear fluid of patients with rosacea. …

3. Ever heard of a Rx Cream with NO ACTIVE INGREDIENTS?

In all of your internet searching for treatments, have you ever come across a FDA approved, prescription-only treatment that claims to have no active ingredients ? Would you stop and think What is that all about? Well I did. The supporting web site for Promiseb Topical Cream (online at http://promiseb.com/) contains a very …

4. Itchy Gritty Eyes may be Blepharitis

An unusually useful article about Blepharitis today from The Herald Times Reporter, Manitowoc, Wisconsin. (htrnews.com). Itchy, sandy feeling in eyelids may be blepharitis Question: What causes my eyelids to be itchy and sandy in the mornings? Answer: The most likely cause of your symptoms is something called blepharitis, or inflammation of the eyelids, and …

5. Sansrosa starts Phase 3 Trials (again)

News today that Galderma has listed CD07805/47 as entering large scale Phase III trials. Under the previous owners of the Brimonidine-based technology Collagenex, the product then known as Sansrosa …

6. The Rosacea App: A Rosacea Web Site in your pocket

This is a first. A major pharmaceutical company has released a smart phone app for rosacea sufferers. Intendis, the makers of Finacea, have created a program that you can carry around for easy reference.

Built with the help …

7. Finacea plus Low Dose Accutane to treat Seborrheic Dermatitis + Rosacea + AK

Below is a recent paper suggesting that combining Finacea with Low Dose Accutane is a useful treatment for rosacea concomitant with seborrheic dermatitis. The patient was also suffering from Actinic Keratosis (pre-cancerous skin lesions). The patient experienced relief from both rosacea and seborrheic dermatitis, two conditions that together sometimes prove tricky to treat. Bear in mind, though, that this paper …

8. Intendis makes a mobile phone app for Rosacea

Intendis, the makers of Finacea, have announced that they are to produce an application for mobile phones to help sufferers of rosacea manage their symptoms. To be launched in March, the Rosacea Info App will be available for iPhone, BlackBerry and Android. Previously Rosacea News covered a program called AcneApp that purported to treat acne by displaying a solid red or …

9. Galderma, with Oracea looking for Inflammatory Pathway Markers

Seemingly wanting to help answer the question How do tetracyclines help Rosacea? Galderma has announced a large trial to measure the changes in inflammatory pathway markers when you take Oracea.

Whilst the trial only directly mentions LL-37 and MMP I would expect other well known markers to be measured as well.

If the researchers include markers that can be proven to be indicative of rosacea disease, …

10, The Placebo Effect is a very strange thing indeed

How exactly does the mind play a role in the way that medicines help us ? How come even when we know the treatment is fake, we can get better ? Should we be asking our doctor for a bottle of placebo pills the next time we visit ? I would love to know the answer to these questions and …

11. Xylometazoline (Otrivin) is another red face treatment

A brief extract today covering a paper detailing how the topical Xylometazoline can be used to treat the redness of rosacea.

Similar to oxymetazoline, xylometazoline is marketed as a nasal decongestant under many brand names. Brands you may come across include Otrivine, Otrivin, Sinutab Nasal Spray, Cirovin and Novorin.

Rosacea News February 2011

2011-03-03T23:03:00.001-08:00

Rosacea News February 2011

1. 4% Quassia Amara Extract as good as Metrogel and Finacea

A just published abstract introduces a botanical extract for the treatment of rosacea. Researchers from the National University of Córdoba in Spain compared a topical gel containing 4% Quassia Amara with Metrogel and Finacea. The extract compared favourably to these established rosacea topicals, and thus might offer an alternative …

2. Tea Tree Oil may help skin cancer lesions

Some recent studies highlighted today from the University of Western Australia’s Tea Tree Oil Research Group. Who would have known that tea tree oil was interesting enough to have its own research group! Tea tree oil is interesting to rosacea sufferers firstly because it has been shown that tea tree oil can demodex mites. Secondly there is some research that shows that tea tree …

3. Bad Acne can lead to suicidal thoughts in teenagers

This study, undertaken in Norway finds that bad acne can of its own accord, induce suicidal thoughts in teenagers. Being a teenager can be tough. Being a teenager with bad skin and good mental health can be even tougher. If this study bears out in the larger population, then it is worth knowing that acne alone can be responsible for teenagers, most …

4. Neuropeptide PACAP Modulators for Neurogenic Rosacea

The recently published paper that called for the creation of Neurogenic Rosacea subtype contained an interesting disclosure.

We are told that one of the paper’s authors, Professor Martin Steinhoff MD PhD , holds a related patent and research grant from Galderma.
Related Rosacea Grant
Dr. Steinhoff, along with Dr. Feramisco, received a $25,000 grant in 2010 from the National Rosacea Society.

Perhaps this below is the grant …

5. How do you treat Neurogenic Rosacea?

This article is the third in a series featuring Neurogenic Rosacea. The first two articles are here: Neurogenic Rosacea: a new subtype for those with dysfunctional facial nerves and What is Neurogenic Rosacea?

Recently a group of doctors from Stanford became the first to publish a …

6. What is Neurogenic Rosacea?

A recent paper in Archives of Dermatology proposed a new rosacea subtype that is to be called Neurogenic Rosacea.

Before we tackle the question of What is neurogenic rosacea?, and How do I know if I have it?, lets step back and look at why a new subtype might be helpful.

7. Neurogenic Rosacea: a new subtype for those with dysfunctional facial nerves

A just-published paper in the Archives of Dermatology is calling for the recognition of a new rosacea subtype – Neurogenic Rosacea.

Rosacea News January 2011

2011-02-03T03:46:00.001-08:00

Rosacea News January 2011

1. SkinMedica Redness Relief CalmPlex launches to replace Cutanix DRL

We were tipped off by a comment on the blog posting about Cutanix going offline, to the possible future availability of a Cutanix like product. The commenter, who works for SkinMedica told us that; skincarejunkie Bioform was sold to Merz Aesthetics. In that sale Cutanix was sold to SkinMedica. …

2. AAD: your Vitamin D should come from diet, not the sun

Thanks for the tip from the Clinuvel Blog. The AAD has issued an Updated Position Statement on Vitamin D. The AAD’s position is that there is NO SAFE THRESHOLD for sun or indoor tanning exposure, and that we ought to get our recommended daily allowance for Vitamin D from our diet.

3. Sansrosa delayed, sufferers make their own Brimonidine, BEWARE

The path from the laboratory for Sansrosa / COL-118 / CD07805/47 to a product that realises the promise of permanently reducing a red face has been a long one. We first heard about a product to become known …

4. Cutis posts Oracea Phase 4 (ORCA) papers for free online

Late last year Galderma generated quite a lot of publicity in the lead up to the release of the Phase 4 trials of Oracea. Phase IV trials typically …

5. Aczone is as good as Oracea, Finacea or Metrogel, apparently

Trolling patent applications is pretty turgid work. Mostly patents seem to be intellectuals marking out their claims in the hope that future products might result from their discoveries. This patent application starts badly with firstly spelling Rosacea incorrectly as Rosascea.

6. Combining Ivermectin + Benzoyl Peroxide in a topical

A recently updated patent, assigned to Galderma suggests a rosacea topical comprising “at least one compound of the avermectin family and benzoyl peroxide”. This is an unusual (or novel, depending on your viewpoint I suppose) pairing of ingredients for a topical treatment for rosacea symptoms. If you search patents online you can also find applications for topicals containing Avermectin + Metronidazole and …

7. Book Review: Acne and Rosacea The Complete Guide, Alison Bowser

The book is written in 3 parts – 1. Acne (135 pages), 2. Rosacea (25 pages) and 3. Caring for Acne and Rosacea Skin (39 pages).

8. Top Blog Posts on rosacea-support.org

Now that 2010 is over, a quick look at the overall most popular pages on rosacea-support.org. Most Popular Posts Overall The following 10 web site pages were the most popular overall for the year: Photos of Red Nose, Papules, Pustules, acne like rosacea How to Cure a Red Face (facial erythema or …

Rosacea News December 2010

2011-01-03T19:34:00.001-08:00

1. Lupin Pharmaceuticals also files ANDA for Generic Oracea

The battle to make generic Oracea available to the public is heating up. Recently filed documents in Delaware show that Lupin Pharmaceuticals, which are based in India have filed for …

2. Laser still the best for Spider Veins on the Face (WSJ)

An article today in the Wall Street Journal’s Health Aches & Claims section discusses treatments that are available to remove spider veins that can develop on the face. The author quotes Dr. David Goldberg who is well know to rosacea sufferers as a director of Skin Laser & Surgery Specialists of New York and New Jersey and a clinical professor of dermatology and director …

3. Rosaclear from Obagi as an Integrated Rosacea Treatment Regime

The idea of using an American Academy of Dermatology Poster session paper to introduce research around a new product is nothing new. Getting a poster session approved is easier than a full …

4. Doxycycline is as good as Low Dose Accutane (0.3mg/kg/day)

This study as described in a AAD Poster Session, compared 3 different doses of isotretinoin/accutane with a somewhat standard low dose regime of doxycyline. The study was able to show that 0.3mg/kg/day of accutane was as effective as 100mg of Doxycycline for 14 days; followed by 50mg a day thereafter. A dose of accutane of 0.3mg/kg/day is 18mg per day for a …

5. Finacea Foam vs. Finacea Gel

This time last year we learned that Finacea Foam was being trialled for rosacea. That 2009 initiated trial was to compare Finacea Foam against the placebo foam vehicle.

Now a new trial has been listed to compare Finacea Gel with Finacea Foam.

As I noted a year ago, these kind of `swings and roundabouts’ trials tend to be seen when a product reaches maturity and the …

6. What role do micro-organisms in play in Rosacea?

This abstract promises to tell us everything we need to know about the possible role of micro-organisms in the way that the disease Rosacea starts and develops. Even though the role of published research is not to provide reading material for the general public, I still look to journal …

7. Sunscreen does indeed help prevent Melanoma

Apparently this is new information; a study has for the firs time found evidence that sunscreen can help prevent the deadly skin cancer melanoma.

I had assumed that this was a well known fact, but this is not …

8. Rosacea’s Inflammation Mechanisms: Symposium Notes

Thanks for the tip from Dan, here is an interesting presentation from the AAD Summer Academy Meeting, August 4-8, Chicago, Ill. The notes are titled Acne and Rosacea: Inflammatory mechanisms and their impact on therapy and were part of Symposium S012. The Symposium was titled What’s Breaking Out: Acne and Rosacea. Dr. Bhatia was the first speaker, and was down to cover this …

9. Topical Timolol (Timoptic) for rosacea lesions around the eye

A new clinical trial is proposing to look at using a non-cardioselective beta-blocker, Timolol Opthalmic, to treat ocular rosacea based benign vascular lesions on the eyelid. The condition is chronic as it can lead to blindness. Timolol has been used orally in the treatment for hypertension and opthalmic solutions have been used to reduce intraocular pressure in glaucoma. Clinical …

Rosacea News November 2010

2010-11-30T21:12:00.001-08:00

1. Finacea and the Cause of Rosacea

Following on from a study that was able to show the reason that Finacea was able to adjust the inflammatory response in the skin, is this JAAD Poster session abstract. This paper is looking at how the active ingredient in Finacea, azelaic acid can decrease the expression of 2 substances thought to be important in rosacea – kallikrein 5 (KLK5) and cathelicidin. The …

2. Oracea Phase IV Results (ORCA) show users are happy

Promoted as the biggest rosacea study ever undertaken, Galderma has released results from the Phase IV study into Oracea. This study was called ORCA. We learn from the Galderma Press Release that ORCA stands for Oracea for Rosacea: A Community-Based Assessment. We also learn how to correctly pronounce Oracea, should that interest you. Phase IV trials typically try to replicate the success and safety

3. The one thing I wish I was told about treating Rosacea

Do you have something that you just wish you were told when you were first diagnosed with rosacea? What little pearl of wisdom would have made the biggest difference to know straight up?

Often when someone is diagnosed with rosacea, their first trip to the internet is a scary one. Those pictures of the worst cases of severe rosacea are enough to depress anyone.

4. Elorac promoting Carbamide Peroxide as a Rosacea Treatment

A recent press release from a company called Elorac, is highlighting Phase II trials for treating Acne with Carbamide Peroxide. Elorac are promoting Carbamide Peroxide as an improved, next-generation version …

5. High Glycemic Diet Exacerbates Acne

This may come as no surprise to many, but there continues to be a strong link between diets that place a high glycemic load on the body and acne. Diet and acne, Bowe WP, Joshi SS, Shalita AR. J Am Acad Dermatol. 2010 Jul;63(1):124-41. Historically, the relationship between diet and acne has been highly controversial. Before the …

6. DERMAdoctor Photodynamic Therapy – topical Red Light Therapy?

Thanks to a comment from Aimee, there is a new product available from DERMAdoctor that looks both innovative and potentially beneficial for rosacea sufferers.

The makers claim that DERMAdoctor Photodynamic Therapy enables users to “experience continuous exposure to anti-aging red light through the mere application of a lotion” and call it a “ground-breaking, patent-pending solar powered technology in lotion form captures UV light transforming it into visible red light, a proven energy source for eliciting anti-aging effects on the skin”.

Rosacea News October 2010

2010-11-08T05:39:00.001-08:00

Rosacea News October 2010

1. Scenesse effective for Solar Urticaria

For those following the progress of the development of Scenesse (formerly Afamelanotide), some good results from Phase II trials in treating Solar Urticaria. Solar Urticaria is a rare skin condition that can be thought of as being like hives caused my exposure to the sun. Participants received a 16mg implant of Scenesse and were found to have both a significant …

2. Mylan continues to fight for Generic Oracea

Documents recently filed in the Mylan vs. Galderma patent litigation reveal that Mylan Pharmaceuticals continues to argue that it should be allowed to manufacture generic Oracea. This ongoing battle is known as the “Oracea Patent Litigation”.

If you are interested to see how generic pharma takes on big pharma to get a …

3. Vanicream Sunscreens User Reviews

Liked by rosacea sufferers for being mild, elegant and reasonably priced, Vanicream Sunscreen SPF30 and SPF60 offer strong sun protection in a formulation worth trying out.

Vanicream Sunscreen is available in SPF30, SPF35 and SPF60. The SPF30 and …

4. Skin Bacteria Thrives in Rosacea Patients

This just published abstract has two interesting findings. Firstly the majority of pustules from a group of rosacea sufferers contained a growth of a skin bacteria called Staphylococcus epidermidis, whereas normal skin …

5. Trial Watch: New Treatments Coming Soon

Despite the global financial economic situation and despite the seemingly crowded skincare market, the research and development of rosacea treatments continues at pace. I wonder if you would be …

6. Raman Spectroscopy, the next great diagnosis innovation

Some press this week about an emerging diagnostic technology known as Raman Spectroscopy. Raman Spectroscopy looks at the way that light scatters when it interacts with different molecules. The technology can analyse the scatter patterns to determine exacting details to do with the chemical makeup of the tissue being examined.

The article suggests that Raman Spectroscopy can be used in a whole new range of ways in a diagnostic role.

Rosacea News September 2010

2010-10-28T06:17:00.001-07:00

1. New Rosacea Treatments – get them while they’re hot

Every rosacea sufferer who is unsatisfied with the current offering of treatments looks to see what might be available soon. The thought that something new and improved is just around the corner is a source of encouragement for sufferers …

2. Cutanea Life Sciences files IPO to fund Omiganan development

News today that yet another company is accessing funding to pursue research and development for a new treatment targeting the papules and pustules of rosacea. We learnt in 2006 that Cutanea were trialing Omiganan for rosacea. The treatment is known as a topical cationic peptide. This treatment has anti-inflammatory properties that were promising for acne. Now the developers are …

3. Does the internet help us become hypochondriacs?

A really interesting and honest article where the writer tells us how she has always been very anxious about her health, worrying about many incidences that turned out to be fine. One great fear was leaving her children without a mother. Self diagnosing from the internet certainly didn’t help her anxiety, it would seem. Having the resource of the internet for health issues is …

4. Our love-hate relationship with the Sun

If you are like me, that is like most rosacea sufferers, you wonder where is the middle ground with our relationship to the sun. It seems that each month a new tiny bit of research shows that Vitamin …

5. Los Angeles: facial redness trialists wanted

I have been contacted by Impact Clinical Trials in Los Angeles who are looking for rosacea patients to participate in the ongoing trials for a `new topical gel’ for the erythema associated with rosacea. We are currently conducting a study for a new topical gel being developed as a possible future treatment of erythema associated with rosacea. We are looking for …

6. The NRS wants your blood !!

The National Rosacea Society is calling for people to be materially involved with a study they have funded that is looking into the possible genetic link with the neurovascular system of rosacea sufferers. It would be a great discovery if a gene responsible for facial flushing and burning could indeed be isolated. Help New Genetics Study …

7. Oxymetazoline: what about rebound redness ?

One of the up and coming treatments for the redness of rosacea is the use of oxymetazoline based formulations. Oxymetazoline is the active ingredient in decongestant products like Afrin, Sudafed OM and Vicks Sinex as well as …

8. New Jersey: Want to participate in an Anti-Redness trial?

The recruiting manager from Frontage Clinical is looking for participants in the trial they are hosting for rosacea redness. Frontage Clinical in Hackensack, NJ is conducting a research study to evaluate the safety of an investigational topical gel medication for moderate to severe facial redness associated with ROSACEA. All qualified participants will receive at no cost …

Rosacea News August 2010

2010-09-13T07:06:00.001-07:00

Rosacea News August 2010

1. Soho, NY. Studio looking for makeup volunteers

I have been contacted by Mana Products to see if an volunteers are interested in a makeup session at the Soho, New York Studio. Please contact Adrienne if you are interested. It looks like their web site is www.manaproducts.com We are working on a new cosmetic line of gentle, effective products to conceal rosacea and other skin flaws and create …

2. Extina, Ketoconazole you can use on your face

A formulation of Ketoconazole 2% for treating seborrheic dermatitis called Extina is currently being promoted by Stiefel Laboratories. Stiefel, which is a part of GSK, is promoting Extina as the “first and only ketoconazole foam for scalp, …

3. V-101 (Oxymetazoline) starting Dose-Finding Trials

Hot on the trail of the Phase 1 Study Results and Funding Announcement is a listing confirming that Vicept Therapeutics are soon to start dose finding trials for the treatment of the redness of rosacea. The trial will study the efficacy of V-101 Cream, applied once per day, at a low dose of 0.01%, 2 lots of mid-dose of 0.06% and 0.1%, …

4. Mediterranean Diet gives you Sun Protection

Thanks to a tip from ClinuvelNews, here is an article in ScienceDaily pointing us to some recent research that shows that a diet rich in antioxidants and omega-3 fatty acids can protect us from skin cancer. In countries like Australia and New Zealand that have high incidences of melanoma, this is some additional reason to follow a diet rich in these nutrients.

5. Vicept Therapeutics positive Phase I study of V-101 for redness of Rosacea

With this latest press release, Vicept Therapeutics is now well and truly out in the public view, and attracting interest from rosacea sufferers. This release of results for Phase I trials of V-101 comes after news that Vicept Therapeutics had secured funding for the development of V-101.

Now that a company name has surfaced we can put the pieces together back to 2007 when Rosacea …

6. Galderma sends Sansrosa backwards – Phase 2 Dosage Trials Again

In yet more proof that Galderma wants to sit on the drug known as Sansrosa, a new August 2010 Phase II dose finding study has been listed at clinicaltrials.gov.

Rosacea News July 2010

2010-08-18T19:16:00.001-07:00

Rosacea News July 2010

1. The Wheels on the Bus Go Round and Round

Just published in the June 2010 edition of the Journal of Drugs in Dermatology is a study comparing “Finacea in combination with Oracea” with “Metrogel in combination with Oracea”. Seeing this abstract published makes me want to let out a loud groan. So much of what we see as recently published rosacea research is just recycled sameness. The actual result of most …

2. Pyratine XR offers long term benefits

Always quick to generate a press release, Pyratine XR has been seen some recently published research, this time on the long term efficacy when treating mild to moderate rosacea. This latest research is in addition to the …

3. The Innovation of Natural Ingredients in Skin Care products

Are skin care products better for your skin, and less likely to be bad for rosacea sufferers, just because they contain natural ingredients ? Of course the answer to this seemingly simple question answer is not straight forward.

Regardless of the answer to this question, the interest in natural products to treat …

4. ROSIE: a new Rosacea Expert Group

With this recent abstract we learn about a new group of International Rosacea Experts.

Up until now the best known group of rosacea experts was organised by the National Rosacea Society, and was referred to as the Rosacea Expert Committee.

The NRS Expert Committee over the years has been responsible for amongst others the 4 following landmark rosacea publications;

Standard Classification of Rosacea
Standard Grading System …

5. NRS Blog highlights ocular demodex bacteria correlation

The NRS Blog has an article today which is an easy to read summary of some recent research into ocular symptoms and demodex mite bacteria. Mites and Eye Symptoms A new study has found there may be a link between ocular rosacea and bacteria associated with Demodex mites, microscopic inhabitants of normal skin that tend to …

6. Generic Oracea in First Quarter 2011 ?

A market analyst report just published speculates that Mylan Inc. may be in a position to market Generic Oracea as soon as the first quarter of 2011. These speculations are based on the successful outcome of a trial set down for December 2010 where Mylan will argue …

7. DRx AFC Medirepair (Arazine) now available in Japan

Signum Biosciences have announced that their first generation “Signal Transduction Modulator” product, AFC Medirepair (Arazine), is now officially available in Japan. From the product web site, the product has some other related products names such as Skin …

8. Vicept Therapeutics gets funding for V-101

News across the business web sites today a new company obtaining funding for a patent protected alpha-adrenergic receptor based treatment for the redness of rosacea.

Vicept Therapuetics is based in Malvern in Pennsylvania and is a privately held company.
From Fidelity Biosciences Joins $10M Series A for Vicept Therapeutics

“We are delighted by the strong investor interest in this round of financing which will allow us to …

Rosacea News June 2010

2010-07-19T06:01:00.001-07:00

Rosacea News June 2010

1. How many people suffer from Rosacea ?

One of the areas of research that attracts attention in the press and it also interesting to rosacea sufferers revolves around how many people have rosacea. The latest 2010 estimates from the NRS suggest that 16 million Americans suffer from rosacea, up from the last estimate of 14 million.

The incidence of rosacea is studied because there is a belief that the statistical analysis will …

2. Just how does Finacea work ?

I’m not sure that I have laid awake at night wondering about how exactly finacea does it’s thing, but as Rosacea News had a stab at Just how does metrogel work ? a while ago, an attempt at covering Finacea’s method of action is only fair.

It is interesting to consider how finacea works especially if that knowledge might lead to …

3. Vitamin D may help the Flu as well

Vitamin D continues to attract interest as does the list of ailments that are now associated with this nutrient. We know from previous studies that Vitamin D modulates the production of cytokines, thereby suppressing inflammation, but here we see that this has been linked not to rosacea, but viral infections such as the flu. Serum 25-Hydroxyvitamin D and the Incidence …

4. Finacea now available in Canada

Canadian rosacea sufferers have up until now been unable to officially use Finacea. Bayer HealthCare Pharmaceuticals have announced that Finacea is now available in Canada. Finally Canadians can get access to Finacea via prescription bringing them …

5. What rosacea topic do you most want to read about ?

If you could ask for a topic for an article on rosacea, what would you ask for ? I have been approached by someone who is contemplating writing an article that would be interesting for rosacea sufferers to read. This article could be published in a magazine or journal and depending on the topic could contain some useful research as well. So here …

6. Foamix to trial foaming topical minocycline

The prescription topical market for rosacea seems to be somewhat crowded. Sufferers have the choice of the metrogel family, finacea as well as the potential to try acne topicals such as retinoids. So far there hasn’t been a proven topical anti-biotic per se. Metrogel and Finacea have anti-inflammatory properties, but are not classified as anti-biotics.

Rosacea News May 2010

2010-06-04T08:16:00.001-07:00

Rosacea News May 2010

1. Cetaphil RestoraDERM for extra dry skin and Eczema

Already available in Canada, Cetaphil will introduce a new line of products for dry sensitive skin in August in the US. The line is called RestoraDERM and is targeted at Eczema sufferers who struggle to maintain the natural moisture balance of their skin. For those rosacea sufferers who also …

2. Research Briefs: IPL, Laser and Stress

Here are brief mentions of recently published papers that look interesting to rosacea sufferers.

1. Intense pulsed light in the treatment of non-aesthetic facial and neck vascular lesions: report of 85 cases

IPL treatments were given 4-6 times 3 weeks apart. 35 rosacea `lesions’ were studied overall. The abstract links the results of rosacea and Poikiloderma of Civatte together, saying that the vast majority of lesions …

3. NRS on Beta Blockers and flushing

In the latest edition of Ask the Doctors, Dr. Jonathan Wilkin, chairman of the NRS medical advisory board answers the question `Do beta-blockers help reduce flushing from rosacea?’.

The answer is brief but I’m encouraged to see the NRS discussing further the possibility of using beta blockers for flushing in rosacea sufferers.
In severe cases, a beta-blocker may sometimes be prescribed to help reduce emotionally triggered flushing …

4. Atralin Gel (Tretinoin 0.05%) being trialled for the redness of Rosacea

The Clinical Trials Register is listing a new trial today for a topical retinoid, Atralin Gel 0.05% for the treatment of the redness and broken blood vessels of rosacea. Officially the trial will look at the redness, telangiectasia, …

5. SIG990 Excellent for Redness, several years away

In a recent email to Rosacea News, Dr. Eduardo Pérez, VP of Operations at Signum Biosciences has confirmed that SIG990 is undergoing preclinical safety/toxicology testing as required by the FDA before clinical trials can commence. You can see this confirmed at the company’s web site: Pharmaceutical Development Pipeline. Signum Biosciences has several molecules under development, SIG990 is their lead candidate for rosacea. …

6. Afamelanotide (Scenesse) now available in Italy

Clinuvel has announced today that Italy has pre-empted the approval of Afamelanotide by the FDA in the US by approving it for the treatment of erythropoietic protoporphyria (EPP).

7. An interview with Colin Dahl from Australian Sciences

Our first guest is Colin Dahl, Chief Scientist at Australian Sciences and the author of A Practical Understanding of Rosacea, Part 1: Heat Regulation and the Warm Room Flush Phenomenon that has been of great help to many rosacea sufferers. We hope you will find these interviews an interesting read.

Scenesse now available in Italy

2010-05-18T00:34:00.001-07:00

Clinuvel has announced today that Italy has pre-empted the approval of Afamelanotide (Scenesse) by the FDA in the US by approving it for the treatment of erythropoietic protoporphyria (EPP).

Despite the relatively small number of participants in the Italian trial to treat EPP, and the small number of EPP sufferers thought to directly benefit from this therapy, the approval by Italian Medicines Agency (AIFA) is significant because it confirms Afamelanotide’s efficacy and safety and also that national medicine agencies are willing to rapidly approve afamelanotide.

Clinuvel have also announced that afamelanotide will be marketed under the brand name of Scenesse (pronounced “sen-esse”). From today onwards, Clinuvel will adopt SCENESSE in all references to the drug in its further global clinical development.

Scenesse now available in Italy

2010-05-18T00:30:00.001-07:00

Clinuvel has announced today that Italy has pre-empted the approval of Afamelanotide by the FDA in the US by approving it for the treatment of erythropoietic protoporphyria (EPP).

Rosacea News April 2010

2010-05-06T22:31:00.001-07:00

Rosacea News April 2010

1. Gut Bacteria and Xifaxan get some press coverage

April 30th, 2010, by David Pascoe

The St. Louis-Dispatch has an article today exploring the link between the overgrowth of small intestinal bacteria and rosacea symptoms for some rosacea sufferers. New way to treat skin disorder By Cynthia Billhartz Gregorian, ST. LOUIS POST-DISPATCH, 04/29/2010 … Weinstock is not a dermatologist. He’s a founding partner …

2. Ocular symptoms match Demodex Bacteria reaction too

April 29th, 2010, by David Pascoe

This paper is one more small achievement using statistics to try to build a picture of how demodex mites might be involved with rosacea symptoms. We have learnt from recent research that rosacea sufferers are sensitive to 2 particular types of bacteria that have been isolated in demodex mites. This study further establishes that a reaction to the bacteria correlates to ocular …

3. Light Masque: a LED array from the future

April 27th, 2010, by David Pascoe

The Daily Mail has a recent article looking at a futuristic LED array that wraps around your whole face. Along with a brief review of the device, the author finds it hard to wrap their mind around the claimed …

4. NHS should stop funding Homeopathy: MPs

April 26th, 2010, by David Pascoe

A recent submission to the House of Commons Science and Technology Committee has said that using public money on the highly-diluted remedies of homeopathy could not be justified. The cross-party group said there was no evidence beyond a placebo effect, when a patient gets better because of …

5. NRS Announces 2010 Research Grants

April 23rd, 2010, by David Pascoe

The National Rosacea Society has announced a new round of grant funding. Three new studies have been given a grant as well as continuing the ongoing research of 3 studies. Research Grants Awarded Thursday, April 22, 2010 The National Rosacea Society (NRS) has awarded funding to three new studies and continues to fund three …

6. RRDi journal Issue 1 Review: an unfortunate mix

April 21st, 2010, by David Pascoe

The RRDi recently published the first issue of their journal. Rosacea News was given a pre-print version to review. Volume 1, Number 1 is 88 pages and is available for around $15. I was quietly hopeful that a publication `produced by volunteers and written by dermatologists, physicians, researchers and patients’ could be something worthwhile and progressive for the field of rosacea. Sadly my …

7. Accutane Dose 22mg a day compares well to low doses of Doxycycline

April 20th, 2010, by David Pascoe

A paper that Rosacea News previewed in November last year: Accutane dose of 22mg a day works best: EADV has now been published in the JDDG: Journal of German Society of Dermatology. As we learned from the …

8. Every cloud has a silver lining

April 18th, 2010, by E.L. Hodge

European rosaceans unable to fly right now might temper their frustration with the thought that the subtle atmospheric changes caused by the eruption of Eyjafjallajökull might just be helping their symptoms. The volcanic stuff being spewed into the air is rich in sulphurous materials. Sulphur, of course, is a well established rosacea topical. Now, you may be sure that this is no desperate effort …

9. Cure Your Rosacea: ebook review

April 16th, 2010, by David Pascoe

I was sent a copy of the ebook that is for sale at www.cureyourrosacea.com to review. Here are my thoughts on what the author says took 10 years to discover and write. I wasn’t that thrilled to see the web site that sells this ebook sporting a blue+yellow sunflower theme. The sunflower theme has branded rosacea-support.org for several years now and I …

10. Signum Biosciences developing SIG990 for Rosacea

April 15th, 2010, by David Pascoe

A company called Signum Biosciences is developing a new product to target rosacea. Based on a technology that they call G-protein Modulators, GPMs are said to “restore signalling imbalances in the cell”. A first generation product called Arazine is soon to become available and a second generation of products are to target rosacea, psoriasis and eczema.

According to Signum Bioscience’s Development Pipeline, SIG990 is in …

11. Placebo Treatments work even if you know they’re fake

April 14th, 2010, by David Pascoe

An interesting piece in the Australian media recently looking at whether treating patients knowingly with placebo treatments might actually offer some benefits. I have always been fascinated with the whole placebo effect. How exactly can our belief …

12. Inkjet that Sprays on Skin Cells for Burn Victims

April 12th, 2010, by David Pascoe

A press release via Reuters details a new and exciting alternative to skin grafts for burn victims. The method includes some stem cells which allows hair follicles and sebaceous glands to develop in the new layers of skin.

This development offers another possible avenue for rosacea treatments similar …

13. Face Transplant Recipient gets donor’s Rosacea

April 10th, 2010, by E.L. Hodge

As we all well know there are lots of things worse than rosacea. And, it turns out that one of the things worse than rosacea is having half a face. You see, James Maki who last year received a partial face transplant reports that, in spite of now being permanently red faced on account of the donor being a rosacean, he is very pleased …

14. Oracea and Metrogel FREE for low income no insurance

April 9th, 2010, by David Pascoe

Being prescription items, Oracea and Metrogel 1% are too expensive for many rosacea sufferers, even those with basic medical insurance.

Thanks to a tip from chenoarae; Oracea and Metrogel 1% are both available for free for residents of the US who don’t have insurance of any sort and are on a low income.

Some pharmaceutical companies offer a Patient Assistance Program (PAP) where they provide their …

15. Rosaliac UV Fortifying Anti-Redness Moisturizer with SPF 15

April 8th, 2010, by David Pascoe

La Roche-Posay are not particularly well known in the rosacea world but they do sponsor the National Rosacea Society and have a range …

16. Treating Dry Eye with Intense Pulsed Light

April 7th, 2010, by David Pascoe

KGMH Denver Channel 7 has a piece today, Drop-Free Dry Eye Treatment, highlighting the use of IPL for treating suffers of chronic Dry Eye.

17. Behind the statistics are Real People

April 2nd, 2010, by E.L. Hodge

A.D. 63. Rome. Public speaking is central to political and cultural life: an ordeal for most people; a nightmare for Roman rosaceans. The philosopher, Seneca, offers consolation to Lucilius, who is likely afflicted with ruddiness, flushing and blushing. ‘Certain people have ordinary blood,’ he says, ‘ and others just have an animated, lively sort of blood that comes to the face quickly.’

Rosacea News March 2010

2010-04-06T00:59:00.001-07:00

Rosacea News March 2010

1. Rosacea is just a drop in the Internet Ocean

March 31st, 2010, by David Pascoe | in the news |

Those that have been around the rosacea online community for a while tend to be very focused on rosacea. If you ask Google how many people are searching for particular keywords you can see a bit more perspective on where rosacea fits in the global internet consciousness….

2. Biochemics Patents Vasoactives to Enhance Laser Treatments

March 30th, 2010, by E.L. Hodge | flushing, laser therapy, patents |

Today we welcome a new writer for Rosacea News – E.L. Hodge. Great to have you and we are all looking forward to hearing more of your thoughts !

How to best optimize laser and IPL treatments has long been debated. Should the rosacean deliberately engineer a flush prior to treatment? Should anti-inflammatories or anti-hypertensives be taken after treatment? Of course, many have long since reached …

3. RRDi Calling for Papers for Volume 2

March 29th, 2010, by David Pascoe | research foundation |

Following on from RRDi publishes first edition of their Rosacea Journal is a call for papers for the next Volume. Call for Papers, RRDi Journal Volume 2 We welcome articles on any aspect of rosacea for the second volume of the RRDi Journal. Health professionals and researchers are invited to submit research articles, clinical trial …

4. British film crew seeks NHS patient with rosacea

March 27th, 2010, by David Pascoe | in the news |

A production company is preparing to shoot a film on rosacea for the NHS Choices website and would like to include a case study. The ideal candidate would be someone whose rosacea is being treated by a dermatologist under the NHS, who is progressing well with those treatments, and can speak fluently about what is involved. They will also be interviewing a rosacea specialist/dermatologist, who …

5. Galderma’s President on the dermatology market

March 25th, 2010, by David Pascoe | galderma, in the news |

A few short quips from the President of Galderma, François Fournier, on his thoughts on the dermatology market. Just a couple of points below that were interesting. For one, Galderma invests more in R&D

6. Oracea should be tested against Generic Doxycycline

March 24th, 2010, by David Pascoe | galderma, oracea, tetracyclines |

This just published abstract is looking at recent advances in the use of the tetracycline family in treating rosacea. Of course a lot of the interest in subantimicrobial dose doxycyline has been motivated by the introduction of the Oracea to the market. A previous published study instigated by Collagenex (now owned by Galderma) showed that 100mg doxycycline was no better than oracea in …

7. April is Rosacea Awareness Month, spread the word

March 23rd, 2010, by David Pascoe | in the news, research foundation |

I haven’t ever got that excited about the annual awareness month for rosacea, as, well I’m quite aware of it.

It is obvious though, from looking around the population that plenty of people are not aware of the condition.

Why don’t you, as a reader of Rosacea News, do something …

8. rhinophyma (permanent rosacea nose) research updates

March 20th, 2010, by David Pascoe | rhinophyma |

A few updates for rhinophyma have been published recently, worth mentioning here as a quick update. Carbon dioxide laser treatment of rhinophyma: a review of 124 patients. (Br J Dermatol. 2009 Oct;161(4):814-8. Epub 2009 Jul 14.) Gives the conclusion that “The CO2 laser is an effective and durable treatment for rhinophyma. Treatment carries …

9. Clarifoam EF good for Rosacea, Acne and Seborrheic Dermatitis

March 19th, 2010, by David Pascoe | acne treatments, seborrheic dermatitis,topicals, user reviews |

This just published paper details a `new’ product that comprises a slight twist on an old formula. It seems that much of modern research and development involves tweaking existing treatments to see how their efficacy and product lifecycle can be extended.

This new product is known as CLARIFOAM EF Emollient Foam, …

10. Clinique Even Better Skin Tone Corrector, is it for you ?

March 17th, 2010, by David Pascoe | clinique, skin care |

“Here’s the chance to virtually undo the visible evidence of sun damage, dark patches, age spots, even acne scarring. Gently. For all ethnicities”. So says the promotional material for Clinique’s Even Better Tone Corrector and makeup. “Not even a leading prescription ingredient is faster in creating a more even skin tone”. Sounds too good to be true. Also sounds like it might be …

11. RRDi publishes first edition of their Rosacea Journal

March 16th, 2010, by David Pascoe | research, research foundation |

Brady Barrows has announced that the RRDi has published the Journal of the Rosacea Research & Development Institute: Volume 1 Number 1, 2010. The journal has been produced by volunteer rosacea sufferers and consists of `articles by …

12. Finacea Plus (get $2 off CeraVe and $10 off Finacea)

March 12th, 2010, by David Pascoe | finacea |

Many rosacea sufferers don’t get to see how the large pharmaceutical companies are marketing rosacea treatments to physicians. The program list from the recent AAD meeting in Florida gives an idea of where and how these companies think they can best promote their prescription products. Recently Rosacea News highlighted what is seen as Galderma’s quest to own the rosacea market. Here we …

13. Can you treat Acne with your iPhone ?

March 10th, 2010, by David Pascoe | LED Therapy, acne treatments |

Thanks to ClinuvelNews for highlighting the a $1.99 USD application available for your iPhone that is said to treat your acne. The application displays a red or blue screen which you then hold up to your face, supposedly allowing your skin to be treated while you make a phone call. Here are example screen shots of what the introductory and red and blue …

14. Galderma wants to own the Rosacea Market

March 8th, 2010, by David Pascoe | galderma, in the news |

Galderma is a large multinational pharmaceutical company. They don’t have much in the way of internet blogs and online chatter so it is hard to get a feel for what makes them tick. In recent years Galderma has become the heavyweight of dermatology, especially in rosacea treatments. The program list from the recent AAD meeting in Florida gives an idea of where Galderma …

15. Dermalogica Close Shave Oil, it really works !

March 5th, 2010, by David Pascoe | shaving, skin care, user reviews |

I have to admit that I hate shaving. It seems such a waste of time to me. Every morning I need to devote 10-15 minutes to scrape the dead wire-like hair off my face. Not only is it messy, but it hurts. I have tried an electric …

16. Microskin now available in the US

March 4th, 2010, by David Pascoe | makeup, topicals |

Recently that the Australian company Microskin has opened an office in New York. The Brisbane office opened in July 2005, with the NY office opening in January 2010. Microskin mention rosacea as one of the conditions that they treat. The product is slated as a simulated second skin. The product is applied using a Stipple (a special type of sponge) …

17. Assess your skin age and apparent likelihood to get rosacea

March 3rd, 2010, by David Pascoe | in the news |

A recent article from ABC7 featuring a skin analysis tool called VISIA Complexion Analysis System. The article suggests that the system uses multiple measures, including a porphyrin count to predict how likely a person is to get acne or …

18. NYP Hospital looking for trial participants, oral rosacea treatment

March 2nd, 2010, by David Pascoe | clinical trials |

Department of Dermatology, New York Presbyterian Hospital at Columbia University The Clinical Research Unit is seeking men and women, at least 18 years old, to participate in a research study of a new oral investigational treatment for Rosacea. The study requires 10 visits over 16 weeks. Participants may be eligible to receive: Free facial skin examinations …

Rosacea Skin Care

2010-03-07T06:01:00.001-08:00

Finding what Rosacea Skin Care regime works for you is almost the most important step that any rosacea sufferer can take. It seems a bit too simple to be decisive, but time and time again we read about rosacea sufferers who get a heap better after they find the best moisturizer, sunscreen, cleanser even makeup that suits them.

Rosacea News Jan/Feb 2010

2010-03-01T18:34:00.001-08:00

1. Rosacea features on ABC-TV’s Good Morning America Health

ABC-TV’s Good Morning America Health has featured rosacea in a 7 minute segment broadcast on January 21st.

On the table you can see Oracea, Metrogel and Cetaphil products, all from Galderma. One shot shows the new Cetaphil UVA/UVB Defence SPF 50 as well …

2. Prescription topicals go on first

When rosacea sufferers are first diagnosed it can be confusing to know how to include prescription topicals into their daily skincare regime. Rosacea patients want to know both that their expensive prescription medication has the best chance of working …

3. Apremilast from Celgene being trialled for rosacea

The first time you hear of a new drug, you probably ask – what is it ? Well are you ready for a marketing mouthful – “Apremilast is a novel, orally available small molecule compound that exhibits anti-inflammatory activities through the suppression of multiple pro-inflammatory mediators including, TNF-alpha, interleukins 6, 17 & 23, and interferon-gamma among others.” Apremilast (CC-10004) has been trialled for …

4. Q&A with Clinuvel on Afamelanotide and Melanotan

There is a lot of interest amongst rosacea sufferers surrounding the possibility of some kind of systemic treatment that will offer better UV protection. Especially for those with severe triggers from sun exposure, treatments like Afamelanotide look promising. The CEO and Director of Clinuvel, Dr Philippe Wolgen, was kind enough to answer some questions relating to their developments and any potential tie-in with …

5. Nielson disciplined over Nase’s misrepresentations

The Texas Medical Board has issued a press release with a list of their most recent discipline orders. One of its orders relates to Dr. David Nielson.

Dr. Nielson became known to rosacea sufferers via the way that his Rosacea Institute of Texas was heavily promoted by Geoffrey Nase. The results being promised and the treatment protocols proposed raised the suspicion of some rosacea …

6. Albert Kligman, Acne and Rosacea Pioneer dies at age 93

The name Albert Kligman has been associated with dermatology for a very long time. Perhaps best known for his work with the acne treatment Retin-A, Dr. Kligman is credited with more than 1,500 publications on acne, rosacea, eczema, contact dermatitis and skin aging. According to Albert M. Kligman, 93, dermatology researcher, Dr. Kligman cowrote 14 books, beginning with Textbook on Dermatology, published by …

7. Just how many people have Rosacea ?

The prevalence of rosacea is an often reported fact. Most media releases will start with a statement of the number of rosacea sufferers in the US.

The latest 2010 estimates from the NRS suggest that 16 million Americans suffer from rosacea, up from the last estimate of …

8. 7 Up and Coming Acne Treatments

A recent abstract has highlighted some new acne treatments that perhaps many haven’t heard of before. As these treatments might not be on the radar for rosacea sufferers I thought it might be useful to highlight them here. Veteran rosacea sufferers will know that many acne treatments are too harsh for rosacea sufferers. Experience seems to show though, that some rosacea sufferers can tolerate …

9. Photodynamic Therapy is being used for cancer too

Photodynamic Therapy (a treatment usually consisting of a photosensitizing agent, light and tissue oxygen) is gaining popularity for its ability to treat more than just skin diseases. Internal organs and cancer sites are now being treated with PDT using endoscopes and fibre optic catheters. Even though some research papers about rosacea and PDT are available, as a rosacea treatment the usage of …

10. Suffering as bad as it gets; Erythropoietic Protoporphyria

A blog posting at Clinuvel interviews a family struggling with the severe disease Erythropoietic Protoporphyria. Parents Wendy and Ralph talk about the distress and anguish at seeing their young children suffer the pain of EPP. Also known as absolution light intolerance, Erythropoietic Protoporphyria (EPP) is caused by a build up of protoporphyrin in the skin. Exposure to the sun causes these molecules to …

11. Natural treatments may be deadly

Several Australian newspapers are running a story today about the risk that comes when people self-diagnose, self-treat and buy supplements off the shelf of a supermarket.

The whole idea of natural treatments is very appealing to many rosacea sufferers. There is certainly a group of rosacea sufferers who see prescription treatments as too artificial and too likely to cause harm. As it almost always the case …

12. Rosacea Psychology questions answered

Every so often, when we are able to solicit the help of experts, the Rosacea Support Group assembles questions that we need answered. Recently we put some questions on the psychology of rosacea to Professor Peter Drummond, Ph.D., from the School of Psychology at Murdoch University in Perth, Western Australia, and his colleague Daphne Su, D.Psych, Clinical Psychologist (Registrar) with the Department of Health …

13. Dr. Syed charged for posing as a doctor

Quite a few news sites today are covering the filing of charges of and arraignment of rosacea identity “Dr. Syed”.

Known to rosacea sufferers as Tanweer A. Syed MD. PhD, 66 year old Timothy Syed Andersson is facing 51 felony charges including practicing medicine without a license, grand …

14. Aesthera Isolaz now targets rosacea symptoms

A recent segment on ABC-TV’s Good Morning America Health featured rosacea.

One slant put on this television story was promoted by a followup press release that highlights the use of Aesthera’s Isolaz technology. In the past Aesthera’s combination of `pneumatic energy’ and broad band light has been used to treat the pustules and inflammation of acne.

most popular subscribed posts at rosacea-support.org

2010-02-09T20:09:00.001-08:00

Visitors to http://rosacea-support.org can leave comments on any of many hundreds of blog pages. When a comment is left, the visitor is able to subscribe to a post. This allows them to receive an email when the next visitor leaves a comment.

Looking at the top subscribed pages gives an idea of how popular some pages have become. Here is a list of the top subscribed pages.

how do you find cheap rosacea treatments ?

2010-02-08T18:16:00.001-08:00

So just how do you find cheap rosacea treatments ? Ask any rosacea sufferer and they will cringe when quizzed on the cost of treatments. Especially prescription treatments are scary, but even the stuff that the cosmetics counter will try to sell you will hurt your pocket.

In my quest to cut through the needless expenses here is my list of the cheapest ways to treat rosacea.

Rosacea News December 2009

2010-01-12T01:46:00.001-08:00

Rosacea News December 2009

1. Feeling depressed about rosacea ? get some help here

Does coping with rosacea sometimes get you down ? Finding good advice on how to cope with the anxiety of rosacea can be hard to find. Well now you have an opportunity to ask some questions of experts. Psychology Question and Answer session Professor Peter Drummond, Ph.D., from the School of Psychology at Murdoch University …

2. Afamelanotide continues promising results

Clinuvel is announcing more positive results with its trial of the melanin boosting drug afamelanotide for the disease polymorphic light eruption (PLE). Even though this condition is rare and it is a stretch to say that treating rosacea with this drug is a given, it is still interesting to follow the development of this drug. Today’s press release relate to the continuing …

3. Standard Management Options: according to Subtype

This paper is Part 2 in the series of Standard Management Options for Rosacea. Part 1 was devoted to the Overview and Broad Spectrum of Care. Now, Part 2 will expand to discuss management options according to the …

4. Standard Management Options: Broad Care

Authored by a who’s who of Rosacea Experts, the National Rosacea Society has again brought about a publication that puts a stake in the ground for rosacea treatment and management. …

5. What do you want to see on rosacea.org ?

The National Rosacea Society wants your input to determine what information you would like to see on their web site. As the most popular rosacea web site on the internet, rosacea.org is often the first stop for newly diagnosed …

6. Glowelle Beauty Drinks – a rosacea supplement ?

Nestle, who along with L’Oreal are the parent company of Galderma, is promoting a beauty drink called glowelle. Their buzz word rich marketing includes references to antioxidants, phyto-nutrients, botanical fruit extracts and more. The ingredients are said to fight harmful …

7. Finacea Foam being trialled

We’ve seen it with metrogel; the pharmaceutical companies want to expand the market for their existing successful products by creating followup products. A Clinical Trial is underway to test Finacea Foam for the papules and pustules of rosacea. Finacea has proved to be a good option for the `acne like’ symptoms of rosacea. Safety and Efficacy of …

8. Book Review: Rosacea: Diagnosis and Management, Frank C. Powell

Professor Frank Powell has created something quite valuable for rosacea sufferers and their physicians, an authorative and approachable medical text. Author: Frank C. Powell Review Date: December 2009 Available at Amazon.com …

9. Efracea is the UK version of Oracea

Publications filed with the UK and EU health and approval authorities suggest that Galderma is marketing the 40mg modified release doxycycline (known as Oracea in the US) as Efracea in the United Kingdom. Other member countries …

Standard Rosacea Treatment Options

2009-12-16T22:36:00.001-08:00

Lets do some quick revision. In 2002, the National Rosacea Society Expert Committee reported on a standard classification system that identified primary and secondary features of rosacea and described 4 common patterns of signs and symptoms designated as subtypes. In 2004, the committee published a standard grading system for assessing the relative severity of rosacea to enhance the utility of the classification system for researchers and clinicians.

The standard management options were developed by a consensus committee and review panel of 26 experts to assist in providing optimal patient care based on the standard classification and grading systems for rosacea that were developed to perform research; analyze results and compare data from different sources; and provide a common terminology and reference for the diagnosis, treatment, and assessment of results in clinical practice. We discuss standard management options for rosacea in 2 parts: (1) overview and broad spectrum of care, and (2) options according to subtype. The options are considered provisional and may be expanded and updated as appropriate. Managing the various potential signs and symptoms of rosacea calls for consideration of a broad spectrum of care, and a more precise selection of therapeutic options may become increasingly possible as the mechanism of action of therapies are more definitively established.

Now, see the rosacea experts thoughts on Standard Management Options 1: overview and broad spectrum of care and the Standard Management Options 2: according to subtype and while you are at it - Book Review: Rosacea Diagnosis and Management .

Rosacea News November 2009

2009-12-02T22:09:00.001-08:00

Rosacea News November 2009

1. NY Derm likes Finacea instead of Retin-A

In an ELLE Magazine December 2009 interview, New York Dermatologist Macrene Alexiades-Armenakas, MD, PhD tells us that she has rosacea. A respected and published dermatologist, Dr. Alexiades-Armenakas says that she is one of the …

2. Promiseb even better than Desonide 0.05%

Promiseb Topical Cream has been found to be as effective as desonide cream 0.05% when treating facial dermatitis. This is an exciting finding, especially if the results can be replicated at large in the rosacea / seborrheic dermatitis community. …

3. What is this mysterious Nycomed 0444 Gel ?

The Clinical Trials register has listed a just completed trial for something cryptically called 0444 Gel. The Gel is targeted for the papules and pustules of rosacea. Apparently the study started in January 2008 and has just been completed. Study of 0444 Gel in the Treatment of Inflammatory Lesions of Rosacea Sponsor: Nycomed US Inc …

4. Accutane dose of 22mg a day works best: EADV

A summary from a the recent 18th Congress of the European Academy of Dermatology and Venereology has presented some findings relating to the most effect dosage of accutane to treat rosacea. Accutane (Isotretinoin) has been successfully prescribed in …

5. Vitamin K Oxide good for purpleness after PDL

A recently published paper is proposing the use of Vitamin K Oxide (Phytonadione Epoxide Hexane) as a treatment to accelerate the recovery from the redness and purple lesions following Pulsed Dye Laser. A previous study in 1994 also found that Vitamin K cream reduced the severity of post PDL purpura. Whilst the redness and indeed purpleness that Pulsed Dye Laser treatments can …

6. DER45-EV Gel from Sol-Gel files for IND

News today that Sol-Gel Technologies has filed for Investigational New Drug for a product they are calling DED45-EV. This topical gel is targeted as a treatment for rosacea.

There doesn’t seem to be other copies of this release, or related information so this could just be a pure PR exercise.

7. Treating Rosacea with Infrared Light: Patent

A newly filed patent contains a proposed rosacea treatment using small bands of infrared radiation between 790nm and 900nm with a power between 1 and 100 mW/cm^2. The unit proposed could be a LED device, used from twice a day to every 10 days. An energy density between 3 and 180 Joules/cm^2 is proposed.

Book Review: Rosacea: Diagnosis and Management, Frank C. Powell

2009-12-02T19:02:00.001-08:00

Professor Frank Powell has created something quite valuable for rosacea sufferers and their physicians, an authorative and approachable medical text.

Author: Frank C. Powell
Review Date: December 2009
Available at Amazon.com

READ The full book review here:

Rosacea Diagnosis and Management.

Conclusion

This book gets off to an excellent start because the author is a genuine rosacea expert who is widely recognised. Professor Powell’s book is the sort of text that will see the understanding of rosacea symptoms, diagnosis and treatment increase world wide.

This book is by and far the best book on rosacea that you can get your hands on.

You can purchase the book at Amazon.com: Rosacea Diagnosis and Management.

Rosacea News October 2009

2009-11-01T18:50:00.001-08:00

Rosacea News October 2009

1. Oracea wins award for cute marketing

I can’t say that I know how much industry weight is carried by the publication Medical Marketing & Media, but they have awarded Galderma the Gold Award for `Best Individual Product Advertisement in Consumer Press’ for their …

2. Cetaphil adds UVA/UVB Defense SPF 50

Galderma announced in February a new SPF 50 Facial Sunscreen called Cetaphil UVA/UVB Defense SPF 50. Actually Galderma is not promoting this product as a sunscreen, but as a facial moisturizer. Said to be non-greasy and ..

3. Claim your Rosacea Community Blog Now !

Always wanted to have a blog or little corner of the internet you could call your own ? Well now you can. Every registered member of the Rosacea Support Community can have their very own blog area.

So please feel free to start your own Rosacea Community Blog.
Why would I want one of those ?
Your own blog will allow you post your thoughts, ideas, ..

4. IPL good for dry eyes too

WSOC-TV Charlotte, Carolina is syndicating a story about using IPL to successfully treat dry eye. Dr. Coad details how he is using IPL to treat this eye condition that is sometimes also found in ocular rosacea sufferers. Dr. Mannis in his interview for the RSRP had this to say about IPL and ocular rosacea. Q: Do you think ..

5. Topical Oxygen being trialled for sun damaged skin

A trial seeking participants interested in being treated with topically disolved oxygen (TDO) has been posted to clinicaltrials.gov. Aria Aesthetics is listed as supplying the `Aria Regimens’ in 0.5%, and 0.25%. As the trial is double blind and placebo controlled, a third group will receive no TDO during their treatments. Zoe Draelos MD is listed as a contact for the trial. Dr. Draelos ..

6. Clarisonic now available in the UK

The Daily Mail has published an article reviewing the Clarisonic in their Femail Beauty section. This article is no doubt motivated by the Clarisonic recently being launched in the UK (available exclusively via Space NK). The `oversized electric toothbrush’ is ..

7. Sansrosa starts strength tests, approaches final hurdle

In an encouraging sign that Sansrosa is slowly but surely progressing towards FDA approval, the clinicaltrials.gov register lists Galderma recruiting for a dose-finding trial for a product code named CD07805/47. The aim of this trial is show which strength is the most suitable for general use. Trial participants will be using one of 4 different strengths: 0.07%, 0.18%, %0.50 or effectively %0 contained ..

8. NRS research results explained

The NRS has just posted an easy-to-read summary of recent NRS funded research results. The update mentions the `Gallo Research’ and describes it ; “Dr. Richard Gallo at the University of California-San Diego found a consistently aberrant innate immune response in individuals with rosacea to environmental and emotional triggers.” Spin-off research related to type I interferon, plasmacytoid dendritic cells and enzyme involvement ..

9. Tetracyclines and Rosacea: what we already knew

Reading this just published abstract highlights for me just how slowly indeed research moves along. These recently proposed methods of action of tetracyclines seem to embody far from ground breaking research. We learnt in 2007 that tetracyclines have anti-inflammatory actions: “Tetracyclines are known to exhibit multiple significant anti-inflammatory actions … the mechanisms of this anti-inflammatory activity, such as inhibition of chemotaxis, granuloma formation.

Rosacea News August/September 2009

2009-10-01T01:53:00.001-07:00

Rosacea News August 2009

1. water soluble sunscreen anyone ?

An interesting looking patent application proposing a water based sunscreen for rosacea sufferers has surfaced at the USPTO. Many rosacea sufferers will know the trauma of finding a sunscreen that is gentle enough to not cause a bad reaction and effective enough to protect from the harm of the sun. For me the sun has always been my worst trigger. Certainly physical sunscreens …

2. so does acupuncture work, or not ?

For me acupuncture has always been part of some kind of ancient mythology. Humans are controlled by a brain that has complex neurological pathways to all corners of their bodies. Can inserting fine needles in to the so-called meridians along energy …

3. Epsom salts or Milk of Magnesia actually works ?

A few newspapers have picked up this Question & Answer article where rosacea sufferers are encouraged to try Epsom salts (magnesium sulfate) or Milk of Magnesia on their skin.

One can imagine that a bath with Epsom salts would be relaxing, but …

4. Sebclair launches as Promiseb Cream

I was alerted to the launch of a product called Promiseb by a comment left on the Sebclair for Seborrheic Dermatitis post. Since then the news web sites are also covering the press release. Promiseb (probably pronounced Promi-seb) is launching in the U.S. via Promius Pharma, after being licensed from Sinclair Pharma in 2007….

Rosacea News September 2009

1. Oracea worth $104m a year, good news for Sansrosa

According to a press release via Reuters, sales of Oracea were approximately $104 million for the twelve-month period ending July 2009. This figure is up almost 200% from the previously reported sales of $52.5 million in …

2. Impax Laboratories joins the generic Oracea battle

September 21st, 2009, by Digital Davo | oracea, patents | Edit

In a further confirmation that the low dose doxycycline market is a becoming a fighting ground, a recent press release states that Impax Laboratories has filed “Abbreviated New Drug Application ("ANDA") containing a paragraph IV certification for a generic version of ORACEA with the U.S. Food & Drug Administration ("FDA").” This is a challenge to the patents held by Galderma, relating …

3. PSF reduces the pain of Pulsed Dye Laser

This just published abstract from Lasers in Medical Science, shows that the extreme pain associated with pulsed dye laser, when used to treat port wine stains, can be relieved by using Pneumatic Skin Flattening (PSF). Pneumatic Skin Flattening uses a vacuum to compress the skin underneath the area being treated. Blood is eliminated from the treatment area. The technique is said …

4. FDA gets tough with Aczone

The FDA has issued a warning letter to Allergan, the makers of Aczone for overstating the efficacy of Aczone and also for understating the possible side effects. In a sign that the FDA is watching carefully the claims that vendors use when advertising their products, the warning letter calls out a journal advertisement for Aczone as violating the Federal Food, Drug, and Cosmetic Act. …

Rosacea News August 2009

2009-08-31T19:13:00.001-07:00

Rosacea News August 2009

1. water soluble sunscreen anyone ?

2. so does acupuncture work, or not ?

3. Epsom salts or Milk of Magnesia actually works ?

A few newspapers have picked up this Question & Answer article where rosacea sufferers are encouraged to try Epsom salts (magnesium sulfate) or Milk of Magnesia on their skin.

One can imagine that a bath with Epsom salts would be relaxing, but …

4. Sebclair launches as Promiseb Cream

I was alerted to the launch of a product called Promiseb by a comment left on the Sebclair for Seborrheic Dermatitis post. Since then the news web sites are also covering the press release.

Rosacea News July 2009

2009-08-10T00:01:00.001-07:00

Rosacea News July 2009

1. Doxium being trialled as Pulsed Dye Laser adjunct

A new trial is recruiting participants to evaluate the use of calcium dobelisate as a combination therapy, along with Pulse Dye Laser to treat the erythema, flushing and telangectasia associated with erythematotelangietatic rosacea. We know from rosacea and doxium that “Calcium dobesilate is a vasoactive drug with presumed effects on endothelial integrity, capillary permeability and blood viscosity.” Clinical Trial …

2. Calling all Rosacea Researchers: get your grants now !

The National Rosacea Society is calling for grant applications for their 2010 allocation. Good to see that they want an emphasis on research into the cause rosacea. From New Grants Available Monday, July 27, 2009 New grants are available from the National Rosacea Society (NRS) to support research on potential causes and other …

3. Abstracts: Elidel, Bacteria & Ocular prevalence

The following abstracts don’t deserve a Rosacea News item on their own, but are interesting enough to give a mention here in this Abstract Roundup. Elidel no better than Metrogel for lumps and bumps of rosacea. A comparison of metronidazole 1% cream and pimecrolimus 1% cream in the treatment of patients with papulopustular rosacea: a randomized open-label clinical trial. Clin Exp Dermatol. 2009 …

4. Sol-Gel Trialling Benzoyl Peroxide (DER 45 EV) for Rosacea ?

An intriguing Clinical Trial has been listed on the ClinicalTrials.gov web site. The product know only as DER 45 EV Gel (in strengths of 1% and 5%) has been listed in a dose-range trial for the papules and pustules of rosacea. Clinical Trial NCT00940992, A Dose-Range of DER 45-EV in Treatment of Rosacea (SGT-EBPO1-09) …

5. we’ve all been exposed to demodex bacteria proteins ?

An article published today in the Irish Times takes one more step in the direction of showing an association between demodex mites and rosacea. Readers of Rosacea News will know that a lot of research has tried to find a causative link between the presence of demodex mites and rosacea symptoms. Some progress towards a link between the two was …

6. acupuncture, yoga, hat and moisturiser says Daily Mail

We are seeing more and more newspaper health and beauty articles that relate to rosacea. Today the UK’s MailOnline has an intriguingly titled article – How waggling my feet has helped my red face. To save you …

7. accutane and drinking alcohol – no problem, apparently

This just published abstract is suggesting that it appears to be safe to consume alcohol while taking accutane. Whilst the Accutane Prescribing Information does not prohibit the consumption of alcohol, it does suggest that alcohol …

8. CeraVe Hydrating Cleanser and CeraVe Moisturizing Lotion User Reviews

Recently the manufacturers of Finacea, Intendis, and Coria Laboratories, have begun promoting a new combination package it is calling Finacea plus. This package encourages rosacea sufferers to combine a tube of Finacea with CeraVe Hydrating …

9. Restasis (cyclosporine) as ocular rosacea treatment

It is good to see more published research backing topical cyclosporine (Restasis, Allergan) as a treatment for ocular rosacea. Restasis (cyclosporine ophthalmic emulsion 0.05%) has been shown to increase tear production and improve the quality of naturally produced tears and is …

Rosadyn Vasculokinetic and Skin Health Support

2009-07-06T21:06:00.001-07:00

The Rosadyn site is full of scientific terminology.

Addresses all symptoms of Rosacea: Facial Redness and flushing skin inflammation and sensitivity inflammatory bumps and breakouts.

Advanced non-prescription oral nutraceutical for vascular, ocular and skin support

Targets the root precursors of facial redness, inflammation and flushing.

Developed by Dr. Geoffrey Nase PhD., Rosacea Specialist and Researcher.

Further claims about Rosadyn: advanced pharmaceutical-grade nutraceutical, vasculokinetic, Absorption Enhancement Blend, Hypothalamus Support, Hypothalamic overdrive.

Rosacea News June 2009

2009-06-29T19:01:00.001-07:00

Rosacea News June 2009

1. doryx + applesauce, for those who can’t swallow tablets

If you have trouble swallowing tablets, here is an official FDA sanctioned tip. Open the tablet and sprinkle the delayed release pellets on to a spoonful of applesauce. This is a good option for anyone who finds swallowing the …

2. NYTimes says no natural remedies for rosacea

The New York Times has an article today keenly titled Natural Remedies for Rosacea?. The question is one that many rosacea sufferer seek answered – are there any effective treatments for rosacea that don’t include the use of antibiotics or prescription potions and lotions ? The answer comes from one of the premier rosacea experts – Dr. Frank C. Powell. Here is an extract …

3. Favourite Over The Counter treatments

Do you have a favourite over the counter treatment for your rosacea ? Depending on your health insurance and access to doctors and pharmacies, prescription treatments are out of the reach of many rosacea sufferers. So what can you try as a rosacea treatment that is easy to source, cheap and …

4. Vita-Oil Release Next Week. Tinted ZincO in July

Here is an announcement from RosaceaCare: “Earlier this year, we announced that four important and popular rosacea products that had been unavailable for many months would thereafter, by special arrangement with the originator, be manufactured and distributed by the Rosacea Care Company. We are pleased to tell you that the first of these, the much-loved Vita-Oil, will be released and ready to ship this …

5. Is Oracea different to 50mg doxycycline ?

I came across the following graph in a recent presentation at the recent AAD meeting and figured it was interesting enough to highlight it here. The following graph, sourced from Collagenex (who sell Oracea), shows the blood plasma concentration of doxycycline after taking Oracea compared to 50mg once a day of generic doxycycline. The horizontal axis stretches out to 24 hours post dosage. …

6. Doxium (calcium dobesilate) trialists wanted

Thanks to a comment from Sophie on the post rosacea and doxium (calcium dobesilate) we know that Dr. Cuevas who is responsible for several papers on Dobesilate, is accepting people to try it as a treatment for rosacea. Thanks for the info Sophie.

7. Green Tea helps after IPL

This just published paper is suggesting that the topical application of polyphenol antioxidants (aka green tea) post IPL treatment resulted in more hydrated skin and reduced oxidative degradation of skin lipids. The authors suggest that this will enhance the effects of the IPL therapy.

Common Rosacea Mis spellings

2009-06-16T05:02:00.001-07:00

One of the things about rosacea is that it is, well kinda spelled weird like. You can easily misspell it – especially if you hear it said, your chance of writing it correctly are pretty low.

So here we go – the most popular mis-spellings of rosacea, according to the google keywords tool ;

I’m sure you’ll see some more in your travels too.

Rosacea News May 2009

2009-06-01T20:07:00.001-07:00

Rosacea News May 2009

1. Dermatology Times highlights Afrin and Sansrosa

The Dermatology Times is running an article highlighting the novel and unlikely rosacea treatments based on a nasal decongestant and a glaucoma treatment. They of course are referring to Oxymetazoline and Brimonidine. The article mentions the positive results from the “most recent research” on Brimonidine ; In the most recent research, a double-blind study for Galderma, a 1 g application …

2. Ocular rosacea: oligosaccharide based treatments

An interesting looking patent that was filed in 2006 has come up as reaching filed status. This patent covers the relationship between an oligosaccharide specific to an inflammatory disease, more specifically ocular rosacea. The discovery may lead to both a definitive diagnostic test and new treatments for ocular rosacea. One of inventors of this patent is well known to rosacea sufferers. Dr. Mark Mannis …

3. Oracea too expensive ?

Some interesting comments from KUNC commentator Dr. Marc Ringel via a NPR segment. He raises two points that are worth discussing. Firstly is Oracea really any better than generic doxycycline and secondly what does it say about the pharmaceutical industry (and insurance companies – ed) that a repackaged old product can be so expensive ? Galderma would say that Oracea is sub-antimicrobial …

4. would you like an electric current with your topical ?

A couple of recently awarded patents look both interesting and slightly scary for potential rosacea treatments. These patents cover some kind of device that is stuck to the skin. A small electric charge is used to help an active chemical cross the skin barrier. Some kind of carrier (an electrolyte) allows Zinc ions to flow between the electrodes, across the skin, creating a small charge. …

5. LED post laser helps recover from redness

A recent abstract from Dermatologic Surgery suggests that treatment with 590nm LED therapy following fractional laser skin resurfacing helps patients more quickly recover from the post treatment erythema. Whilst skin resurfacing with a laser is considered dangerous for rosacea sufferers, the fact that LED therapy help speed up recovery is good news for LED and low level light therapy in general. The study showed that …

6. novel tetracycline from Warner Chilcott and Paratek

Some very preliminary internet crumbs about a new possible rosacea treatment under development. The treatment under development is listed as a “novel tetracycline”. Warner Chilcott Limited calls itself a “specialty pharmaceutical company, that engages in the development, manufacture, marketing, and sale of branded prescription pharmaceutical products in women’s healthcare and dermatology segments primarily in the United States”. In the WCRX 2007 Annual …

7. Botox for neural symptoms and flushing, user reviews

Some interesting discussions from both experts and users of botox treatments for rosacea have are emerging online and are worth reviewing. A quick search on Google shows that several clinics are now offering botox as part of their rosacea treatments. Better known for it’s cosmetic use, the highly toxic protein known …

8. Glyco Mira developing anti-cathelicidin treatment ?

A brief paragraph in a recent article in The Salt Lake Tribune looks quite interesting. A company called Glyco Mira (seemingly a company without a web site) is developing a drug that “may be able to cure the underlying problem that causes rosacea”. A pretty tall prediction for sure. So what are they talking about ? Glyco Mira have licensed and anti-inflammatory drug from the …

Rosacea News April 2009

2009-05-03T21:33:00.001-07:00

Rosacea News April 2009

1. Pyratine XR launches, user reviews

fact sheets, in the news, kinerase, moisturizers, topicals, user reviews

Showing just how important the internet is becoming for marketing new cosmetics, Pyratine XR has recently launched with a lot of press activity. As well as Senetek’s press releases on the internet I was also contacted by 2 …

2. Video Tips from Rosacea Rescue Squad

in the news

The Galderma rosacea promotional site Best Face Forward has a new section titled Rosacea Rescue Squad. The site features some video tips from Dr. Hilary Baldwin and Charla Krupp. Dr. Baldwin, who is a dermatologist from …

3. moisturize before or after finacea - it doesn’t matter

finacea, moisturizers, topicals

Well here you are, one of the frequently asked questions about rosacea topicals has been answered. Does it matter whether I apply my rosacea prescription topical before or after I use a moisturizer ? This recently available abstract suggests that in fact it doesn’t matter. The study looked at the absorption of finacea before and after moisturizer lotions were applied and was unable …

4. GlaxoSmithKline to buy Stiefel (Rosac/Rosasol)

in the news, topicals

Continuing recent consolidations in the pharmaceutical industry is the report that the giant GlaxoSmithKline (or GSK) are to purchase Stiefel. Stiefel is the manufacturer of …

5. AAD: oxymetazoline, dapsone and light therapy

in the news

As promised in my 67th AAD Meeting SFO, rosacea highlights news item, here are some updates from the conference proceedings and handouts. In this update we’ll look at how Dr. Downie mentions the new and future possible treatments for rosacea. This is encouraging, to see dermatologists discussing what is new and potentially interesting in the field of rosacea. SYM S048, Treatment …

6. AAD: off-label and future rosacea treatments

in the news

As promised in my 67th AAD Meeting SFO, rosacea highlights news item, here are some updates from the conference proceedings and handouts. In this update we’ll look at a couple of slides from Dr. Thiboutot.

Rosacea News March 2009

2009-03-30T05:17:00.001-07:00

Rosacea News March 2009

1. ZENMED User Reviews

Those who have been around on the internet for a while won’t have failed to notice ZENMED. ZENMED (they use all capitals) are good at advertising and have a high profile through their advertising campaigns. In fact because Zenmed use Google Adwords you can sometimes see advertisements for them here on rosacea-support.org. When you have a company that you don’t know much about, but has …

2. AAD: natural ingredients have a role in rosacea therapy

As promised in my 67th AAD Meeting SFO, rosacea highlights news item, here are some updates from the conference proceedings and handouts. In this update we’ll look at how Dr. Downie suggests that natural ingredients do have a role in the treatment of rosacea. It is encouraging to see these complementary ingredients feverfew, green tea and licorice getting some mainstream …

3. IPL pain and no gain: Telegraph Health & Well Being

The UK newspaper The Daily Telegraph has a short fluff piece on IPL. As is usually the case with this style of article there is little substance. The reporter was not impressed with the results but was impressed with the pain and bruising and swelling. Intense Pulsed Light (IPL): miracle cure or waste of money? It is …

4. Galderma suing Mylan Pharmaceuticals over Oracea

Galderma, the makers of Oracea are suing Mylan Pharmaceuticals for allegedly infringing 4 patents related to their sub-antimicrobiotic dose doxycycline product Oracea. State University of New York, Galderma Sue Mylan March 20 (Bloomberg) — The State University of New York, Galderma Laboratories LP and New York University sued generic- drug maker Mylan Pharmaceuticals Inc. for allegedly …

5. Sun linked to rosacea, but which came first ?

The NRS have an entry up on their weblog discussing the link between sunburn and rosacea. A study of 65 healthy subjects and 65 moderate to severe rosacea sufferers found that the rosacea patients `had significantly higher rates of blistering sunburns that those without rosacea’. Sadly there was no conclusion as to whether the extra incidence of sunburn contributed to the severity of …

6. Sansrosa composition revealed in patent application

A new sansrosa patent application has appeared, and from it was can see clearly what formula will be used for the sansrosa gel and sansrosa cream formulations. We don’t know the official name for the product yet, but it seems to make sense to me to call the product Sansrosa Gel and Sansrosa Cream.

Those following the development of sansrosa closely will be encouraged by this …

7. Rosacea Expert Series: IPL & Laser

Continuing our Rosacea Expert series, the Rosacea Support Resource Pages now has a summary of the ongoing Ask a Doctor IPL & Laser sub-forum. Have a read of Laser & IPL: Dr. Peter Crouch, MB.BS, Dr Steve Johnson, MD, Dr. Nicholas Soldo, MD to find out more about the following questions; ACCUTANE WITH RED LIGHT …

8. ho hum: finacea + oracea vs. metrogel 1% + oracea

The Clinical Trials register has listed a new trial for papulopustular rosacea. The trial, sponsored by Intendis, the manufacturer of Finacea, wants to compare the combination of Oracea and Finacea, with the combination of Oracea and Metrogel 1%. It seems clear from this that Intendis would like to position Finacea as a viable alternative to Metrogel. This makes good sense …

9. 67th AAD Meeting SFO, rosacea highlights

The 67th Annual Meeting of the American Academy of Dermatology is due to meet this week in San Francisco. I have to say that the AM09 Program looks a little uninteresting for those following rosacea developments. The program contains a few advertisements from Finacea, the new Instant Relief Mineral Powder from the Clinique Redness solutions range and also Aczone …

Rosacea News February 2009

2009-02-27T00:17:00.001-08:00

Rosacea News February 2009

1. NRS Awards 2009 Research Grants

The National Rosacea Society have just announced their 2009 research grants. Four studies have been chosen, totally almost $90,000. Quite a buzz for me to see that a study in Australia has made the grade. Dr. Richard Gallo, who has received a lot of press coverage from the research on the role of cathelicidins, and …

2. Tropisetron (Navoban): rosacea patent filed by Galderma

My regular patent trolling has unearthed something potentially interesting. The anti-nausea drug Tropisetron is patented by Galderma as a treatment for inflammatory skin conditions including rosacea. Tropisetron is officially known as a 5-HT3 receptor antagonist or a serotonin antagonist. Serotonin (5-HT) is found widely distributed throughout the gut and the central nervous system ADMINISTRATION OF TROPISETRON FOR TREATING INFLAMMATORY SKIN …

3. seborrheic dermatitis: state of the art, finacea 3 stars

This paper summarises the current state of the art for seborrheic dermatitis – research and treatment options. The author mentions recent research that links seborrheic dermatitis with a spore known as Malassezia Globosa. He makes the point that azelaic …

4. ZincO, Vita-Oil and Oatmeal Cleanser available again soon

Following is an announcement from Rosacea Care. EXCITING NEWS We have just received word that four products that have been important to many rosacea sufferers will be available again later this spring. By arrangement with the originator of these products, the Rosacea Care Company will be manufacturing and distributing ZincO, Tinted ZincO, …

5. L’Oréal strong sales via Galderma and dermatology

L’Oréal has just posted its 2008 Annual Results. The results show that L’Oréal has had a good year, mostly because of the excellent performance of Galderma. It may come as a surprise to many to know that Galderma, the …

6. Sebclair / Atopiclair available in Australia

It looks like Australians can easily get this preparation via mail and pay via paypal.

It appears to be called Atopiclair and is available from
http://www.atopiclair.com.au/ It is listed as Atopiclair Cream 40ml and is $49 including postage to anywhere in Australia.

7. Vectical (topical Vitamin D3) approved for Psoriasis

The FDA has recently approvedVectical (topcial vitamin D3 from Galderma) for the treatment of plaque psoriasis. The active ingredient of Vectical is known as calcitrol and is a naturally occurring form of vitamin D3. Calcitrol has been shown safe to use for extended periods up to 52 weeks and also on sensitive skin fold areas. Users of Vectical should avoid exposure to the sun.

Rosacea News January 2009

2009-02-04T03:31:00.001-08:00

1. Top 5 ways to save money treating rosacea

Distressed with the expense of exotic rosacea treatments ? The stress of rosacea is enough without also having to worry about how to afford treatments. Finding affordable rosacea treatments is a real challenge. Here are my top 5 suggestions for …

2. afamelanotide positive Phase III results for erythropoietic protoporphyria

Clinuvel has announced positive interim Phase III results from the first of the trialists to complete a 12 month study in Switzerland. The 14 patients in Switzerland will form part of 101 to undergo long term study around the world. Further participants and …

3. do naturopathic treatments work for rosacea ?

What are the best known naturopathic treatments for rosacea, and how well have they been shown to work ? Naturopathy is a medical philosophy that tries to improve our health by helping the body’s own ability to recover from illness …

4. Medicis readies to trial Ziana for rosacea

Just posted on the clinicaltrials.gov database is an entry “Safety and Efficacy Study of Clindamycin Phosphate 1.2% and Tretinoin 0.025% Gel to Treat Rosacea”. This topical product, known as Ziana, is currently approved for the treatment of acne.

5. Sansrosa has neuro protective properties

We know from patent filings that the active ingredient in the in-development sansrosa product is brimonidine tartrate. This is also the active ingredient in Alphagan P, a treatment for glaucoma.

Alphagan P 0.1%, is known as an alpha2-adrenergic receptor agonist, and is used to lower intraocular pressure and reduce ocular hypertension. Around 10-20% of users of Alphagan P experience adverse side …

6. Vote for your most wanted Linda Sy product

Good news for those wanting to be able to purchase Linda Sy products again. There is some possibility that a selection of her rosacea products will be sold through another online skin care provider.

7. Rosacea Support: 2008 the year that was

Time for some end of year statistics – for those who like that sort of thing.

Before we kick off just a note. The most important thing is that thousands of people have found useful information about rosacea. May this continue to be the case into 2009.

Top 5 ways to save money treating rosacea

2009-01-29T18:04:00.001-08:00

Do you have any recommendations for your fellow rosacea sufferers that are on a budget ?

cetaphil gentle skin cleanser well tolerated
cetaphil moisturizing cream helps rosacea dry skin
Prosacea User Reviews
generic metrogel soon – Fougera
Rosacea Support Community: Homemade Mixes
RSRP: Custom Topical Formulations

Rosacea News December 2008

2009-01-06T17:28:00.001-08:00

Rosacea News December 2008

1. Epidermal Growth Factor (EGF) patent application published

Artist has mentioned in the past that she has been associated with a patent to do with treating rosacea. Her involvement with SkinActives led her to investigate using Epidermal Growth Factor (EGF) to treat rosacea. The success she experienced led SkinActives to subsequently file a patent. This patent has now reached the application status and can be viewed at the USPTO web site

2. BHA, veinwave, human placenta cream gets plugged by The Times

The UK newspaper The Times has a plug for veinwave, human placenta treatments and beta hydroxy acid for treating rosacea. This article is an update to a previous article also featuring rosacea sufferer Allie Todd. The January 26 article was …

3. Dry Eye Syndrome from Sunday Times Sri Lanka

The Sunday Times in Colombo has a recent article devoted to Dry Eye Syndrome titled Looking through a dry lens, an interview with Consultant Ophthalmologist Dr. Charith Fonseka from the Eye Hospital in Colombo. "Dry eye syndrome is usually due to a problem with the quantity …

4. MJF and Parkinson’s disease: if only rosacea had such a benefactor

A really interesting piece in the New York Times about how Michael J Fox is the front man for a revolutionary foundation fighting Parkinson’s Disease. The Michael J. Fox Foundation for Parkinson’s Research has funded an amazing $125m in research. From Taking Science Personally; What makes the story of the Michael J. Fox Foundation different — nay, what makes …

5. OCuSOFT Lid Scrub Plus kills demodex mites. Really ?

Here is a good example of why not to believe everything you read on the internet. Today the internet news stream has a `release’ titled OCuSOFT(R) Lid Scrub(TM) PLUS Proven to Kill Demodex Mites. In …

6. treating rhinophyma (large swollen nose) with ER:YAG Laser

Did you know that the first known rhinophyma surgery was performed by Daniel Sennert in 1629 ? Were you also aware that the proven link between rosacea and rhinophyma was established in 1846 ? Rhinophyma and rosacea sure have …

Rosacea Support: 2008 the year that was

2008-12-31T23:54:00.001-08:00

Rosacea Support Blog

Time for some end of year statistics – for those who like that sort of thing.

Before we kick off just a note. The most important thing is that thousands of people have found useful information about rosacea. May this continue to be the case into 2009.

Unique Visitors to rosacea-support.org: 489,098

Page Views on rosacea-support.org: 1,682,675

Blog Posts and Pages: 375

Comments left on Blog: 1012

Top 5 Blog Pages:

Rosacea Support Resource Pages

Unique Visitors to Rosacea Support Resource Pages: 41,921

Page Views on Rosacea Support Resource Pages: 95,585

Rosacea Support Email Group

Emails posted to rosacea-support@yahoogroups.com: 3842

Rosacea Support Community Forum

Messages posted to Rosacea Support Community: 5,015

I wish everyone a great 2009. May this year be one that you look back on with fondness and with satisfaction at moving forward in your life.

warmest regards,

David Pascoe.

Rosacea News November 2008

2008-12-01T00:04:00.001-08:00

1. are you a cyberchondriac ? the dangers of the internet

Self diagnosis using search engines can lead to internet users concluding the worst about their ailments. So says some recent research from Microsoft. The researchers looked at health related web searches and also surveyed employees of Microsoft. This study is thought to be the first systematic look at the anxiety of people doing web searches related to health care. A couple of the examples …

2. IPL burns from `Top London Spa’

The Independent newspaper in the UK has an article today in their Health & Wellbeing section detailing (seemingly) a reporter who was badly burned by an IPL treatment. The photos show large uneven red welts on her chest and areas of redness on her face also. The initial treatment was carried out by …

3. RosaceaCare Cool Relief Mask Samples available

The guys at RosaceaCare have sent me some samples of their new Cool Relief Facial Mask. Their web site promotes this product as a cooling mask that “contains many of the ingredients that have proven so successful in our other products: Willowherb Extract, Green Tea Leaf Extract, Jojoba Seed Oil, Allantoin and …

4. cinnamon supplements may make rosacea much worse

Apparently cinnamon oil supplements are commonly used by sufferers of type 2 diabetes to reduce their blood sugar and cholesterol levels. One study from Pakistan concluded that cinnamon taken at 1, 3, or 6 gm daily significantly decreased the …

5. UK Warns about Melanotan usage

The mainstream UK press has several articles today about the risks of an using a yet to be approved injectible tan, even go so far as to name Melanotan. The Independent: Warnings over ‘injectable tan’ product People seeking a glow this winter should avoid an "injectable tan" being sold illegally, regulators warned today. The Medicines …

6. How to cure a red swollen nose

7. DermatologyTimes on LED and IPL Combination Therapy

From the Nov 1, 2008 edition of DermatologyTimes; Synergistic effect: Combining LED devices with PDL or IPL optimizes rosacea treatment Combination laser and light-based treatments for rosacea have a synergistic effect and are now being studied, according to David J. Goldberg, M.D., a board-certified dermatologist in practice since 1985 at Skin Laser & Surgery Specialists of New York and …

8. DermatologyTimes: Sansrosa not available for several years

Dermatology times has posted some short items that may be worth reading. Most of these topics are not new to regular readers of Rosacea News, but it is good to see at least some others covering them as well. One article talks about how Galderma/Collagenex is excited about new possible drugs. It doesn’t directly name the Sansrosa product, but it does have a …

Rosacea News September + October 2008

2008-11-16T18:06:00.001-08:00

1. lindasy.com is closing down

Just in case anyone has missed the email over at rosacea-support; Linda Sy has been in contact to say that she is retiring and thus her web site and business is closing. Anyone who wants to stock up on their favourite products will need to order some now as they will no longer be available after the end of October, or as long as stock lasts.

2. contact lenses and ocular rosacea, tips and advice

The NRS Ask the Doctors blog section has a post up today with some advice about ocular rosacea and using contact lenses.

`What guidelines should I follow regarding contacts if I have ocular rosacea? Response by Dr. Marian Macsai, vice chairman of ophthalmology at Northwestern University.’

3. how to reduce your visible pore size: NRS Blog

The NRS Ask the Doctors has a new post up asking Rosacea has made the pores on my face large. When I get my rosacea under control, will my pores return to their normal size? Topical and oral antibiotic therapy may be prescribed for mild cases, but more severe cases may sometimes be treated with isotretinoin, which is an …

4. NRS acknowledges children can get rosacea

The latest instalment of the NRS Ask the Doctors blog addresses the possibility of children suffering from rosacea. Dr. Paller says that the published literature does mention cases of rosacea being found in children, although it is rare. The possibility of childhood ocular rosacea is also mentioned. My wife believes that our 10-year-old son might have rosacea. She is a sufferer, and …

5. Photoprotection expertise from Clinuvel

Perhaps Clinuvel is best known as the Australian company that is developing Afamelanotide. As some background: Melanotan is the proprietary name for afamelanotide (CUV1647) which is being development by Clinuvel Pharmaceuticals. Afamelanotide has been designated by the world health organisation as the International Nonproprietary Name for the melanocyte stimulating hormone under development by Clinuvel. Clinuvel is promoting this drug as a …

6. NRS on seborrheic dermatitis

The National Rosacea Society web site has just uploaded a page on Seborrheic Dermatitis ; Although the two disorders are unrelated, a recent clinical study found that 26 percent of patients with rosacea also had facial seborrheic dermatitis and 28 percent had seborrheic dermatitis of the scalp. Additionally, a survey by the National Rosacea Society of 1,100 rosacea patients found …

the red nose of rosacea

2008-11-12T21:55:00.001-08:00

The red swollen nose of rosacea is a much hated symptom. I know that this was the symptom that I despised most and indeed drove me 10 years ago to start to look for good information about how to treat rosacea. Incidentally, this drive lead to the creation of the internet based Rosacea Support Group in 1998.

Here are my notes on how to cure a red swollen nose

Rosacea News August 2008

2008-08-29T00:20:00.001-07:00

1. Handheld OMNILUX clear-U, red and blue LEDs together

Blue light in combination with red light has been shown to be effective in the treatment of acne. It has been proposed that the 2 colours act together synergistically to combine their antibacterial and anti-inflammatory actions. This paper looks at the handheld unit called the Omnilux clear-U (from Photo Therapeutics). This unit has a flat plane measuring, 60mm x 50mm, consisting of LEDs emitting light at wavelengths of blue light; 415nm (at 40mW/cm2) and red light; 633nm (at 70mw/cm2). The unit allows you to switch between the red and blue modes of operation.

2. topical vitamins A, C, E and B3

Vitamins A,C, E & B3 are found naturally in the skin and have been shown to have potent anti-inflammatory and anti-oxidant properties. They can be depleted by sunlight, smoking, pollution and other free radical stress. The number of products containing these vitamins has ballooned in recent years. Read on to see how the theory and background of these Vitamins might be good for you.

3. natural anti-inflammatory therapies

Dr. Wu published a paper in 2006 on treating rosacea with herbs. This paper highlighted the properties and potential rosacea treatment modalities of licorice, feverfew, green tea, oatmeal, lavender, chamomile, tea tree oil and camphor oil. This just published paper concentrates more on the anti-inflammatory properties of several natural products and reviews the evidence supporting their use in inflammatory skin conditions.

4. colloidal oatmeal: a dream ingredient for rosacea sufferers

Colloidal Oatmeal is a versatile and multi-functional compound. This paper details the history and chemistry of colloidal oatmeal and shows how its’ chemical polymorphism leads to many useful clinical properties. Of most interest to rosacea sufferers are the cleansing, moisturizing, buffering, soothing, protecting and anti-inflammatory properties. Colloidal Oatmeal may well be the dream ingredient for rosacea friendly products.

5. oxymetazoline may be good for 2 years

The dermatology news sheet Dermatology Times has published an item to their web site about the emerging use of oxymetazoline to treat the redness and flushing associated with rosacea. This article draws from the Nov. 2007 paper that introduced us to the possibility of treating rosacea with oxymetazoline.

6. just how do you kill demodex mites ?

Demodex mites and rosacea seem to be a popular pairing. If you are interested in eliminating demodex mites to see if your rosacea symptoms improve, just how can you kill them ? Demodex mites are tiny, and live naturally in everyone’s skin. They are quite difficult to kill. Read on if you’d like to know more.

natural anti-inflammatory therapies

2008-08-24T22:14:00.001-07:00

Many rosacea sufferers want to treat their symptoms with natural therapies. This pursuit can be tricky as many natural ingredients are not easily obtained in a useable form. In the end it is sometimes just down to using commercial preparations that contain the active ingredient – and hopefully at the same time no other potentially irritating components. Another option is to try natural ingredients using a homemade mix.

Find out more about turmeric, colloidal oatmeal, feverfew, licorice, chamomile, and aloe vera in the natural anti-inflammatory therapies article.

colloidal oatmeal: a dream ingredient for rosacea sufferers

2008-08-15T00:24:00.001-07:00

oxymetazoline may be good for 2 years

2008-08-13T18:36:00.001-07:00

The dermatology news sheet Dermatology Times has published an item to their web site about the emerging use of oxymetazoline to treat the redness and flushing associated with rosacea. This article draws from the Nov. 2007 paper that introduced us to the possibility of treating rosacea with oxymetazoline.

Oxymetazoline is classified as a alpha-1 Adregenic Receptor Agonist, whereas COL-118/Sansrosa is a alpha-2 Adregenic Receptor Agonist. According to this DT article oxymetazoline is “also partially selective for the alpha 2a receptor.”

(click to read more about oxymetazoline may be good for 2 years )

Afamelanotide (Clinuvel CUV1647) gets orphan drug status in the US

2008-08-10T17:54:00.001-07:00

Afamelanotide (Clinuvel CUV1647) gets orphan drug status in the US

Clinuvel Pharmaceuticals has announced that they have been granted orphan-drug status by the FDA to treat the skin condition erythropoietic porphyrias. Orphan drug status is granted to new drugs that treat rare conditions and is used as an instrument to obtain accelerated review by the FDA. The FDA allows tax reductions and market exclusivity for orphan drugs to encourage otherwise un-profitable drugs targeting rare conditions to be developed.

Rosacea News July 2008

2008-07-30T23:42:00.001-07:00

1. Afamelanotide (Clinuvel CUV1647) gets orphan drug status in the US

2. EC approves Oracea for sale in Europe

The news sites are buzzing with the announcement that the European Commision has granted marketing authority for Oracea. The first domestic approvals for Oracea will be granted in Germany, UK, Italy, Austria, Ireland, Sweden, Finland, Luxembourg, and the Netherlands. MediGene has the rights to sell Oracea throughout Europe. Local approvals are expected within 30 days. This news follows on from the announcement …

3. rosacea allergic reaction to Vitamin K & Vitamin E

This paper raises and interesting topic. The researchers were able to prove that 3 rosacea sufferers were allergic to alpha-tocopherol (Vitamin E) and Vitamin K. By eliminating the components of the creams they were using, they were able to isolate the individual components that were causing the allergy. Rosacea sufferers can become attuned to the ingredient listing in cosmetics, scouring the list to find something …

4. AARS publish their rosacea treatment guidelines

The American Acne & Rosacea Society have published a PDF containing their Rosacea Medical Management Guidelines. The aim of the guidelines is “to provide an overview of the fundamental disease state of rosacea and quality of life implications and outline available pharmacological …

5. rosacea sufferers have more anxiety and depression

In the past there hasn’t been a lot of research into the relationship between rosacea and mental health. Many rosacea sufferers know that there is a strong relationship between their symptoms and how they feel about themselves. This abstract mentions some research comparing rosacea sufferers with people without any facial lesions. They found that the rosacea sufferers had several psychological problems not found …

6. demodex bacteria, one baby step at a time

Some recent NRS supported research has made more steps towards showing a possible link between demodex mites and rosacea symptoms. Although this Br J Dermatol paper was mentioned by Rosacea News in (see demodex mite bacteria causes the inflammation ?) June last year, I just got hold of the full text this week.

Rosacea News June 2008

2008-06-29T22:57:00.001-07:00

Rosacea News June 2008

1. rosacea sufferers less interested in alternative medicine

According to this recently published short correspondence, rosacea sufferers are much less likely to use complementary and alternative medicine compared to sufferers of psoriasis and other dermatological conditions. Whilst the reason is not clear, it appears one reason could be that sufferers are happy with the efficacy of their current treatment. The majority of patients felt that the complementary and alternative therapies were less helpful …

2. sensitive skin on your hands, feet and scalp too ?

The common wisdom about rosacea is that is only occurs around the flush zones on your face. A recent paper challenged this idea with a case study of a patient who had rosacea lesions on his arm, and upper chest area. Another related recent short paper titled Sensitive skin is not limited to the face, that has the conclusion that sensitive skin is …

3. NRS wants your feedback on Research !

The NRS Blog has a new entry today where they are asking for your feedback on the direction of future rosacea research. The NRS have put their Reader Survey (part of their Rosacea Review publication) online for the first time.

4. Allergan buys Aczone, has plans for rosacea targeting ?

OK this story is getting so much coverage in the online press that I thought I should cover it here too. Allergan is buying the topical dapsone product called Aczone for $150m. From: Allergan Announces Agreement to Acquire Aczone(R) Gel 5% …

5. Sansrosa gel vs. eyes drops absorption trial details posted

The Clinical Trial register is showing details for the bio-availabilty trial for COL-118/Sansrosa. This Phase 2 trial aims to compare the amount of the active ingredient that is bio-available when the newly formulated gel is used on rosacea skin, and when used as eye drops.

This announcement appears to be the extra trial asked for by the FDA who are concerned that …

Rosacea News May 2008

2008-06-16T21:56:00.001-07:00

Rosacea News May 2008

1. combining Azithromycin with Protopic (tacrolimus) topical

This paper details a somewhat exotic combination therapy: oral azithromycin and topical tacrolimus. It offers an alternative to the more common doxycycline + metrogel combination. The authors mention that this is not a first line therapy; "a combination of oral azithromycin and …

2 Flushing: it’s all in your nerves and emotions

In November 2006 I blogged about taking part in some research at Murdoch University investigating the relationship between stress and the flushing of rosacea. Recently the researcher, Daphne Su, has thanked the trial participants by circulating a summary document. The research has been written up as a thesis so this summary was a short description of some the …

3. Low Level Light Therapy details posted

TP has posted an update to her Low Level Light Therapy- an overview thread at the Rosacea Support Forum.

This recent update is from a document called Cellular Mechanisms of Low-Power Laser Therapy.

Thanks for the update TP. This thread is worth a read for those interested in Low Level Light Therapy (LLLT) such as LEDs, infrared, red and blue light.

4. Marketing company seeks interviews in Houston, TX

Schlesinger Associates are looking for rosacea patients on Friday June 13 2008, to attend an interview for an hour at their Galleria Area location in Houston TX. Their address is 1455 West Loop South, Suite 500. …

5. Google Health Launches, rosacea is included as a condition

Google has been talking for a while about their push into health services. One of their stated features of Google Health is "Learn about health issues and find helpful resources: Review trusted information on diseases and conditions and learn about possible medication interactions and other topics to talk your doctors about." As part of their new offering Google Health has created some Condition References. …

6. does using a computer screen worsen rosacea symptoms ?

Rosacea sufferers sometimes bring up the topic of computer screens and indeed lighting in general as a trigger for their rosacea. Sadly there seems to be little conclusive literature available on this topic. A 1985 study in Norway, Does visual display terminal work provoke rosacea? was able to show that rosacea and seborrheic dermatitis sufferers were over represented in …

7. cathelicidins regulated by Vitamin D3

Another paper stemming from the partly NRS funded research into the role of cathelicidins and its role in rosacea. A lot of publicity and publications have resulted from Dr. Gallo’s research. This avenue of research into rosacea looks promising so lets hope that more resources target involved with this area of research. Those that interested in the role that Vitamin D3 play …

8. metrogel also works for seborrheic dermatitis

This paper found that 0.75% metrogel worked just as well as ketoconazole 2% cream in treating SD. The study found that both were able to offer significant improvement with similar side effects. The authors suggest that because there is so little evidence of anti fungal activity of metronidazole, it is difficult to speculate …

9. Sebclair for seborrheic dermatitis

This recently published paper investigates the effectiveness of a `novel steroid-free cream containing multiple active ingredients’, called Sebclair to treat facial seborrheic dermatitis.

This product sounds quite interesting for rosacea and rosacea/SD sufferers. Little information about Sebclair is currently available on the internet.

10. SIBO eradication clears rosacea: are you serious ?

This sort of abstract just make me shake my head. If you read quickly you will think that this abstract suggests that Small Intestinal Bacterial Overgrowth (SIBO) causes rosacea. What this abstract is saying that is that rosacea sufferers seem to have a higher incidence of SIBO than non rosacea sufferers. The secondary result is that eliminating SIBO clears rosacea. Well that is no surprise …

11. Pycnogenol Redness Reducing Serum: any reviews ?

Pycnogenol® is the patented trade name for a water extract of the bark of the French maritime pine ( Pinus pinaster ssp. atlantica ), which is grown in coastal south-west France. Pycnogenol® contains oligomeric proanthocyanidins (OPCs) as well as several other bioflavonoids: catechin, epicatechin, phenolic fruit acids (such as ferulic acid and caffeic acid), and taxifolin. Procyanidins are oligometric catechins found at high concentrations in red wine, grapes, cocoa, cranberries, apples, and some supplements such as Pycnogenol®.

Rosacea News April 2008

2008-05-08T04:26:00.001-07:00

1. Clarisonic issues voluntary recall

If you have a Clarisonic Skin Care Brush manufactured prior to July 2007 you may like to read the Voluntary Recall from Clarisonic. Thanks for the note by Melissa in the forums. For product manufactured prior to July 2007 Clarisonic is voluntarily recalling Clarisonic handles and chargers in response to product safety concerns. The issue is limited to the product’s internal …

2. Oracea approved for much of Europe

In the news this week is an announcement that Oracea is on its way to being approved for sale in Germany, UK, Italy, Austria, Ireland, Sweden, Finland, Luxembourg and The Netherlands. European Regulatory Authority (EMEA) Recommends Granting Of Marketing Authorization For MediGene’s Drug Oracea MediGene AG announced that the European Medicines Agency (EMEA) Committee for Medicinal Products for Human Use (CHMP) has concluded …

3. Mysterious topical IDP-115 being trialled

A seemingly new topical treatment for rosacea is being trialled by Dow Pharmaceutical Sciences. The product is being evaluated firstly for the number of inflammatory lesions and global severity, and secondly for redness. This, along with the trial lasting 12 weeks, and the large size of the trial leads me to guess that IDP-115 is a metronidazole or azelaic acid variant.

4. Welcome to New York Times readers

If you are visiting rosacea-support.org today because of the article in SKIN DEEP - In a Perfect World, Rosacea Remains a Problem, WELCOME !

Rosacea is a common, progressive and often misunderstood disease. We hope that you find some useful resources on this site.

On this site you will find hundreds of news and research items. Use the Articles links on the left hand side to …

5. Kopec Naturals offering free Rosacea Relief samples

Laura Kopec from Kopec Naturals is offering free 1 oz samples of their Rosacea Relief product. According to their web site, Rosacea Relief contains, “Proprietary blend of Barbadensis vulgaris (aloe vera), Hamamelis virginiana (witch hazel), Melaleuca alternifolia (tea tree) oil, and other natural ingredients.” See her post at the Rosacea Support Forum - Free 1 oz Sample of Rosacea Relief for more information. …

6. RGS5 gene can reverse angiogenesis

From: Aussies stop cancer tumour frenzy Researchers based at the Western Australian Institute for Medical Research have discovered a gene that can reverse angiogenesis - the growth of blood vessels inside a tumour. Their work, led by associate Professor Ruth Ganss, is a world first and has been recognised by internationally-renowned scientific journal Nature in its weekly edition, published online today. …

7. NRS adds Q&A section to their web site

The NRS have announce a new section on their web site. Rosacea sufferers are now able to submit questions online and have them answered by a range of rosacea experts. From Ask the Doctors: Have a question about rosacea? Leading dermatologists, ophthalmologists, researchers and others will answer questions about this chronic but treatable condition. New questions are answered every month, so be …

8. acne rosacea sourcebook: a computer wrote it !!

Back in 2003 I ordered a copy of “The Official Patient’s Sourcebook on Acne Rosacea”. I was looking to read what was available on the topic of rosacea and this book was listed on amazon.com. The book confused me ; it was so bad. Little did I know, the book was written by a computer. The author, Philip M. Parker has some patents related …

9. aloe vera company seeks rosacea trial participants

Just posted to the Rosacea Support Forum is a request for rosacea sufferers who are interested in a new series of aloe vera capsules and gel. See Aloe vera company seeks participants for Rosacea study for more information. Aloemaxx Health Systems Inc, is a retailer of organic, non-toxic aloe vera products. Through the cooperation of rosacea-support.org, Aloemaxx is seeking twelve participants to take …

10. Rosacea-LTD User Reviews

Rosacea-LTD has been discussed on rosacea forums the internet for a long time. In fact one of the first message I posted in 1998 was looking for some feedback on this product. The fact that the company is still in business is a good sign.

This product consists of compressed disks of various salts and sulphur. You gently slide the product over wet …

11. warning: Singulair might cause depression

From the Wall Street Journal: Possible Suicide Link Prompts FDA to Probe Merck Asthma Drug: The Food and Drug Administration said it is investigating a possible association between the widely used asthma medication Singulair and behavioral changes, including suicide...

Rosacea News March 2008

2008-04-01T23:23:00.001-07:00

1. Pyratine-6 Now Available from physicians

The Anti-Aging product Pyratine-6 is now available to buy from some physicians. Pyratine-6 is a new product that is a derivative of Kinetin. Their new web site has launched at pyratine-6.com. You can find a stockist on their web site.

2. angiogenesis: lymphatic and mast cell involvement

The pathogenesis (how a disease progresses from mild to severe forms) of rosacea is a complicated and poorly understood process. Likewise the growth of new blood vessels, thought to be important in the development of rosacea, is also a complicated and mysterious process. The NRS has updated their blog with an Update on Angiogenesis.

3. Sansrosa Phase 3 Delayed until END of 2008

According to the just published earnings call, Collagenex have been asked to undertake a additional Phase 2 study before commencing Phase 3. These additional studies will take several months, delaying the start of Phase 3. Collagenex are still hopeful of commencing Phase 3 studies some time before the end of 2008. These additional studies are to confirm that the diseased rosacea skin does not allow …

4. Prosacea User Reviews

Prosacea is a topical gel, available over the counter at stores like Walgreens. Prosacea is only briefly mentioned in the online support groups. Below is a hopefully balanced selection of user comments from rosacea sufferers who have tried Prosacea.

5. moderate exercise may help your rosacea

Some rosacea sufferers report good results if they exercise moderately but regularly. It is well known that regular exercise is good for stress relief and of course your general well being. But what about improving your skin ? Is that possible ? This paper is suggesting that exercise can reduce the amount of cytokines generated as part of the inflammatory response that is believed to …

6. The Warm Room Flush: what you wished you always knew

You may have noticed that your face flushes when you enter a warm room, but have you ever thought about how that process actually works ? Well, a nicely written article just released on the web goes into detail about how your body responds when you go from a cold room to a warm room. Colin Dahl, rosacea sufferer himself, from Australian Sciences has created this article to help rosacea sufferers understand the thermoregulatory roots of facial flushing in a simple, easy to read manner. The following couple of paragraphs from Chapter 1 give an accurate description of the contents of the booklet.

Rosacea News February 2008

2008-03-10T19:01:00.001-07:00

1. News anchor gets burned by photo facial

From: Lucy Noland offers tip for others to avoid the same pain. 11 News anchor Lucy Noland wanted to share her personal experience so that others can avoid getting burned. A few weeks ago, I went in to get some freckles removed. The result? I was left burned so badly that I couldn’t work for a week. From the bright …
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2. Galderma buys CollaGenex for $420m

Collagenex is set to become a subsidiary of the much bigger Galderma, after CollaGenex agreed to a merger. So 2 of the biggest pharmaceutical companies involved with make rosacea treatments are to become the same company. Galderma has long been associated with rosacea treatment, and is best known for the metronidazole based topicals metrogel, metrocream and metrolotion. CollaGenex has become known in recent years …

3. finacea is good for acne and hyper pigmentation as well

This poster session is seeking to expand the appeal of Finacea (which contains Azelaic acid 15%) beyond rosacea. The result is that the authors are suggesting that finacea is also possibly good for acne vulgaris and hyperpigmentation as well as rosacea. If you are …

4. NRS updates their FAQ

The National Rosacea Society has updated their Frequently Asked Questions page, as reviewed and edited by Dr. Mark Dahl (who is on the Medical Advisory Board of the NRS). They have included 44 questions ranging from `What causes rosacea’ to `Do steroids induce rosacea’. Publications from the NRS are carefully written to be neutral and to be of good general interest. For those …

5. Collagenex CEO says rebound not yet seen in Sansrosa

February 21st, 2008, by Ben

Regarding another investor conference today, CEO Colin Stewart presented and most of the information was familiar. However, during the question period, an audience member asked about rebound flushing/redness during the Sansrosa / COL-118 trials. The following is what was said:

Man: “I realize that it’s an in-class, COL-118, it’s kind of difficult to work out the economics of the opportunity. Now, the fact …

6. Clarisonic user reviews

With the recent push by Clarisonic to promote their sonic brush as treatment for rosacea, I thought it might be interesting to see some reviews of users of the Clarisonic Skin Care System by rosacea sufferers. Although it is expensive, it does seem to be working quite well and so far no-one is reporting that it has irritated their …
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7. using a sonic brush to treat rosacea and seb derm

Here are 2 more recent Poster Sessions promoting the usage of the Clarisonic Skin Care System. Previous publications addressed treating seborrheic dermatitis with the Clarisonic brush. The manufacturers are now targeting their sonic brush as a treatment for rosacea itself. These papers are readying Clarisonic’s push into treating rosacea. It is an interesting idea to approach cleansing from …

8. LED helps recovery after IPL, reduces redness

This paper is good news for both those undergoing IPL treatments and those interested in Light Emitting Diode (LED) therapy as a anti-redness treatment. Patients treated immediately after IPL with a LED device showed that their post-treatment redness subsided faster compared to not also being treated with LED. Use of light-emitting diode photomodulation to reduce erythema and discomfort …

9. Malassezia Globosa causes seborrhea, Pyrithione Zinc is effective

Interesting threads on the Rosacea Support Forum started by Artist. Apparently it is well known but it was a surprise to me that seborrheic dermatitis is not caused by Pityrosporum ovale, but in fact Malassezia Globosa. The second bit of information that was surprising to me was not only that ketoconazole is effective against M. Globosa, but so is Pyrithione Zinc (PTZ). Some great links …

10. rosacure helps redness after 1 month

This paper looks to be suggesting that the silymarin/msm containing topical, rosacure/synchrorose was well tolerated and helps with the redness of rosacea. Silibinin (INN) (silybin, Legalon®) is the major active constituent of silymarin, the mixture of flavonolignans extracted from plant Milk thistle. Methylsulfonylmethane (MSM, or dimethylsulfone) is an organic sulfur compound belonging to a class of chemicals known as …

11. oral repeat prescriptions more popular than topicals

This paper comes up with the seemingly simple and innocuous result that rosacea sufferers are more likely to fill prescription repeats for oral treatments compared to topicals. This lead to the suggestion by Collagenex that sufferers are generally more satisfied with the effects of oral treatments. In recent press release they further suggested that this was a reason that the market for Oracea was large …

12. aveeno ultra calming with feverfew well tolerated

This paper was sponsored by Johnson & Johnson, who make the Aveeno Active Naturals Ultra Calming range. J&J are attempting to target rosacea sufferers with their aveeno range that contains feverfew. Rosacea sufferers are difficult to target with cosmetics so it is encouraging to see large companies doing background research to create suitable products. Poster Abstracts, American Academy of Dermatology 66th Annual Meeting, February …

13. oxymetazoline good for 6 hours and safe for 3 months

This poster abstract is an update to the paper that was published in Archives of Dermatology in 2007 and was covered by Rosacea News as Sansrosa’s sister to enter redness race. This now expanded abstract suggests that oxymetazoline is effective for up to 6 hours after application and no side effects have been seen after 3 months usage. …

The Warm Room Flush: what you wished you always knew

2008-03-02T05:55:00.001-08:00

A Practical Understanding of Rosacea, Part 1: Heat Regulation and the Warm Room Flush Phenomenon, By Colin Dahl, Chief Scientist, Australian Sciences.

The simplified biological mechanics of rosacea have been explained in the booklet. Minimal medical terms have been used and may be further referenced online. I believe that a basic understanding of how the body deals with heat regulation and dilation of blood vessels is needed if you want to begin reversing this and other forms of facial flushing associated with rosacea.

It is not the intention of this booklet to name or deal with specific chemicals. The reason for this is simple, once you have excessive blood vessels and nerves in your skin, you will have an excess of numerous inflammatory chemicals. It is the intention of this booklet to highlight the systems involved, so that these systems can be used in your favor.

Often we see terms like nerve-mediated vasodilation, cutaneous nerves, angiogenesis (and a new one axonogenesis), sympathetic nerves, neurotransmitters, neuropeptides, nerve growth factors etc. thrown around. Finally here is a document that puts them together in context. Whatsmore, it is a pleasure to read.

I like that the document doesn't suggest that IPL is the end-game for treating flushing. See the document for Mr. Dahl's thoughts on how to enhance the effectiveness of IPL therapy.

If you go to the Products section of the web site you will also see that Australian Sciences have products related to rosacea in the development pipeline. From the PDF;

Australian Sciences is developing a range of effective products aimed at assisting in the reduction of excessive skin cell activity due to environmental factors such as sun exposure. Australian Sciences has conducted extensive research into the normalization of inflammatory skin cells with natural compounds such as silymarin, egcg, vitamin B12 and many others. Independent research has also showed these compounds to be effective for other inflammatory skin disorders such as atopic dermatitis and psoriasis. We believe these products can help normalize skin cells and assist in the long-term reversal of excessive skin infrastructure.

Further benefits can be achieved through reducing the exposure of skin cells to environmental factors. A major contributor to excessive skin cell activity is sunlight. Not only is the ultraviolet radiation a major contributor, but the excessive heat energy delivered to skin cells is enough on its own to cause problems for those with rosacea.

Stay tuned for further information.

Read the document here: Australian Sciences Rosacea Page.

What do you think about this document ? Leave a comment below or discuss it online at the Blushing and Flushing Forum at the Rosacea Support Forum.

Rosacea News January 2008

2008-02-05T00:47:00.001-08:00

Rosacea News January 2008

1. most popular blog posts in 2007

January 2nd, 2008, by Digital Davo, in the news

Looking through my web site statistics I can see that the following Rosacea News items received the most visits during the year. I’m looking forward to 2008 to see what makes the Rosacea News. 1. eucerin redness relief product reviews In 2005 a new range of skin care products from Eucerin (Beiersdorf Inc) called Eucerin Redness Relief was released. ...

2. not on your face, it is possible

January 8th, 2008, by Digital Davo, accutane, macrolides, papules & pustules, steroids

One often asked question by newly diagnosed sufferers is `can you get rosacea on areas other than your face’. The usual answer is no; you normally only see rosacea symptoms on the flushing zone areas in the central areas of your face. This paper slightly dispels this idea with a case report about one patient who had rosacea lesions on his arm, and upper chest …

3. AAD Poster Sessions: oxymetazoline

January 16th, 2008, by Digital Davo, in the news, research

The 66th Annual Meeting of the American Academy of Dermatology is due to take place in San Antonio, TX, from Feb 1-5. Of most interest to rosacea sufferers is the poster sessions where recently published research and related products are promoted to dermatologists. Based on the proposed poster sessions, the following look interesting. P400: Successful treatment of the erythema and flushing of rosacea using a …

4. NRS announces 2008 research grants

January 17th, 2008, by Digital Davo, research foundation

The NRS has announced four new grants for ongoing research into the knowledge, cause and treatment of rosacea. Dr. Gallo, Dr. Granstein and Dr. Steinhoff have been awarded grants to continue their existing NRS-funded research while Dr. Helfrich has been awarded a grant for new areas of funding. Briefly, (for full details, see the NRS Blog): Dr. Richard Gallo, …

5. 100mg doxycycline no better than oracea

January 18th, 2008, by Digital Davo, doxycycline, oracea

Collagenex is reporting today that Oracea is equally effective as 100mg of doxycycline. This latest press release is a culmination of a trial that we have reported previously - oracea plus metrogel, better than 100mg doxycycline plus metrogel ? and also a 2007 SkinMed paper; maximum effective dose of doxycycline is 40mg a day. The main point of the trial was …

6. Clinique Redness Solutions: user reviews

January 22nd, 2008, by Digital Davo, cleansers, moisturizers, topicals

A new range of products for problem red skin called Clinique Redness Solutions has recently been launched.

The range consists of ; Redness Solutions Urgent Relief Cream is said “rushes soothing relief to upset skin. Quickly calms flare-ups of visible redness, irritation.” Redness Solutions Daily Protective Base SPF 15 is claimed “Protects …

7. Clinique Redness Solutions Ingredients

January 24th, 2008, by Digital Davo, steroids, topicals

A recent Rosacea News post listing the some preliminary user reviews for Clinique Redness Solutions was unclear on whether the Urgent Relief Cream contains cortisone. Well the answer is yes, it does. This would suggest that this product is not suitable for long term use for rosacea sufferers. It is not a surprise that a product that claims up soothe upset skin would …

8. otophyma: rosacea swelling and growth of the ears

January 27th, 2008, by Digital Davo, rhinophyma

Hot on the tails of the recent paper about getting rosacea on areas other than your face comes this paper about rosacea related swelling and growth of the ear. This case report covers a patient who had an enlarged ear which was found to be caused by the same sort of rosacea growth seen in rhinophyma - called lymphedema. An additional suggestion is that …

9. granulomatous variant not a rosacea subtype

January 29th, 2008, by Digital Davo, research

This just published paper is confirm that belief that the granulomatous forms of rosacea are not genuine subtypes in the same ways as the 4 well-know subtypes: ER, PP, PHY and OC (my abbreviations). A one-line summary of this paper is that a group of patients who had tests to show that they had granulomatous rosacea did not have any …

Rosacea News December 2007

2008-01-01T19:17:00.001-08:00

1. Senetek Trialling Pyratine 6 / PRK124

December 30th, 2007, by Digital Davo | clinical trials, papules & pustules

A new trial has just been posted that will be looking at how Pyratine 6 (a variant of Kinetin) treats the papules & pustules, redness and visible blood vessels of rosacea. From Clinical Trial NCT00580723: Effects of PRK 124 Lotion in Acne Rosacea The purpose of this open-label study is to determine the tolerance and efficacy of twice-daily application …

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2. Nerve Growth Factor inhibitor - acerola seed extract

December 27th, 2007, by Digital Davo | patents, seborrheic dermatitis

Trawling patent applications is challenging but also interesting. There is a huge mine of information available for us to scavenge information that might lead to future treatments. I thought this patent was interesting because it deals with something that I hadn’t heard of before, but seems like it might have some potential. This patent application makes me wonder if we will see anything else …

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3. acne lotion good for cleaning pen from toys

December 21st, 2007, by Digital Davo | acne treatments, in the news

OK a semi-serious post for this time of year. An interesting blog posting over at Baby Toolkit suggests that 10% benzyl peroxide cream and sunlight is perfect for removing pen marks from a plastic doll. From Clear Unsightly Blemishes: the Case of the Ballpoint Baby Doll Here is before ; and here is after …

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4. Patents abound for treating rosacea with alpha agonists

December 19th, 2007, by Ben | patents

Their has been much talk lately about using alpha adrenoceptor agonists as rosacea treatments because they show vasoconstrictor actions. Some examples are brimonidine, oxymetazoline, naphazoline, and others.

There are quite a few patents out there discussing these, and even testing some of them. Some of these patents have been mentioned before on the site.

Here are links to some of these patents.

US20040242588
Compounds, …

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5. kinetin & niacinamide for anti-aging

December 14th, 2007, by Digital Davo | moisturizers, topicals

This study shows that kinetin and niacinamide work together well to provide anti-aging effects for asian skin. Previous studies that have been highlighted by Rosacea News have also shown that topical kinetin is a good anti-aging moisturizer for rosacea sufferers and may even show some benefit for rosacea symptoms. The clinical anti-aging effects of topical kinetin …

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6. get ready for ocular oracea

December 12th, 2007, by Digital Davo | doxycycline, ocular rosacea, oracea

Thanks for the tip from Ben. A clinical trial listed for treating both facial and ocular rosacea with Oracea suggests that Oracea might soon be marketed directly as an ocular rosacea treatment. This phase 2 trial’s purpose is to determine the safety and efficacy of sub-antimicrobial dose doxycycline in the treatment of patients who have both blepharitis and facial rosacea. The trial …

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7. FDA approves Lyrica for Fibromyalgia

December 10th, 2007, by Digital Davo | in the news

Whilst this was announced back in June this year, I thought it was worthwhile highlighting it here in case it is of interest to rosacea sufferers who also suffer from chronic pain. From the FDA Consumer Update: Living with Fibromyalgia, First Drug Approved People with fibromyalgia have typically turned to pain medicines, antidepressants, muscle relaxants, and sleep medicines. On …

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8. how Collagenex are Promoting Oracea

December 6th, 2007, by Digital Davo | oracea, tetracyclines

A recent investor presentation from Collagenex shows some interesting insights into how Collagenex are promoting Oracea. Oracea is promoted as safe and effective for long term use. It was reported that the average duration of Oracea therapy is 4 months, compared to an average of 2.5 months for other rosacea prescriptions. 52% of Oracea prescriptions are refills - the presentation suggests that …

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9. treating ocular rosacea with amniotic membrane transplant

December 4th, 2007, by Digital Davo | ocular rosacea

This case report of one patient shows a remarkable treatment possibility for severe ocular rosacea. The patient also suffered from papulopustular rosacea and rhinophyma and did not respond to full dose doxycycline. Three attempts to glue his perforated cornea failed. The paper suggests that corneal perforation is quite rare in ocular rosacea.

The amniotic membrane transplant was a success, both sealing the perforation, and restoring good …

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10. genetic links for psoriasis, lupus

December 3rd, 2007, by Digital Davo | research

A quick news bite about some new links found for a genetic root for psoriasis and lupus. I like that the reporter doesn’t try to dress up this announcement as anything other than a small advance in our knowledge of these 2 diseases. The research into a provable genetic link for rosacea symptoms is still at a very early stage. Maybe one day …

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most popular blog posts in 2007

2008-01-01T19:06:00.001-08:00

Looking through my web site statistics I can see that the following Rosacea News items received the most visits during the year.

I'm looking forward to 2008 to see what makes the Rosacea News.

1. eucerin redness relief product reviews

In 2005 a new range of skin care products from Eucerin (Beiersdorf Inc) called Eucerin Redness Relief was released. They are claimed as “Safe for sensitive skin and appropriate for Rosacea”.

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2. how to cure a red face

Many rosacea sufferers are looking for help to reduce the redness of their face. This is one of the first rosacea symptoms that people might notice. What treatments have fellow rosacea sufferers used to hide the ruddiness and angry face that sometimes accompanies rosacea ? I’ll go through what I see as your current best options.

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3. choosing a moisturizer

An excellent consumer report about how to choose a moisturizer. The article gives some background on how moisturizers are formulated, how they work, and the operation of common active ingredients. A table at the end of this document compares about 75 available moisturizers, classifying them under Face, Hands and Feet. Highly valuable for anyone searching for a moisturizer as part of their daily routine.

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4. treating rosacea with herbs

There is a lot of interest from rosacea sufferers in treating their rosacea with natural or herbal therapies and remedies. Many are keen to avoid treatments like antibiotics and metrogel. This paper is by far the best collection of information about natural products I’ve found.

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5. red face: when flushing isn't rosacea

This paper explores the different problems that may be causing flushing. The list of possible reasons other than rosacea is extensive. The author was kind enough provide a full copy of this paper, so contact me if you’d like to read it.

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6. focus on finacea

Finacea is a topical rosacea treatment made by Intendis. Its main active ingredient is azelaic acid 15%. Officially, finacea “is a topical treatment for the inflammatory bumps and lesions of mild to moderate rosacea”.

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7. periostat goes generic, get ready for oracea:

Periostat (20 mgs doxycycline hyclate) has been helpful to some rosacea sufferers. Originally developed to combat periodontal disease (gum disease), periostat was approved by the FDA in 1998. Recently the FDA approved the introduction of generic periostat equivalents.

Oracea contains doxycycline, the same active ingredient as CollaGenex’s gum disease treatment Periostat. CollaGenex is shifting its focus to the dermatology market following the approval of generic competition for Periostat.

(click to continue reading →)

8. ocular demodex - tea tree oil as a treatment:

(click to continue reading →)

9. focus on metronidazole

Metronidazole is a prescription drug that is available in several formulations. As an oral treatment it is known as flagyl. Topical metronidazole is available as noritate, metrogel, rozex, metrogel 1%, metrolotion and metrocream.

(click to continue reading →)

10. focus on low dose accutane:

The mechanism by which low dose accutane (isotretinoin) i.e. around 10mg a day, is effective in treating rosacea is not clearly understood. Just the name accutane is enough to strike fear into many doctors and patients.

Hopefully the following articles will provide some pointers to useful information when researching whether accutane/roaccutane is a suitable treatment for your rosacea.

(click to continue reading →)

Rosacea News November 2007

2007-12-06T22:19:00.001-08:00

1. COL-118/Sansrosa $150+ a month ?

A recent investor presentation from Collagenex gives some hints as to how Collagenex will price COL-118. Collagenex believe that their anti erythema product used for 2-4 months of treatment at $150 a month leads to a $330-660 million market. $150 a month for COL-118 treatment sounds like a lot. One wonders how much the suggested $150 a month will translate to at the pharmacy counter.

(click to continue reading →)

2. Sansrosa’s sister to enter redness race

PubMed pushed out an interesting abstract in the last couple of days. A bit of digging reveals what looks to be a running mate for COL-118/Sansrosa. COL-118 and Oxymetazoline appear to be promoted by separate groups of researchers. This is good news for rosacea sufferers as it means there may well be a choice between 2 topicals that can help address the redness and flushing of rosacea.

(click to continue reading →)

3. aspirin for flushing says Dr. Bikowski

Alluding to a link between rosacea and migraines, Dr. Joseph Bikowski says that aspirin should be the first line of defense against rosacea flushing. A recent article in Dermatology Times highlights the potential benefits (and risks) of taking low doses of aspirin long term for rosacea swelling and flushing.

(click to continue reading →)

4. Clinuvel trialling CUV1647 (melanotan) for skin cancer for transplantees

Getting some press in Australia currently is a story about a trial starting today in Melbourne. The trial will assess the efficacy of CUV1647 (also known as melanotan) to protect against skin cancer in patients who have had organ transplants. Patients who have received organ transplants are at a much higher risk of contracting skin cancer because of the immune suppressive drugs that they must take.

(click to continue reading →)

Rosacea News October 2007

2007-11-06T23:50:00.001-08:00

Rosacea News October 2007

1. the best moisturisers with sunscreen

I love CHOICE Magazine in Australia. They do great reviews, always concentrating on practical outcomes. A recent report dealt with moisturisers (yes we spell them with an "s") on the Australian market that also contain sunscreen. For those that want both the protection offered by a sunscreen and a good moisturizer, this report is for you.

2. ivermectin clears untreatable rosacea

In this case report of one patient, the papules and pustules of rosacea were difficult to treat until oral ivermectin was included in the treatment regime. This 2007 paper is similar to a 2002 paper, Treatment of rosacea-like demodicidosis with oral ivermectin and topical permethrin cream. The 2002 paper is also a case report of a single patient with recalcitrant symptoms

3. spotlight on rosacure (synchrorose) silymarin + MSM, user reviews

Rosacure has been around for a while and is easily available, but it seems that only a few rosacea-support members rave about it. The products genesis and marketing are good, so lets look at some of the available background information and product reviews.

4. measuring ocular rosacea severity

The National Rosacea Society has today posted a blog item about some new research into wanting to quantify the severity of ocular rosacea symptoms. From Scoring Aids Eye Research The new questionnaire, called the Severity Criteria of Ocular Rosacea (SCOR), includes more than 25 signs and symptoms of ocular rosacea observed by both physician and patient, including eye dryness, tearing and burning; history ...

5. tinted moisturizers, ever tried them ?

A great thread has been started at the Rosacea Support Forum on tinted moisturizers. The poster mimicocolulu has been writing some great posts lately. Here, in the new Makeup and Cover Up forum, she gives us the low down on how tinted moisturizers can work well for rosacea sufferers.

Rosacea News September 2007

2007-10-03T18:33:00.001-07:00

1. how metrogel works II - free oxygen radicals

Another recently published paper that seeks to understand the role of Reactive Oxygen Species in the development of rosacea. The inflammatory pathway that leads to rosacea symptoms is slowing gaining more and more attention. All rosacea sufferers should do themselves a favor and do some reading on the role of inflammation in rosacea.

http://rosacea-support.org/how-metrogel-works-ii-free-oxygen-radicals.html

2. Melanocorp gets warning from FDA for melanotan II

Looks like the FDA has finally caught up with Melanocorp for selling Melanotan II over the internet. Their web site currently down. "FDA Issues Warning Letter to Melanocorp, Inc. For Illegal Sale of Melanotan II Melanocorp, Inc. advertises the product Melanotan II on its Web site as an injectable tanning product, with additional claims that it is effective in protecting against skin cancer and rosacea."

http://rosacea-support.org/melanocorp-gets-warning-from-fda-for-melanotan-ii.html

3. an interview with Ann-Marie Lindstrom, The Rosacea Handbook

Here is the first in what I hope will be a series of interviews with a few rosacea writers that are mostly unknown to the online rosacea community.

Thanks to Ann-Marie Lindstrom for agreeing to answer some questions from Rosacea News.

http://rosacea-support.org/an-interview-with-ann-marie-lindstrom-the-rosacea-handbook.html

4. maximum effective dose of doxycycline is 40mg a day

There has been a lot of copy written about so-called low dose or anti-inflammatory dose doxycycline. This form of antibiotic therapy is one of the more promising recent therapeutic developments ; it will likely become a widely known and available treatment.

http://rosacea-support.org/maximum-effective-dose-of-doxycycline-is-40mg-a-day.html

5. Rosa Relief Face Cream offering free samples

Gary Hammerstrom from Bio-Application Technologies is offering a free sample of a new product his company has developed. His offer has been posted to the RSG as Free sample offer of a new product named Rosa Relief Face Cream.

http://rosacea-support.org/rosa-relief-face-cream-offering-free-samples.html

6. Long Pulse Dye Laser and Nd:YAG (Cynergy Multiplex) used together

This just published paper is a case report of one 60 year-old patient who was unresponsive to the usual first line rosacea treatments. Additionally 2 treatments with Lumens One IPL were unable to offer clearance.

http://rosacea-support.org/long-pulse-dye-laser-and-ndyag-cynergy-multiplex-used-together.html

7. new rosacea support forum: how to post

The new Rosacea Support Forum is up and running. This forum is one the companion forum to the email based Rosacea Support Yahoo!Group.

The new forum is fast, friendly and fun !

http://rosacea-support.org/new-rosacea-support-forum-how-to-post.html

8. an interview with Arlen Brownstein, Rosacea, Your Self-Help Guide

Thanks to Arlen Brownstein for answering some questions from Rosacea News.

http://rosacea-support.org/an-interview-with-arlen-brownstein-rosacea-your-self-help-guide.html

9. arnica montana for swelling and bruising

In a recent Rosacea News article the highlighted LPDL treatment regime used Arnica pre- and post- treatment to reduce the bruising and swelling associated with pulse dye laser.

http://rosacea-support.org/arnica-montana-for-swelling-and-bruising.html

10. an interview with Georgie Holbrook, Joy-Full Holistic Remedies

Thanks to Georgie Holbrook for answering some questions for Rosacea News

http://rosacea-support.org/an-interview-with-georgie-holbrook-joy-full-holistic-remedies.html

11. topical kinetin (kinerase) moisturizer for anti-aging

This article was first highlighted by Rosacea News in March 2006 as result of the 2006 Annual Meeting of the AAD, Poster Session in San Francisco. The paper was called Tolerability and efficacy of a moisturizing lotion containing 0.1% kinetin for improving the signs of acne rosacea in facial and neck skin

http://rosacea-support.org/topical-kinetin-kinerase-moisturizer-for-anti-aging.html

12. incyclinide fails for rosacea, acne still possible

Despite promising looking Phase 1 and initial Phase 2 dose finding studies, Incyclinide will no longer be developed as a treatment for rosacea.

http://rosacea-support.org/incyclinide-fails-for-rosacea-acne-still-possible.html

Rosacea News August 2007

2007-09-03T22:39:00.001-07:00

Rosacea News August 2007 - http://rosacea-support.org/2007/08

1. Cathelicidins make the news

Lots of buzz at the moment about the publicity raised by a nature.com article about Cathelicidins.

This article is a result of a few years of research by Dr. Gallo. We’ve been reading about this research, some of it sponsored by the NRS, since at least the Fall of 2002

2. sanrosa (COL-118) phase 2 looking promising

As was mentioned in January this year, COL-118 (product code used for the sansrosa product) is expected to move from Phase 1 to Phase 2 in 2007. Collagenex has published results from their Phase 2 trials that were conducted in order to test some dosage levels to assess how they effective they are and also any side effects.

3. Rosacea News is changing

As I approach 300 articles for Rosacea News, it is time for a bit of a change. I started writing items in July 2005, and back then I wasn’t really sure what I’d find. Since then I’ve learnt heaps as I trolled the internet looking for fresh and interesting developments in the world of rosacea. Surprisingly, there is a lot of good information out there.

Dan has done a great job in creating and maintaining the Rosacea Supplements & Resources Pages. I’ve just checked the server stats and here are links to the most popular pages.

5. how to cure a red face (facial erythema or redness)

6. RR: Summer 2007 Roundup, demodex bacteria

The NRS have published their Summer 2007 edition of Rosacea Review. They highlight a paper presented at this year’s AAD Meeting in Washington DC.

Rosacea News July 2007

2007-08-30T01:33:00.001-07:00

Rosacea News July 2007

view all the July News Items online: http://rosacea-support.org/2007/07

1. oracea plus metrogel, better than 100mg doxycycline plus metrogel ?

A clinical trial, sponsored by CollaGenex, is recruiting patients to see how Oracea compares to doxycycline (100mg once a day) when combined with metrogel 1%.

We can see from a Collagenex annual report that COL-101 was the name for Periostat MR, which then became Oracea.

oracea plus metrogel, better than 100mg doxycycline plus metrogel ?

2. organic tomatoes higher in quercetin and kaempferol

In a 10 year study highlighted by the BBC, organic tomatoes were found to contain twice the levels of flavonoids compared with commonly grown tomatoes.

organic tomatoes higher in quercetin and kaempferol

3. Melanotan causing vision problems ?

An interesting thread over at the Rosacea Forum to do with the safety of taking melanotan. Steve, who is using Melanotan himself, points to a thread on a Melanotan message board where Robert is reporting some issues with gradual onset vision problems ;

Melanotan causing vision problems ?

4. VEGF and macular degeneration any link to rosacea ?

It is not only rosacea that is interested in how VEGF affects blood vessels and thus how a disease that is related to blood vessels progresses. The `wet` type of macular degeneration is associated with the growth of abnormal blood vessels. Thus there may well be some common areas of research between rosacea and macular degeneration

VEGF and macular degeneration any link to rosacea ?

5. Daily Telegraph: seeing red, how to combat rosacea

It is nice to see that slowly newspaper articles on rosacea are becoming more informed. One might even think that they are surfing the net to see what new information is out there.

Daily Telegraph: seeing red, how to combat rosacea
_________________

Rosacea Support and News Pages on the move

2007-07-12T00:51:00.001-07:00

The Rosacea Support Group and Rosacea News pages are moving to a new site. Yes that's right, after quite a few years at rosacea.ii.net they are on the move to a new wordpress inspired site at rosacea-support.org ;

Now with the ability to leave a comment on every page and a great search feature and posts all nicely categorised.

Coming soon a new forum as well.

If you are an internet wizard and use a feed reader, you can just click here ;

Enjoy !

Rosacea News June 2007

2007-07-06T17:25:00.001-07:00

1. Trial recruiting for Pulse Dye Laser with Photodynamic Therapy

TRIAL: The Bispebjerg Hospital in Copenhagen is currently recruiting patients for a study comparing the "efficacy and adverse effect from long-pulsed dye laser versus long-pulsed dye laser-mediated photodynamic therapy for acne vulgaris and rosacea." The study is titled Laser-Mediated Photodynamic Therapy of Acne Vulgaris and Rosacea

http://rosacea.ii.net/news/2007/06/trial-recruiting-for-pulse-dye-laser.html

2. cetaphil moisturizing cream helps rosacea dry skin

PAPER: This study is saying that a gentle moisturizer is an important part of a rosacea beating regime. This was one of the gems that took me years to realize. In order to best treat rosacea, you will need to find a good gentle skin care routine. This routine should include a cleanser, moisturizer and sunscreen. Any prescription or over the counter topicals can then be added to your gentle care regime.

Beneficial use of Cetaphil(R) Moisturizing Cream as part of a daily skin care regimen for individuals with rosacea. J Dermatolog Treat. 2007;18(3):158-62., Laquieze S, Czernielewski J, Baltas E. , PERITESCO. Paris. France.

http://rosacea.ii.net/news/2007/06/cetaphil-moisturizing-cream-helps.html

3. anxiety, depression and being obsessed with your skin

NEWSPAPER: From: This is London, from the Evening Standard: Train suicide of woman depressed by her wrinkles

What a terribly sad story. Rosacea can be an all consuming disease and there is definitely a danger in becoming obsessed with your skin. The struggle to look normal can be too much for some, sadly. Please everyone realize that other people really aren't as interested or worried about your skin as you are. If you feel you aren't coping with your anxiety or feelings about yourself then please be brave enough to see a doctor and ask for some help.

http://rosacea.ii.net/news/2007/06/anxiety-depression-and-being-obsessed.html

4. WP: Fashion & Beauty Article: Seeing Red

NEWSPAPER: It is not very often than an online newspaper or news site features a half decent article about rosacea. This article from the Fashion & Beauty section of the Washington Post is reasonable for a mass audience paper. Rosacea is still a mystery to the population at large, so it is encouraging to see this sort of article.

http://rosacea.ii.net/news/2007/06/wp-fashion-beauty-article-seeing-red.html

5. metrogel: how it gets into your skin

PAPER: Two recently published papers look at the processes involved when you apply metrogel topically. The first abstract just tells us that they undertook some new ways of measuring metronidazole absorption, but doesn't reveal their results.

The second abstract suggests that a cream based metronidazole formulation (presumably metrocream, but could also include Noritate) had the greatest absorption when tested with human skin. They suggest that future research is needed to determine if indeed this makes any difference to rosacea symptoms.

http://rosacea.ii.net/news/2007/06/metrogel-how-it-gets-into-your-skin.html

6. demodex mite bacteria causes the inflammation ?

PAPER: This paper is proposing that a particular type of bacteria taken from a demodex mite, called Bacillus oleronius is capable of producing an inflammatory response. As the mite was isolated from a patient with papulopustular rosacea the tempting conclusion is that this bacteria has caused these rosacea symptoms. This part is of course not confirmed, just the fact that it is possible to isolate a bacteria that causes an inflammatory response in humans.

http://rosacea.ii.net/news/2007/06/demodex-mite-bacteria-causes.html

Rosacea News May 2007

2007-06-04T19:45:00.001-07:00

1. RRF funded study: cathelicidins and VEGF reduced by IPL/PDL

The NRS has published on their blog some results from a recently
concluded study. The study was titled `Structural and biologic changes in the rosacea skin induced by pulse dye laser and intense pulsed light', and was part funded by the now defunct Rosacea Research Foundation.

http://rosacea.ii.net/news/2007/05/rrf-funded-study-cathelicidins-and-vegf.html

2. wearing contact lenses and ocular rosacea

Many rosacea sufferers, especially those who suffer from ocular rosacea wonder if they will ever be able to regularly and comfortably wear contact lenses. When your eyes are sore, gritty and blurry would one want to consider trying to apply a contact lens ? I don't have any
ocular symptoms but I do know that I take it as right to be able to
wear contacts instead of the hassle of glasses.

PAPER: In this article, Contact Lens Wear in The Rosacea Patient (which was mentioned in a recent edition of Rosacea Review), Dr. Mannis lists the factors involved with the successful wearing of contact lenses when you suffer from ocular symptoms.

http://rosacea.ii.net/news/2007/05/wearing-contact-lenses-and-ocular.html

3. melanotan: could it cause skin cancer ?

This article from the DailyMail is offering some warnings about being
too quick to jump on the Melanotan II bandwagon. It is worth
remembering on top of all of the warnings below, that Melanotan
specifically as a rosacea treatment is also something we know very
little about. I think that the combination of rosacea sufferers
desperate for relief, the relative ease of obtaining Melanotan, and the fact that so little is known about its effects, is a recipe for
dangerous outcomes.

NEWS PAPER: Pretty pills: The dark side of the latest underground
beauty trend

http://rosacea.ii.net/news/2007/05/melanotan-could-it-cause-skin-cancer.html

4. elidel vs. protopic, does it work for rosacea bumps ?

This recently published blind study suggests that elidel (pimecrolimus)
is no better for rosacea papules and pustules than the vehicle it uses.

A previous study in 2005, Pimecrolimus for treatment of acne rosacea
suggested that elidel could indeed be useful for rosacea, but this
study was not a double blind study - it was not compared to another
inactive topical.

PAPER: Pimecrolimus cream 1% for papulopustular rosacea: a randomized vehicle-controlled double-blind trial.

http://rosacea.ii.net/news/2007/05/elidel-vs-protopic-does-it-work-for.html

5. incyclinide dosage trials: 40mg too much

Collagenex has announced that their ongoing trials to find the best
dosage for Incyclinide have discovered that 40mg can cause
photo-toxicity.

PRESS RELEASE: CollaGenex Pharmaceuticals Discontinues 40 mg Cohort of Phase II Dose-Finding Study of Incyclinide for the Treatment of Acne

http://rosacea.ii.net/news/2007/05/incyclinide-dosage-trials-40mg-too-much.html

Rosacea News April 2007

2007-05-02T05:27:00.001-07:00

1. Chlamydia pneumoniae (Cpn) and azithromycin
PAPER: The role of Chlamydia pneumoniae in the etiology of acne rosacea: response to the use of oral azithromycin.

As a followup to the recent note pathogen infection (Chlamydia pneumoniae) cause theory, comes a recently published paper, the first to address Cpn and Rosacea. This paper is very preliminary, but at least now Cpn is on the map.

http://rosacea.ii.net/news/2007/04/chlamydia-pneumoniae-cpn-and.html

2. Pyratine 6 (vs. Kinetin) reduces redness and acne lesions

WEB Site: The internet Press Release sites are full of an announcemet from Senetek about a product called Pyratine 6 and its possible use in treating rosacea. The announcement is based on a comparison of Pyratine 6 with another of Senetek's products - Kinetin.

http://rosacea.ii.net/news/2007/04/pyratine-6-vs-kinetin-reduces-redness.html

3. IPL excellent for treating red face and broken blood vessels

This 2007 paper confirms another study which was published in the same journal in 2003.

PAPER: Objective Evaluation of the Effect of Intense Pulsed Light on Rosacea and Solar Lentigines by Spectrophotometric Analysis of Skin Color.

http://rosacea.ii.net/news/2007/04/ipl-excellent-for-treating-red-face-and.html

4. anti-flammatory actions of tetracyclines

This article, just published is adding to body of research of the anti-inflammatory actions of the tetracycline family.

PAPER: Anti-Inflammatory Activity of Tetracyclines

http://rosacea.ii.net/news/2007/04/anti-flammatory-actions-of.html

5. oxytetracycline (Terramycin) joins low dose antibiotics

This paper (sadly only available in Polish) highlights the fact that one more tetracycline - oxytetracycline is joining the ranks of proven low dose antibiotics. A normal dose of oxytetracycline is 250-500mg four times a day.

PAPER: Oxytetracycline--mechanism of action and application in skin diseases

http://rosacea.ii.net/news/2007/04/oxytetracycline-terramycin-joins-low.html

6. cutanix goes offline, gets letter from FDA

A few people have noticed that Cutanix seems to have vanished off the face of the internet. Their web sites at cutanix.com, tvdepot.com are offline, and their corporate web site at bioformmedical.com no longer even mentions Cutanix.

http://rosacea.ii.net/news/2007/04/cutanix-goes-offline-gets-letter-from.html

7. flavay anthogenol hydrates and reduces skin stress

I thought this product sounded interesting, especially as it is professionally promoted, readily available, but little is known about how well it works for rosacea stressed skin. Anything that has been proven to reduce oxidative stress and help hydration could also help in rosacea.

http://rosacea.ii.net/news/2007/04/flavay-anthogenol-hydrates-and-reduces.html

flavay anthogenol hydrates and reduces skin stress

2007-04-30T02:02:00.001-07:00

"In addition to being a potent antioxidant, ANTHOGENOL is best known for the nutritional support it gives to the vascular system, especially to the thin and delicate capillaries where all the system’s essential functions culminate."

[Proven Health Benefits for Circulatory System]

also sound interesting.

Only time and user feedback will tell how well this supplement works. If you do try Anthogenol please post over at rosacea-support and let us know how you get on.

Anthogenol is made from pine bark and grape seed extract ;

Dr. Masquelier received several patents for the commercial extraction and isolation of OPCs from pine bark and grape seeds. It is these highly defined complexes that have been subject to intensive biological, toxicological, pharmacological and analytical research; and approved in Europe as over-the-counter medicines.
[Masquelier on OPCs and grape seed extracts and pine bark extracts]

The web sites are professional looking so the company is investing in the promotion of this product.

One relevant looking study is below ;

Anti-Inflammatory and Skin-Hydrating Properties of a Dietary Supplement and Topical Formulations Containing Oligomeric Proanthocyanidins, B. Hughes-Formella, O. Wunderlich, R. Williams, Bioskin GmbH, Hamburg, Germany. Skin Pharmacology and Physiology 2007;20:43-49
Background: Anti-inflammatory and skin hydration properties of a dietary supplement and 2 topical formulations (Anthogenol) with oligomeric proanthocyanidins were investigated.

Methods: Forty-two subjects were randomized into 2 groups: one taking the dietary supplement (100 mg/day) and the other without supplement. After 4 weeks, erythema was induced using UV radiation followed by treatment with topical cream or lotion. Erythema was measured for up to 72 h after irradiation. Skin hydration after 1 and 2 weeks of application of the cream and lotion was also measured in separate test fields.

Results: Both topical formulations led to a significant suppression of erythema formation and the dietary supplement led to an additional slightly stronger suppression. Thus 72 h after UV exposure and compared to the control fields of patients that had not taken a dietary supplement, erythema was slightly (13.2%) lower in the subjects that had taken a dietary supplement. The cream resulted in a maximal reduction of erythema of 45.9% (p = 0.0015), while the lotion resulted in a maximal reduction of 53.1% (p = 0.0002). Both topical formulations also increased skin hydration (by nearly 20%; p < 0.002 for all combinations of dietary supplementation and topical treatment) and the hydration was higher in the group taking the dietary supplement.

Conclusion: The regular use of Anthogenol products may help to protect from free-radical-mediated skin inflammation and to increase skin hydration.

Further Reading ;

ocular demodex, tea tree oil as a treatment

2007-04-09T23:30:00.001-07:00

ocular demodex, tea tree oil as a treatment

This recently published paper suggests that a variety of ocular symptoms might be caused by demodex infestation. Six patients all having demodex present, and suffering with recalcitrant symptoms (including 4 diagnosed with rosacea) were given tea tree oil for a weekly eyelid scrub and tea tree shampoo for a daily scrub. All patients showed a large decrease in demodex counts and relief from their symptoms. Other recently published studies are showing that tea tree oil kills demodex.

Eucerin Redness Relief: product reviews

2007-04-09T23:29:00.001-07:00

Eucerin Redness Relief: product reviews In 2005 a new range of skin care products from Eucerin (Beiersdorf Inc) called Eucerin Redness Relief was released. They are claimed as "Safe for sensitive skin and appropriate for Rosacea".

aveeno ultra calming with feverfew: product reviews

2007-04-09T23:28:00.001-07:00

aveeno ultra calming with feverfew: product reviews There is a lot of interest from rosacea sufferers in treating their rosacea with natural or herbal therapies and remedies. Many shy away from treatments like antibiotics and metrogel. So far the best collection of information about natural products I've found is a paper called Treatment of Rosacea with Herbal Ingredients. One of the herbs mentioned in that paper was Feverfew.

Rosacea News March 2007

2007-04-01T20:23:00.001-07:00

Rosacea News March 2007

1. Xolegel for treating seborrheic dermatitis (seb derm)

PAPER: Anti-inflammatory effects of ketoconazole: Clinical benefits in
the treatment of seborrheic dermatitis

http://rosacea.ii.net/news/2007/03/xolegel-for-treating-seborrheic.html

2. wanted: 11-18 year olds for survey about online support

SURVEY: Fiona Fox, who is a PhD student at The Centre for Appearance
Research, University of the West of England, Bristol, UK, is looking
for young people with a skin condition to take part in some research
online.

http://rosacea.ii.net/news/2007/03/wanted-11-18-year-olds-for-survey-about.html

3. ocular rosacea difficult to cope with

PAPER: Quality of life impact of ocular rosacea,

http://rosacea.ii.net/news/2007/03/ocular-rosacea-difficult-to-cope-with.html

4. aveeno ultra calming with feverfew: product reviews

REVIEWS: Aveeno has released 3 products from their `Active Naturals
Feverfew' range ; Ultra-Calming Daily Moisturizer with SPF 15,
Ultra-Calming Moisturizing Cream and Ultra-Calming Foaming Cleanser.

http://rosacea.ii.net/news/2007/03/aveeno-ultra-calming-with-feverfew.html

5. lavender, arnica, aloe vera, tea tree oil, and calendula ; do they work ?

MAGAZINE: Natural first aid: Are natural first-aid remedies effective?'

http://rosacea.ii.net/news/2007/03/lavender-arnica-aloe-vera-tea-tree-oil.html

6. pathogen infection (Chlamydia pneumoniae) cause theory

COMMENTS: A really interesting thread is going on in the
rosacea-support group. Dan is airing some of his thoughts on how a
pathogen might lead to the chronic inflammation we see in rosacea.

http://rosacea.ii.net/news/2007/03/pathogen-infection-chlamydia-pneumoniae.html

7. so just how does metrogel work ?

COMMENTS: Actually the way that metronidazole works is well known. How
the effect of metrogel leads to a benefit in rosacea, well, that is
something worth exploring some more later on.

http://rosacea.ii.net/news/2007/03/so-just-how-does-metrogel-work.html

8. exotic and expensive cosmetics, do they work ?
WEB SITE: Golf for Women: First Annual Skin Care Awards.

http://rosacea.ii.net/news/2007/03/exotic-and-expensive-cosmetics-do-they.html

9. ocular demodex, tea tree oil as a treatment

PAPER: Corneal Manifestations of Ocular Demodex Infestation
PAPER: Clinical treatment of ocular demodecosis by lid scrub with tea
tree oil
PAPER: In vitro and in vivo killing of ocular Demodex by tea tree oil.

http://rosacea.ii.net/news/2007/03/ocular-demodex-tea-tree-oil-as.html

pathogen infection (Chlamydia pneumoniae) cause theory

2007-03-28T22:30:00.001-07:00

A really interesting thread is going on in the rosacea-support group. Dan is airing some of his thoughts on how a pathogen might lead to the chronic inflammation we see in rosacea. Even though Dan clearly states he has no medical background (and indeed it is worth remembering this point) it is clear that he has done a lot of reading on this topic.

Message 93555: Rosacea and pathogen link? (be sure to read the followup posts at the bottom of the thread too).

Some more thoughts on a possible link: Chlamydia pneumoniae and Rosacea: A potential link?

Chlamydia pneumoniae may be something new to many (it was to me), so also see the wikipedia page: Chlamydophila pneumoniae

lavender, arnica, aloe vera, tea tree oil, and calendula ; do they work ?

2007-03-28T22:29:00.001-07:00

Australia's Choice magazine is an independent magazine that reviews products from the point of view of the consumer. Recently they published an articled titled `Natural first aid: Are natural first-aid remedies effective?'

The summary of the article ;

There’s plenty of anecdotal evidence from years of traditional use, but scientific evidence for the clinical effectiveness of natural first-aid remedies is generally lacking.

Most of the world relies mainly on natural medicines, and their popularity is growing in the west. You can easily find natural first-aid remedies in pharmacies and healthfood shops. But can you be sure that they’ll work?

Something I hadn't heard of before is a body called `Commision E'. Where available the article cites findings from Commission E.

Commission E

An exception to the lack of scientific study of natural remedies is Commission E, a German government regulatory agency composed of scientists, pharmacists, toxicologists, physicians and herbalists that has produced a series of documents known as herbal monographs — essentially formal reviews of medicinal herbs based on the available scientific evidence as well as evidence from traditional use, case studies and the experience of modern herbalists. The monographs are considered to provide authoritative information including approved uses of the herbs and their side effects, interactions and doses.

See the full article for examples of where Commission E has published relevant information.

Some of the remedies in this article have been discussed in the past as possible treatments for rosacea. Unfortunately there isn't much in this well written article suggesting that any of these natural remedies have been proven as effective for inflammatory skin diseases.

Following are some interesting extracts ;

Aloe Vera

The evidence is mixed, but it probably can’t hurt to try certified aloe vera gel (or aloe vera juice squeezed directly from the plant, if you have one) on minor wounds and burns/sunburn — and it might work.

Arnica

Arnica montana is a medicinal herb with a long history of use for treating swelling and bruising resulting from blows, and injuries such as sprains. Arnica flower is commonly available in both herbal and homeopathic preparations.

Clinical evidence for arnica as an effective first aid treatment is lacking, but people with osteoarthritis might want to give it a go.

Calendula

Calendula officinalis, or marigold, is a member of the daisy family (Compositae/Asteraceae). Its preparations have been used since ancient times to treat inflammatory skin conditions and accelerate wound healing.

Lavender oil

Oil from the lavender flower (Lavandula angustifolia) has been used as an antiseptic in medicine since ancient Arabian, Greek and Roman times.

The clinical evidence for its effectiveness as an antiseptic is lacking, though sprinkling lavender oil in your bathwater to help you relax is likely to be safe enough.

Tea tree oil

Australian Aborigines have used the leaves of the Melaleuca alternifolia plant for medicinal purposes for many centuries. Tea tree oil’s traditional use is as an antiseptic for preventing and treating minor skin infections.

The evidence so far is encouraging, though not definitive. It may be worth a try on insect bites and minor skin infections.

Further Reading ;

so just how does metrogel work ?

2007-03-28T22:27:00.001-07:00

I have mentioned a few times in the past that the way that metrogel helps rosacea is unknown. This statement deserves some clarification. Actually the way that metronidazole works is well known. How the effect of metrogel leads to a benefit in rosacea, well, that is something worth exploring some more later on.

You may wonder why there is so much emphasis on the metronidazole based products ? As much as metrogel and its friends metrocream, metrolotion, rozex, noritate (and indeed generic metrogel, also from fougera) are not a panacea for rosacea, they do represent the single most proven treatment specifically for rosacea. Thus newly diagnosed rosacea sufferers are quite likely to leave their doctor's surgery with a script for metro-something. All the studies show that in many cases metrogel does indeed work. Further, other studies clearly show that combining metrogel with antibiotics results in better clearance.

So back to `how does it work ?' Well my one sentence summary is "metronidazole breaks down into a substance that kills the DNA of the cells of some particular bacteria and protozoa".

Thanks to Dan for sending me the following links ;

From DrugBank: Metronidazole

Pharmacology: Metronidazole, a synthetic antibacterial and antiprotozoal agent of the nitroimidazole class, is used against protozoa such as Trichomonas vaginalis, amebiasis, and giardiasis. Metronidazole is extremely effective against anaerobic bacterial infections and is also used to treat Crohn's disease, antibiotic-associated diarrhea, and rosacea.

Mechanism of Action: Unionized metronidazole is selective for anaerobic bacteria due to their ability to intracellularly reduce metronidazole to its active form. This reduced metronidazole then disrupts DNA's helical structure, inhibiting bacterial nucleic acid synthesis and resulting in bacterial cell death.

From Antibiotics that Inhibit Nucleic Acid Synthesis

Figure 11-8. Structure of metronidazole and its mechanism of action. Metronidazole enters an aerobic bacterium where, via the electron transport protein ferrodoxin, it is reduced. The drug then binds to DNA, and DNA breakage occurs.

(An anaerobic organism is any organism that does not require oxygen for growth. Protozoa are a particular type of single cell organisms.)

This naturally leads to the followup question - if eliminating the substances that metronidazole (and for the purposes of this argument, lets include systemic antibiotics as well) is active against leads to relief from some rosacea symptoms, what does that say about the possible cause of rosacea ? Now, that is a question that there isn't much agreement about and something worth talking about some more, later.

Further Reading ;

ocular demodex, tea tree oil as a treatment

2007-03-28T22:22:00.001-07:00

Other recently published studies are showing that tea tree oil kills demodex. See ;

Clinical treatment of ocular demodecosis by lid scrub with tea tree oil., Cornea. 2007 Feb;26(2):136-43. Conclusions: Demodex is resistant to a wide range of antiseptic solutions. Weekly lid scrub with 50% TTO and daily lid scrub with tea tree shampoo is effective in eradicating ocular Demodex.
In vitro and in vivo killing of ocular Demodex by tea tree oil. [full text], Br J Ophthalmol. 2005 Nov;89(11):1468-73 Conclusions: Demodex is resistant to a wide range of antiseptic solutions. Weekly lid scrub with 50% TTO and daily lid scrub with tea tree shampoo is effective in eradicating ocular Demodex.

I have always pushed the line that demodex mites have thus far only been proven to be innocent bystanders in rosacea symptoms. In order to prove that the mites are responsible for some ocular symptoms we now need double blind studies to show 2 things - firstly that killing demodex does lead to a reduction in ocular rosacea symptoms and secondly some studies that show how tea tree oil works. We also now need larger studies that confirm that tea tree oil is a safe therapy for ocular symptoms.

Corneal Manifestations of Ocular Demodex Infestation, Kheirkhah A, Casas V, Li W, Raju VK, Tseng SC., Ocular Surface Center, Miami, Florida. Am J Ophthalmol. 2007 Mar 19

PURPOSE: To report the corneal manifestations in eyes with Demodex infestation of the eyelids.

DESIGN: Noncomparative, interventional case series.

METHODS: This retrospective review included six patients with Demodex blepharitis who also exhibited corneal abnormalities, which led to suspicion of limbal stem cell deficiency in three cases. All patients received weekly lid scrubs with 50% tea tree oil and a daily lid scrubs with tea tree shampoo for a minimum of six weeks. Improvement of symptoms and corneal and conjunctival signs were evaluated.

RESULTS: All six patients exhibited ocular irritation and conjunctival inflammation, while meibomian gland dysfunction (n = 5), rosacea (n = 4), and decreased vision (n = 3) also were noted despite prior treatments with oral tetracycline, topical steroids with antibiotics, and lid scrub with baby shampoo. These patients were proven to have Demodex folliculorum (n = 6) and Demodex brevis (n = 3) by microscopic examination of epilated lashes. Their corneal manifestation included superficial corneal vascularization (six eyes of five cases), marginal corneal infiltration (two eyes of two cases), phlyctenule-like lesion (one eye of one case), superficial corneal opacity (two eyes of two cases), and nodular corneal scar (two eyes of two cases). After treatment, the Demodex count was reduced from 6.8 +/- 2.8 to 1 +/- 0.9 (standard deviation; P = .001). All patients showed dramatic resolution of ocular irritation, conjunctival inflammation, and all inflammatory, but not scarred, corneal signs; three patients showed improved vision.

CONCLUSIONS: A variety of corneal pathologic features together with conjunctival inflammation, commonly noted in rosacea, can be found in patients with Demodex infestation of the eyelids. When conventional treatments for rosacea fail, one may consider lid scrub with tea tree oil to eradicate mites as a new treatment.

Rosacea News February 2007

2007-03-02T04:07:00.000-08:00

Rosacea News February 2007

1. demodex bacteria - could that be the cause ?

PAPER: Electron microscopic investigation into the possible etiology of

rosacea and the implication for treatment,

http://rosacea.ii.net/news/2007/02/demodex-bacteria-could-that-be-cause.html

2. red face and photodynamic therapy (PDT)

PAPER: Topical photodynamic therapy for treatment of facial erythema

with acne vulgaris

http://rosacea.ii.net/news/2007/02/red-face-and-photodynamic-therapy-pdt.html

3. topical antihistamine reduces oily skin and acne

PAPER: A 4-week, randomized, double-blind, parallel group trial

evaluating the efficacy and tolerability of sebum control product in

male and female subjects with oily skin appearance and mild to moderate

acne vulgaris

http://rosacea.ii.net/news/2007/02/topical-antihistamine-reduces-oily-skin.html

4. revlon (Almay) sensitive skin cream helps rosacea

PAPER: Use of a liquid cream improves sensitive rosacea-prone skin

http://rosacea.ii.net/news/2007/02/revlon-almay-sensitive-skin-cream-helps.html

5. Mariah Carey has rosacea ? celebrities as advocates ?

MAGAZINE: I’ve got thighs and buttocks, I'm never going to be a size zero

http://rosacea.ii.net/news/2007/02/mariah-carey-has-rosacea-celebrities-as.html

6. rambazole dose and side effects being studied

PAPER: Tolerability, safety, and pharmacokinetics of single and

multiple oral dosages of R115866 in healthy volunteers

http://rosacea.ii.net/news/2007/02/rambazole-dose-and-side-effects-being.html

7. cleansing your SD skin with a sonic brush (Clarisonic)

PAPER: An efficacy assessment of a novel skin cleansing device in

seborrheic dermatitis,

http://rosacea.ii.net/news/2007/02/cleansing-your-sd-skin-with-sonic-brush.html
_______________

[rosacea] RE: No evidence that rosacea is primarily a vascular disorder

2006-12-13T16:32:00.000-08:00

Thanks for the link Brady, Very interesting.

They say that there is no direct evidence that rosacea is primarily a vascular disorder. I've seen it in a few places referred to as 'Weak, Leaky capillaries'. Dan pointed out previously that Telangiectasia refers directly to permanently dilated vessels, not broken or leaky vessels, so the following quote from the article seems to make sense.

Quote

"The basic abnormality seems to be a microcirculatory disturbance of the function of the facial angular veins"

I guess if they have located a recurrent abnormality, then resolving this issue could prove beneficial.

I take an anit-histamine every day, and part of my diet restrictions include avoiding foods that are high in histamine, or would cause the body to release histamine. I am not sure if I read this correctly, but a quoted line of text says

Quote

"The response of the facial vessels to adrenaline, histamine and acetylcholine is normal, and the vessels do not seem abnormally fragile, so the main abnormality is probably in the dermis surrounding blood vessels rather than in vessel walls."

Which to my understanding suggested histamine was not an agonist to facial flushing.

And they then say this

Quote

"Among the mediators proposed to be involved in the erythematous response are substance P, histamine, serotonin, and prostaglandins but the trigger remains unknown."

Does this mean that although histamine is not directly related to facial flushing, that it is related to swelling/inflammation (erythematous response) of the surrounding skin?

And I see there is a new subtype, "Gram Negative Rosacea'. Is this any of your doing Dan?

Another couple of paragraphs that caught my attention were the reference to Demodex Folliculorum.

Quote

"As stated above, we do not think that Demodex folliculorum mites have a causal role in rosacea. However, massive infestations may aggravate the condition. A check for mites is best done with the skin-surface biopsy technique (place a drop of cyanoacrylate on a glass slide, cover with immersion oil, and examine with the 10 x or 20 x objective in the light microscope)"

"The mites are satisfactorily controlled with lindane (y-hexachlorocyclohexane), crotamiton, or benzyl benzoate once daily for two to five days."

The statement shows a satisfactory control of mites with the application of lindane, crotamiton or benzyl benzoate (toxic insecticides I am assuming) in five days. If a Rosacea patient has been checked and confirmed to be mite infested, this seems like a MUCH better treatment option (Of course recommended by a Derm or Doctor and applied with supervision) than the long and hard process Tamara has been going through.

Matt.

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Re: [rosacea] Success?

2006-12-13T15:27:00.000-08:00

Did you have IPL or IPL with RadioFrequency (RF)? Do you know the difference
between the two? I just had a FotoFacial RF and its been about a week and,
although red and swollen at first, I am starting to see a bit of
improvement. Thanks for the help and I hope every thing goes well. Happy
Holidays.
J

>From: Liz Crawford <projectliz@yahoo.com>
>Reply-To: rosacea-support@yahoogroups.com
>To: rosacea-support@yahoogroups.com
>Subject: Re: [rosacea] Success?
>Date: Sat, 9 Dec 2006 20:36:30 -0800 (PST)
>
>I had a lot of success with IPL treatments (3 in
>total). Last summer my rosacea was totally out of
>control (full facial flushing, ocular symptoms, and
>swelling on my cheeks and chin), despite the fact that
>I was taking an oral antibiotic (minocycline) and
>using a topical treatment. The IPL worked so well
>that even my dermatologist was shocked by my
>improvement. I have minimal flushing across my cheeks
>and nose in response to heat but that's about it. And
>I'm no longer taking an oral antibiotic or using any
>topical treatments (although I do still use restasis
>eye drops).
>
>That said, I should note that following each laser
>treatment my symptoms would always get worse before
>getting better. Right afterwards I was okay. Then
>about a week or so later I would start to flush, etc.,
>which would gradually taper off over the next few
>weeks.
>
>Regarding my experience more generally, the big issue,
>in addition to cost (I spent $1,200 overall), was
>finding a competent laser practitioner. That's one
>thing I got from reading the posts on this site- how
>important it is to go to someone who's good. I went
>to Vein Solutions in Indianapolis, IN (Dr.
>Finkelmeier).
>
>So for me, the IPL was definitely worth it (I think I
>was especially lucky in that I tolerated the laser
>really well - no burning, etc.). I was so depressed
>this past summer every time I looked in the mirror at
>my red and swollen face. I'm not 100% cured (still a
>bit of redness and enlarged pores), but it is so much
>better- really looks pretty normal.
>
>I hope this isn't too much detail. I just know that
>it was very helpful for me to read about other
>people's experiences with IPL (and other treatments)as
>well as their comments on various doctors.
>
>Best of luck.
>
>Liz
>
>--- hothead907 <jordanhuss@msn.com> wrote:
>
> > Has anyone actually had any success in beating their
> > rosacea without a
> > myriad of pills, vitamins, or topical solutions?
> > What about laser
> > treatments or IPLs or other forms of therapy? I
> > highly doubt anybody
> > who has had success even visits this group anymore,
> > but for those
> > people who have beat it and still visit the forum,
> > please let us know
> > what worked for you. Thanks.
> >
> >
>
>
>
>
>__________________________________________________________
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>Everyone is raving about the all-new Yahoo! Mail beta.
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[rosacea] Prednison, thin skin

2006-12-13T12:39:00.000-08:00

Hello,
A few days ago I questioned the statement by some over whether
prednisone (systemic corticosteroid) use was well documented and
established to cause steroid induced rosacea.
I was surprised to hear this and so did a quick literature search
using the appropriate drug resources ( I did not check the package
insert to prednisone as some of the infomation from the following
sources comes from the inserts and also the inserts aren't always
updated, anyway):
1)LexiComp DIH, 2006: Skin atrophy <1% (This is a new update, as this
was not mentioned in the 2005 verson of the DIH).
2)American Hospital Forulary Service (AHFS 2005): Thin skin
3)Micromedex, 2006: Skin atrophy
4)Manual of Dermatologic Therapeutics, 2002: No mention (This is
really dated...I think a more recent version is already available). I
incl. this reference bc it is a respected therapy-based (as opposed
to physiology-based)quick reference.
5)Facts and Comparisons, 2006: No mention
6)Rxlist.com (updated 2006)Regarded by most PharmD's as the most
complete online drug monograph tool, available to anyone. I highly
recommend it: Facial erythema.
NOTE: Under "Indications and dosage" check out the new dosing method
for long-term users, "Alternate Day therapy".
So, I would say that since 4 of 5 VALID sources list skin thinning,
atrophy, or erythema, that I was wrong in saying that SIR was not
well supported in the literature.
I still feel a good delving into the primary literature to find the
details of SIR and predisone may yield revealing data (et at what
doses does this most commonly occur?)
This is a good question for Artist...what dosing regimen are the
patients with facial redness ususally on?
If I find any more info...I'll post.
Thanks for the heads-up ya'll.
Perry
Perry

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Re: [rosacea] Salt intake

2006-12-13T11:38:00.000-08:00

Donna
Im glad! heck I laugh at it too. when the water goes there, I just make sure I get it out of my system FAST! I look and say, wow the water is gone, its nice to feel flat chested again!
haha hope your morning gets better! oh by the way, im flat today YIPEEEEEEE
Ricky (no salt for me today)

Donna Collins <donna9142002@yahoo.com> wrote:
Ricky,

Thanks for making me laugh heartily this morning...it has been a rough one .

Donna

Ricky Butler wrote:
I always eat saltless eggs! I do notice salt for me, makes me flush/break out a bit
I love pringles potato chips..but the salt gets me! salt does this more than sugar, for me.
I am thin built, usually 160 - 162 lbs at 5"9" but salt makes me retain more water than the hoover dam!! it goes to my chest , the excess water, I feel like Dolly Partons brother! haha

nurse_artist wrote:
Anyone notice improvement when eating less salt? My thinking is that
lower salt intake leads to less edema (swelling), which might help
rosacea symptoms because less fluid would be retained to leak out of
the capillaries.

I started thinking about this and ate my eggs without
salt at breakfast today. Not as good.. he he he!

Cheers!

Artist

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Re: [rosacea] cleaning the house/ what do you use??

2006-12-13T10:15:00.000-08:00

wow a maid! well arthritis and rosacea can certainly take a toll. I absolutely love cleaning now, no longer a chore because of what I use now. tamara

kemx@sbcglobal.net wrote: with all my other tendon and arthritis problems + rosacea i have a maid come in once a month for thourough cleaning.
other wise i use those clorox wipes in citrus, and a green clorox softscrub bleach gel.
also i use 7th generation fragrance free dish washing liquid for hand wash, and also for washing our hands here at home [i put it in pump bottles].
----- Original Message -----
From: tamara
To: rosacea-support@yahoogroups.com
Sent: Tuesday, December 12, 2006 8:34 PM
Subject: [rosacea] cleaning the house/ what do you use??

Hey guys, I just wanted to mention that I know I use to always flare
up around certain cleaning products to clean my house, and hated the
smell too, (very strong).
Well for about at least over a year now, and I am sure it has helped
me because ever since I made the change from buying over the counter
cleaning supplies, I now use my own (i make it myself and love it, no
longer having irritated skin and runny nose). for glass, I use vinegar
and water,(half and half) instead of what i use to use (windex).
For cleaning counters and bathroom and so on, I make a solution with
water, real lemon, few drops of tea tree oil, baking soda, and
vinegar.... it does a great cleaning and smells fresh. I read this in
a magazine and will never change back, and ive saved alot of money as
well. Just thought it was worth mentioning, especially our sensitive
skin, besides who needs all these added chemicals anyway? and look
what they used back in the olden days, certainly not all this junk.
This is my opinion, I am a strong beleiver in taking care of our
environment and have you seen the latest on oprah and global warming?
very interesting. Good night guys, tamara

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Re: [rosacea] my update on the z cream

2006-12-13T09:59:00.000-08:00

Brian, if you can find a doctor to check your skin, and if these mites show up in abundance, then just imagine you can start this z cream and at least you will know for sure whats going on. Worth it for sure!! tamara

Brian Shaffner <brianshaffner@earthlink.net> wrote: Yes, it does, thanks. Those are amazing results! May be time for a test
patch soon... :)
----- Original Message -----
From: rose jill
To: rosacea-support@yahoogroups.com
Sent: Tuesday, December 12, 2006 7:46 PM
Subject: Re: [rosacea] my update on the z cream

Brian thanks. The z cream is helping with the flushing meaning when I eat
or drink something I react less and dont get red as easily as i did. My skin
is still dry and still healing but the layers of my skin is soft and looking
more normal and pinky instead of red. As for the little veins, i have some
very small though, I am not sure if they are smaller, to me they seem less
visible but I am not 100% sure on that. Lately I had 2 glasses of wine to
see what would happen, I use to flush like redd, this time I had a mild
flush. not as long and red either, hope this helps you. tamara

Brian Shaffner
wrote: Tamara,

Congrats on your perserverence and success!

I am very curious about something. My own rosacea consists mainly of
persistant pinkness in the rosacea areas, flushing when triggered, a
little
telegenta (um, I know I just slaughtered the spelling... the veins!) and
dermatitas, the latter which has pretty much been handled now. For
whatever reason I really have not had much in the way of P&P. Has the Z
addressed any of the kinds of symptoms I mentioned? I know it works really
well on the P&P for quite a few people. What about the other symptoms? I
asked this question months back on the Z cream board, but no one answered.
When you say 'rosacea flares' do you mean outbreak of papules, flushing,
or
both?

----- Original Message -----
From: tamara
To: rosacea-support@yahoogroups.com
Sent: Monday, December 11, 2006 8:28 PM
Subject: [rosacea] my update on the z cream

Hey everyone, Its been now about 3 months and 2 1/2 weeks since I
have started using the z cream. The last post I had indicated I was
50% better. I am here to say my skin is even better now since then,
which I am really ecstatic about, since I have been suffering with
this rosacea for around or close to 10 years give or take. Again, I
am type 2 (meaning papular rosacea). To be quite frank, over the
many years of having rosacea, it was always controllable for me
until the past 2 years where it became worse, and I had more
triggers that I could not comprehend. I have always wanted to stay
clear of antibiotics, and I am a firm believer in a more natural way
to go, although when I was younger I did use metrocream which I had
to get off of very quickly due to a metallic taste on my tonque. I
have never used any form of laser, and Ive always used natural
remedies to treat it. Anyway, the past few years, I became fed up
and just plain sick and tired of worrying about the very thing I
never use to be bothered about, especially due to the fact I use to
travel alot, and was in the sun alot, enjoyed having a drink, and
never had problems. Anyway, to make a long story short, I am pleased
to say this Z cream has been a life saver for me and my rosacea
flares are occurring less than they use to. I even ate and drink
things I always had problems with, and nothing so far. My skin is
looking better, and I am just grateful of this, I am planning on
using nightly until 150 days and then maintenance to keep them away!
I want you all to know that if you have not tried this, BELIEVE!!
dont give up, and I just hope it gets better and better and gone, no
more worrying. Love you all, I will keep you all posted. Tamara

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Re: [rosacea] z cream

2006-12-13T09:55:00.000-08:00

Melissa, if you tested negative for the mites, then you would not use the z cream to treat it. You would need to test positive, an overabundance of mites, then use the z cream, and yes it is also called z ointment. hope this helps. Did you have your skin checked under a microscope with your doctor? tamara

melissawohlbattista <melissawohlbattista@yahoo.com> wrote: Hi guys,
This question is mainly for Tamara (or anyone else who knows the answer)
Do you know if the Z cream works on rosacea even if you tested negative
for the demodex mites?? Also, I checked out the websit and could only
find the z ointment. Is that the same thing as the z cream??
Any info is much appreciated. Thanks.
Melissa

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