Tuesday, January 01, 2008

Rosacea News December 2007

1. Senetek Trialling Pyratine 6 / PRK124

December 30th, 2007, by Digital Davo | clinical trials, papules & pustules

A new trial has just been posted that will be looking at how Pyratine 6 (a variant of Kinetin) treats the papules & pustules, redness and visible blood vessels of rosacea. From Clinical Trial NCT00580723: Effects of PRK 124 Lotion in Acne Rosacea The purpose of this open-label study is to determine the tolerance and efficacy of twice-daily application …

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2. Nerve Growth Factor inhibitor - acerola seed extract

December 27th, 2007, by Digital Davo | patents, seborrheic dermatitis

Trawling patent applications is challenging but also interesting. There is a huge mine of information available for us to scavenge information that might lead to future treatments. I thought this patent was interesting because it deals with something that I hadn’t heard of before, but seems like it might have some potential. This patent application makes me wonder if we will see anything else …

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3. acne lotion good for cleaning pen from toys

December 21st, 2007, by Digital Davo | acne treatments, in the news

OK a semi-serious post for this time of year. An interesting blog posting over at Baby Toolkit suggests that 10% benzyl peroxide cream and sunlight is perfect for removing pen marks from a plastic doll. From Clear Unsightly Blemishes: the Case of the Ballpoint Baby Doll Here is before ;   and here is after …

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4. Patents abound for treating rosacea with alpha agonists

December 19th, 2007, by Ben | patents

Their has been much talk lately about using alpha adrenoceptor agonists as rosacea treatments because they show vasoconstrictor actions. Some examples are brimonidine, oxymetazoline, naphazoline, and others.

There are quite a few patents out there discussing these, and even testing some of them. Some of these patents have been mentioned before on the site.

Here are links to some of these patents.

US20040242588
Compounds, …

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5. kinetin & niacinamide for anti-aging

December 14th, 2007, by Digital Davo | moisturizers, topicals 

This study shows that kinetin and niacinamide work together well to provide anti-aging effects for asian skin. Previous studies that have been highlighted by Rosacea News have also shown that topical kinetin is a good anti-aging moisturizer for rosacea sufferers and may even show some benefit for rosacea symptoms. The clinical anti-aging effects of topical kinetin …

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6. get ready for ocular oracea

December 12th, 2007, by Digital Davo | doxycycline, ocular rosacea, oracea

Thanks for the tip from Ben. A clinical trial listed for treating both facial and ocular rosacea with Oracea suggests that Oracea might soon be marketed directly as an ocular rosacea treatment. This phase 2 trial’s purpose is to determine the safety and efficacy of sub-antimicrobial dose doxycycline in the treatment of patients who have both blepharitis and facial rosacea. The trial …

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7. FDA approves Lyrica for Fibromyalgia

December 10th, 2007, by Digital Davo | in the news

Whilst this was announced back in June this year, I thought it was worthwhile highlighting it here in case it is of interest to rosacea sufferers who also suffer from chronic pain. From the FDA Consumer Update: Living with Fibromyalgia, First Drug Approved People with fibromyalgia have typically turned to pain medicines, antidepressants, muscle relaxants, and sleep medicines. On …

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8. how Collagenex are Promoting Oracea

December 6th, 2007, by Digital Davo | oracea, tetracyclines

A recent investor presentation from Collagenex shows some interesting insights into how Collagenex are promoting Oracea. Oracea is promoted as safe and effective for long term use. It was reported that the average duration of Oracea therapy is 4 months, compared to an average of 2.5 months for other rosacea prescriptions. 52% of Oracea prescriptions are refills - the presentation suggests that …

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9. treating ocular rosacea with amniotic membrane transplant

December 4th, 2007, by Digital Davo | ocular rosacea

This case report of one patient shows a remarkable treatment possibility for severe ocular rosacea. The patient also suffered from papulopustular rosacea and rhinophyma and did not respond to full dose doxycycline. Three attempts to glue his perforated cornea failed. The paper suggests that corneal perforation is quite rare in ocular rosacea.

The amniotic membrane transplant was a success, both sealing the perforation, and restoring good …

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10. genetic links for psoriasis, lupus

December 3rd, 2007, by Digital Davo | research

A quick news bite about some new links found for a genetic root for psoriasis and lupus. I like that the reporter doesn’t try to dress up this announcement as anything other than a small advance in our knowledge of these 2 diseases. The research into a provable genetic link for rosacea symptoms is still at a very early stage. Maybe one day …

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most popular blog posts in 2007

Looking through my web site statistics I can see that the following Rosacea News items received the most visits during the year.

I'm looking forward to 2008 to see what makes the Rosacea News.

1. eucerin redness relief product reviews

In 2005 a new range of skin care products from Eucerin (Beiersdorf Inc) called Eucerin Redness Relief was released. They are claimed as “Safe for sensitive skin and appropriate for Rosacea”.

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2. how to cure a red face

Many rosacea sufferers are looking for help to reduce the redness of their face. This is one of the first rosacea symptoms that people might notice. What treatments have fellow rosacea sufferers used to hide the ruddiness and angry face that sometimes accompanies rosacea ? I’ll go through what I see as your current best options.

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3. choosing a moisturizer

An excellent consumer report about how to choose a moisturizer. The article gives some background on how moisturizers are formulated, how they work, and the operation of common active ingredients. A table at the end of this document compares about 75 available moisturizers, classifying them under Face, Hands and Feet. Highly valuable for anyone searching for a moisturizer as part of their daily routine.

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4. treating rosacea with herbs

There is a lot of interest from rosacea sufferers in treating their rosacea with natural or herbal therapies and remedies. Many are keen to avoid treatments like antibiotics and metrogel. This paper is by far the best collection of information about natural products I’ve found.

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5. red face: when flushing isn't rosacea

This paper explores the different problems that may be causing flushing. The list of possible reasons other than rosacea is extensive. The author was kind enough provide a full copy of this paper, so contact me if you’d like to read it.

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6. focus on finacea

Finacea is a topical rosacea treatment made by Intendis. Its main active ingredient is azelaic acid 15%. Officially, finacea “is a topical treatment for the inflammatory bumps and lesions of mild to moderate rosacea”.

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7. periostat goes generic, get ready for oracea:

Periostat (20 mgs doxycycline hyclate) has been helpful to some rosacea sufferers. Originally developed to combat periodontal disease (gum disease), periostat was approved by the FDA in 1998. Recently the FDA approved the introduction of generic periostat equivalents.

Oracea contains doxycycline, the same active ingredient as CollaGenex’s gum disease treatment Periostat. CollaGenex is shifting its focus to the dermatology market following the approval of generic competition for Periostat.

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8. ocular demodex - tea tree oil as a treatment:

This recently published paper suggests that a variety of ocular symptoms might be caused by demodex infestation. Six patients all having demodex present, and suffering with recalcitrant symptoms (including 4 diagnosed with rosacea) were given tea tree oil for a weekly eyelid scrub and tea tree shampoo for a daily scrub.

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9. focus on metronidazole

Metronidazole is a prescription drug that is available in several formulations. As an oral treatment it is known as flagyl. Topical metronidazole is available as noritate, metrogel, rozex, metrogel 1%, metrolotion and metrocream.

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10. focus on low dose accutane:

The mechanism by which low dose accutane (isotretinoin) i.e. around 10mg a day, is effective in treating rosacea is not clearly understood. Just the name accutane is enough to strike fear into many doctors and patients.

Hopefully the following articles will provide some pointers to useful information when researching whether accutane/roaccutane is a suitable treatment for your rosacea.

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